Brochure.pdfPharmacology & Toxicology Courses
PHM 340 - Principles of Drug Action
Chemistry and/or Physiology background recommended. Not open to students with credit in: PHM 350
Factors influencing drug action. Absorption, distribution, and elimination of drugs. Factors controlling intensity, selectivity of drug action, and nature of drug action. Mismatches of drug presence and drug action including receptor effector coupling mechanisms and mechanisms of tolerance to drug action. Offered first half of semester.
PHM 350, Section 730 - This section is offered Summer Semester as online course. (1 credit).
PHM 350 - Introduction to Human Pharmacology
Section 001 - General principles of pharmacology: Pharmacokinetics and pharmacodynamics. Pharmacology of central and peripheral nervous systems. Drugs affecting cardiovascular and renal systems to treat cardiac dysfunction and hypertension. Cancer chemotherapy. Anti-infective drugs. Drugs targeting endocrine systems. Some biology and/or chemistry is strongly suggested; PSL250 or PSL310, or PSL431 and PSL432 are prerequisite courses for MSU students. Dr. Cobbett's faculty page
On-campus live lecture Fall and Spring Semester (3 credits). Section 001 Schedule
Online Summer only. (3 credits). Online Schedule
PHM 431 -- Pharmacology of Drug Addiction
Provide students with an introduction to pharmacology in the context of understanding the mechanisms of action of drugs of abuse. Major topics include: Pharmacodynamics, Pharmacokinetics, Introductory neuroanatom, Introductory neurophysiology, Alcohol use and abuse, Opiate use and abuse, Cocaine and amphetamine abuse, Barbiturate use and abuse, Benzodiazepine use and abuse, Hallucinogen abuse. Recommended background: Zoology or Human Biology or Psychology or Biochemistry or Physiology. Dr. Galligan's faculty page
Face-to-face on-campus classroom Fall (3 credits)
Online Summer (3 credits) 431 Flyer.pdf
PHM 450- Introduction to Toxicology
Mammalian toxicology. Disposition of chemicals in the body, detoxification, elimination, and mechanisms of toxicity in major organ systems. Selected toxic agents; carcinogenicity, reproductive toxicology, pesticides, lead, mercury, and others, other selected toxic agents. Prerequisites include biology and chemistry such as (BS 110 or LBS 144) and (BS 111 or LBS 145 or BS 111) and CEM 251.
Fully online summer (3 credits) Sections 730+ flyer.pdf
Face-to-face on-campus classroom spring (3 credits)
PHM 480 - Special Problems
Individualized research on special topics supervised by Department faculty. This can be an assigned laboratory research project or an independent study topic agreed upon by student and instructor. Check out one medical student's dioxin presentation derived from his research paper.
PHM 810 -- Synaptic Transmission
Chemical and electrical aspects of nerve impulse transmission at synaptic and neuroeffector junctions. Influence of drugs. Spring odd years. 3 (3-0)
PHM 813 -- Cardiovascular Pharmacology
Effects of drugs on normal and diseased physiological and biochemical process in vascular and cardiac cells.
Face-to-face on-campus classroom in Spring of even-number years 3 (3-0)
Online Summer every year 3 credits
PHM 816 -- Integrative Toxicology: Mechanisms, Pathology and Regulation
Biochemical, molecular, and physiological mechanisms of toxicology. Functional and pathological responses of major organ systems to chemical insult. Mechanisms of mutagenesis, carcinogenesis, and reproductive toxicology. Concepts in risk and safety assessment. Fall of odd-number years 3(3-0)
PHM 819 -- Principle of Drug-Tissue Interactions
General principles relevant to the interaction of chemicals with biological systems. Topics include pharmacokinetics and/or pharmacodynamics. Topics include: Pharmacodynamics, Pharmacokinetics, Receptors, Second messengers, Drug design, Drug tolerance and dependence, Chemical carcinogenesis, Chemical mutagenesis, Chemical teratogenesis, and Risk assessment. Undergraduate degree in biology, chemistry, or related field is recommended. Call 517.353.9619 for required department approval.
Hybrid/blended online in summer for PhD students and others with approval. Section 740 (2 credits for both 1st & 2nd semester topics), section 741 (1 credit only for first half of semester), section 742 (1 credit only for second half of semester) Flyer.pdf
Online in summer and fall for other students (2 credits).
PHM 820 - Cellular, Molecular and Integrated Systems Pharmacology and Toxicology
Comprehensive overview of the cellular and molecular mechanisms of drug and chemical actions on the major organ systems of humans and other mammals. Fall 4 (4-0) PHM 820 flyer.pdf
PHM 827 - Physiology and Pharmacology of Excitable Cells
Function of neurons and muscle at the cellular level: membrane biophysics and potentials, synaptic transmission, sensory nervous system function. Fall 4 (4-0)
PHM 829 - Neuropharmacology
Description of targets in the mammalian central nervous system of clinically useful drugs and the mechanism of action, clinical use, and side effects of those drugs. Aspects of normal cellular neurophysiology. Treatment of Pain: Opiate receptor agonists. Treatment of Pain: Targeting ion channels. Treatment of Pain: Targeting ion channels II. Anticonvulsants, hypnotics and anxiolytics: Targeting GABA receptors. Antidepressants: Targeting noradrenergic and serotoninergic systems. Antipsychotics & Parkinson’s Disease: Targeting dopaminergic systems. Stroke and dementia: Cholinergic and glutaminergic systems.
Online Fall semester. PHM 819 pre-requisite and some physiology background is very helpful. (2 credits).
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PHM 830 - Experimental Design & Data Analysis
Practical application of statistical principles to the design of experiments and analysis of experimental data in pharmacology, toxicology, and related biomedical sciences. Course objectives: to provide students with a practical knowledge of statistical principles applied to the design, analysis and display of experiments in integrative pharmacology and other biomedical research. Variables, measurements, distributions and descriptive statistics. Confidence intervals, statistical significance, hypothesis testing & design. Comparing two sample means. ANOVA and multiple comparisons. Sample size estimation. Missing data, outliers, transformations. Association measures. Correlation, regression, curve fitting, multiple regression & logistic regression. Correlation, regression, curve fitting. Survival analysis . Undergraduate degree in biology, chemistry, or related field is recommended. Dr. Jackson's faculty page
Online summer and fall. (3 credits) PHM830 flyer.pdf
Hybrid/blended online & on-campus in Fall only (3 credits)
PHM 831 - Endocrine Pharmacology
Physiology, pharmacology, and toxicology of the endocrine system. Endocrine diseases, pharmacological intervention, hormone therapy, endocrine disruptors, role of hormones in normal metabolism and metabolic disorders, and animal models of endocrine and metabolic disorders. Course objectives: increase student understanding of the functioning of the endocrine system and its pharmacology, how it can be applied to hormone therapy, drug development, diagnostics and disease prevention, the organization and functioning of the cells that secrete a particular hormone. Emphasis on increasing student understanding of how failure of secretion or hypersecretion can lead to disease states and how they can be corrected using hormones or other pharmacological agents and mode of action of these agents. Topics include: Historical perspective and review of basic concepts, Hypothalamic hormones, Anterior pituitary hormones, Posterior pituitary hormones, Steroids-adrenal and gonadal, Thyroid hormones, Prostaglandins, local hormones, adipose tissue, Metabolism: role of hormones, metabolic disorders and role of hormones, and Endocrine disrupters and animal models of endocrine/metabolic disease. Dr. MohanKumar's faculty page
Online fall semester . PHM 819 pre-requisite. (2 credits)
PHM 833 -- Gastrointestinal & Liver Pharmacology
Specific drugs and their mechanisms of action in the treatment of gastrointestinal and liver diseases. Toxic effects of drugs and other xenobiotics on the gastrointestinal tract, including the liver. Course objectives: familiarize students with the uses and mechanisms of action of drugs used to treat gastrointestinal diseases and disorders, with gastrointestinal and liver toxins and their mechanisms of action. Topics include: Drug therapy of gastrointestinal secretory and motor disorders. Drug therapy of gastrointestinal and liver inflammatory diseases. Drug and other xenobiotic gastrointestinal and hepatic toxicology. Dr. Galligan's faculty page
Online in spring semester. PHM 819 pre-requisite. (2 credits)
PHM 834 - Respiratory Pharmacology
Integrative study of drugs, their mechanism of action, and their side effects in the treatment of major diseases and pathologies of the respiratory system. Provide students with an overview of the pharmacology of the respiratory system with emphasis on drug classes used to treat major diseases and pathologies that impact this system. Topics will include: Review of respiratory physiology as related to its pharmacology. Assessment of pulmonary function in animal models. Pathophysiology, drug classes and animal models in asthma. Pathophysiology, drug classes and animal models in emphysema. Pathophysiology, drug classes and animal models in chronic bronchitis. Pathophysiology, drug classes and animal models in fibrosis. Pathophysiology, drug classes and animal models in pulmonary hypertension. PHM 819 pre-requisite. (2 credits)
PHM 839 - Systems Neuroscience
Anatomy, pharmacology, and physiology of multicellular neural systems. Sensory, motor, autonomic, and chemo-regulatory systems in vertebrate brains. Spring 4(4-0). Interdepartmental With: Neuroscience, Human Anatomy, Physiology, Psychology, Zoology.
PHM 840 - Safety Pharmacology
Safety Pharmacology can be defined as the interface of pharmacology and toxicology in the discovery and design of new drugs. Pharmaceutical companies and regulatory agencies use a variety of preclinical studies to investigate the potential undesirable effects of a substance on body functions. Dr. Maddox's faculty page
Online in Spring (2 credits). PHM840 flyer.pdf
PHM 851 - Intellectual Property & Patent Law for Researchers
Fundamentals of intellectual property and patent law encountered by biomedical scientists, including issues of prevention, patent prosecution, and enforcement of patents in a litigation setting. Course objectives: to introduce students to the US patent system, trade secret and patented inventions, contractual protections in biomedical sciences, principles of obviousness, the purpose and elements of subject matter requirement, the enablement requirement, and the best mode requirement. Prepare students to protect possible future patents through proper documentation and security during development. Prepare students for litigation and presenting testimony. No pre-requisites. Open to non-MSU and Lifelong Education students, as well as Masters in Integrative Pharmacology students.
Online in Fall. (2 credits)
PHM 854 - Leadership & Team-Building for Researchers
Evaluation of current leadership methods. Models of leadership. Practice of specific skills and development of a plan to increase their influence and extend learning to the workplace. Course objectives: provides students with insight into their current leadership skills and areas needing improvement through 360 degree evaluation and formal temperament assessment. Students are introduced to research-based models of effective supervision practices, guiding group development, and strategic-planning. Other topics include situational leadership, virtual teams, intercultural teams, leading change & managing transitions -- skills the developing manager can apply anywhere. No pre-requisites. Open to non-MSU and Lifelong Education students, as well as Masters in Integrative Pharmacology students.
Online in Spring. (2 credits).
PHM 857 - Introduction to Project Management
Overview of formal project management culture, principles, knowledge areas, and terminology. Specific tools and techniques including work breakdown structure, earned value analysis, risk management, and quality control for managing scientific research. Students are introduced to work planning; estimating, assigning & integrative resources; risk management and quality management. Course objectives: to enable the immediate practice of project management principles increasingly used in pharmaceutical industries and biomedical research. Although of value to managers in particular, course will enable all students to participate more effectively on project teams and to better communicate project progress with colleagues, project sponsors, and industry executives. A sound introduction for those seeking CAPM or PMP certification. No pre-requisites. Open to non-MSU and Lifelong Education students, as well as Masters in Integrative Pharmacology students.Offered
Online in summer. (2 credits)
PHM 858 - The Drug Development Process
Project management standards and best practices in drug development process, including clinical trials. Introduces student to standard project management processes, tools and techniques as applied specifically to the drug development and clinical testing processes. Build capacity to participate in and lead projects at a higher level. Topics: Introduction/ review of key concepts, terminology and resources. Stage gate process for drug development. Drug discovery & pre-clinical issues: Target product profile for candidates. Project management in clinical trials. Global clinical trials: procurement, country-specifics, & alliances. Risk management in commercial biomedical research. Decision-making and problem-solving for drug development projects. Managing resources through people skills. Portfolio management for prioritizing biotech & and life sciences. Managing projects at the enterprise level. No pre-requisites. Open to non-MSU and Lifelong Education students, as well as Masters in Integrative Pharmacology students.
Online in spring. (3 credits)
PHM 870 -- Research Rotation
Individual work on selected research problems. Fall, Spring, Summer (1-4 credits)
PHM 832 -- Integrative Pharmacology Lab
Offered only to PSM Integrative Pharmacology students with 15 or more credits and GPA of 3.0 or higher. This is a hybrid course with online instruction and 1 week of on-campus exercises. (4 credits). More info.
PHM 895 -- Integrative Pharmacology Project
Offered only to PSM Integrative Pharmacology students who have completed at least the first half of their program credits and GPA of 3.0 or higher. Under the guidance of their program advisor and/or employer, students conduct individualized research and write a publishable paper. (4 credits)
PHM 899 - Master's Thesis Research
Master's thesis research. Fall, Spring and Summer of every year. (Variable credits from 1 to 8)
PHM 910 -- Seminar
Discussion of recent topics in pharmacology and toxicology by faculty or invited outside speakers. Students research reports. Fall, Spring 1(1-0)
PHM 980 -- Problems
A practical course in the use of statistical methods as applied to pharmacology. Strictly for graduate students with approval of Department. Offered throughout the year (1 to 9 credits).
PHM 999 -- Doctoral dissertation research
Fall, Spring, Summer (1 to 24 credits)
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