Alumni
PDF of MSU PharmTox Alumni Listing

2020
Thesis Title: Sex-Differences In The Immune Axis Of Perivascular Adipose Tissues: In Health And Adiposity-Induced Hypertension
Advisor: Dr. Stephanie Watts

2020
Thesis Title: The Effects Of Endocrine Disrupting Chemicals On Placental Development And Function
Advisor: Dr. Veiga-Lopez

2020
Thesis Title: The Role Of NRF2 Activation On The Murine T Cell Response To Influenza Infection
Advisor: Dr. Cheryl Rockwell

2020
Thesis Title: Mechanisms Regulating Tissue Factor:Factor VIIA-Dependent Coagulation In Liver Disease
Advisor: Dr. James Luyendyk

2020
Thesis Title: Chemerin As A Link Between Hypertension And Obesity
Advisor: Dr. Stephanie Watts

2020
Thesis Title: Investigating The Mechanism Of Obesity-Associated Estrogen Receptor-Negative Breast Cancer To Identify Novel Agents For Chemoprevention
Advisor: Dr. Jamie Bernard

2020
Thesis Title: Applying Synthetic Chemistry And Nanoparticle Delivery To Enhance Drug Efficacy And Reduce Toxicity For Cancer Prevention And Treatment.
Advisor: Dr. Karen Liby

2019
Thesis Title: The Systemic And Regional Hemodynamic Changes Responsible For 5-HT7 Receptor Mediated Hypotension
Advisor: Dr. Gregory Fink

2019
Dual Ph.D. Major (Chemistry, Pharmacology & Toxicology)
Thesis Title: The Discovery And Characterization Of Small Molecule 20S Proteasome Activators: Implications In Proteostasis Disorders
Advisor: Dr. Jetze Tepe

2019
Thesis Title: Endothelial Mineralocorticoid Receptors In Cerebrovascular And Cognitive Function In Angiotensin Il-Hypertension
Advisor: Dr. Anne Dorrance

2019
Thesis Title: Mechanisms Of GNAO1-Associated Neurological Disorders
Advisor: Dr. Richard Neubig

2019
Thesis Title: Effect Of High-Fat Diet On Sympathetic Neurotransmission In Mesenteric Vasculature In Dahl Salt-Sensitive Hypertension
Advisor: Dr. James Galligan

2019
Thesis Title: Optogenetic Analysis Of Excitatory And Inhibitory Neurotransmission In The Enteric Nervous System
Advisor: Dr. James Galligan

2019
Thesis Title: Understanding Specificity Of Small Molecule Inhibitors Of Regulators Of G-Protein Signaling (RGS) Proteins
Advisor: Dr. Richard Neubig

2019
Thesis Title: Androgen-dependent Excitability Of Mouse Ventral Hippocampal Afferents To Nucleus Accumbens Underlies Sex-Specific Susceptibility To Stress
Advisor: Dr. A.J. Robison

2018
Thesis Title: The Role of NRF2 In The Activation Of Primary CD4 Cells From Mice And Humans
Advisor: Dr. Cheryl Rockwell

2018
Thesis Title: Effects Of Human RGS2 Protein Mutations In Cardiovascular Disease
Advisor: Dr. Richard Neubig

2018
Thesis Title: Δ9- Tetrahydrocannabinol-Mediated Suppression Of The Interferon- α (IFNα) Response By Plasmacytoid Dendritic Cells And IFNα-Mediated Activation of T Cells In Healthy And Human Immunodeficiency Virus (HIV) Infected Human Subjects
Advisor: Dr. Norbert Kaminski

2017
Thesis Title: The Role Of Lateral Hypothalamic Neurotensin Neurons In Adaptive Energy Balance
Advisor: Dr. Gina Leinninger

2017
Thesis Title: Serotonergic Signaling At 5-HT 3 Receptors In Serotonin Transporter (SERT) Knockout (KO) Rat, A Sex Specific Animal Model Of Visceral Hypersensitivity
Advisor: Dr. James Galligan

2017
Thesis Title: Investigating the Role of Ventral Tegmental Area TORC2 in Stress and Stress-Induced Changes in Opiate Reward
Advisor: Dr. Michelle Mazei-Robison

2017
Thesis Title: The Role of Parkin in Maintaining Proteasome Activity Following Acute Neurotoxic Insult
Advisors: Dr. John Goudreau & Dr. Keith Lookingland

2017
Thesis Title: UCH-L1 as a Susceptibility Factor for Nigrostriatal and Mesolimbic Dopamine Neurons After Neurotoxicant Exposure and Aging
Advisors: Dr. John Goudreau & Dr. Keith Lookingland

2017
Thesis Title: Enteric Glial Cell Regulation of Oxidative Stress and Immune Homeostasis During Gastrointestinal Inflammation
Advisor: Dr. Brian Gulbransen

2016
Thesis Title: A New Role for PVAT: Regulation of Blood Vessel Function Through the Control of Norepinephrine
Advisor: Dr. Stephanie Watts

2016
Thesis Title: The effects of soluble epoxide hydrolase inhibition in a hypertensive model of cognitive impairment
Advisor: Dr. Anne Dorrance

2016
Thesis Title: Role of Aryl Hydrocarbon Receptor Polymorphisms on TCDD-mediated CYP1B1 Induction and IgM Suppression by Human B cells
Advisor: Dr. Norb Kaminski

2016
Thesis Title: Hepatoprotective functions of the hemostatic system in experimental xenobiotic-induced biliary injury
Advisor: Dr. Jim Luyendyk

2015
Thesis Title: Drug-Cytokine Cytotoxic Interaction: Relationship to Idiosyncractic, Drug-Induced Liver Injury
Advisor: Dr. Bob Roth

2014
Thesis Title: Elucidation of the Mechanisms of Interaction Between Bile Acids and the Interleukin-23/Interleukin-17 Axis During Cholestasis
Advisor: Dr. Bryan Copple

2014
Thesis Title: Mechanisms by which Remanl Denervation Chronically Lowers Blood Pressure in the Spontaneously
Hypertensive Rat
Advisor: Dr. Gregory Fink

2013
Thesis Title: Role of Central Eicosanoids in the Development of Angiotensin II-Salt Hypertension in the Rat
Advisor: Dr. Gregory Fink

2013
Thesis Title: Mechansims of Hepatocellular Apoptosis by Trovafloxacin-tumor Necrosis Factor-Alpha Interaction: An In Vitro Model of Idiosyncractic Drug-Induced Liver Injury
Advisor: Dr. Bob Roth

2013
Thesis Title: Disruption of Cellular Calcium Homeostasis and Mitochondrial Function Following Chronic Methylmercury Treatment
Advisor: Dr. Bill Atchison

2013
Thesis Title: 2,3,7,8-TCDD Alters the Development and Severity of Hepatotoxicity in a Mouse Model of Immune-Mediated Liver Injury Induced by Concanavalin A
Advisor: Dr. Patti Ganey

2013
Thesis Title: Suppression of the T-cell dependent Humoral Immune Response by Δ9-Tetrahydrocannabinol Involves Impairment of CD40-CD40 Ligand Interaction
Advisor: Dr. Norb Kaminski

2013
Thesis Title: The Role of Inflammatory Mediators in Hypertensive Remodeling of Cerebral Arteries: Focus on Perivascular Macrophages, Matrix Metalloproteinases and Tumor Necrosis Factor-α
Advisor: Dr. Anne Dorrance

2013
Thesis Title: Trovafloxacin Potentiates Lipopolysaccharide-induced Tumor Necrosis Factor-alpha in a Macrophage Cell-Line: Mechanistic Insights into Idiosyncratic Liability
Advisor: Dr. Bob Roth

2013
Thesis Title: Insights into the Effect of Tachycardia Irregularity on
Ventricular Repolarization Dynamics
Advisor: Dr. N. Bari Olivier

2013
Thesis Title: Impaired Function of PreJunctional Adenosine Receptors on Perivascular Sympathetic Nerves in Salt-Sensitive Hypertension
Advisor: Dr. Jim Galligan

2013
Thesis Title: Macrophage (MΦ)-derived Superoxide Disrupts Sympathetic Nerve Function In Deoxycorticosterone Acetate (DOCA)-Salt Hypertensive Rats
Advisor: Dr. Jim Galligan

2012
Thesis Title: Prenatal Stress Mediated Fetal Programming of Obesity in Diet-Induced Obese and Dietary Resistant Rats.
Advisor: Dr. Sheba MohanKumar

2012
Thesis Title: Endothelin-1-Induced Calcium Signaling in Artieries and Veins
Advisor: Dr. Stephanie Watts

2011
Thesis Title: Mechanism of 5-Hydroxytryptamine-Induced Hypotension
Advisor: Dr. Stephanie Watts

2011
Thesis Title: Suppression of Interleukin-2 Secretion by 15 Deoxy-Prostaglandin J2-Glycerol, a Putative Cyclooxygenase-2 Metabolite of 2-Arachidonyl Glycerol, Involves the Activation of Peroxisome Proliferator Activated Receptor Gamma
Advisor: Dr. Norb Kaminski

2011
Thesis Title: The Role of Neutrophil Elastase, Hypoxia and HIF-1α in Hepatocellular Injury
Advisor: Dr. Bob Roth

2010
Thesis Title: Sympathetic Nervous System in the Development of Mild DOCA-Salt Hypertension
Advisor: Dr. Greg Fink

2010
Thesis Title: Mechanism for 2,3,7,8-Tetrachlorodibenzo-p-Dioxin-Mediated Effects on CD40 Ligand-Induced Activation and Effector Function of Primary Human and Mouse B Cells

2010
Thesis Title: Regulation of Subsarcolemmal CA2+ Oscillations and Myogenic Tone in the Microcirculation
Advisor: Dr. William Jackson

2009
Thesis Title: In Vivo and In Vitro Mechanisms for Disruption of the Toll-Like Receptor Activated Primary Immunoglobulin M Response by 2,3,7,8-Tetrachlorodibenzo-p-Dioxin (TCDD)
Advisor: Dr. Norb Kaminski

2008
Thesis Title: Enhanced Adrenergic Sensitivity of Mesenteric Veins Compared to Arteries and its Relation to Calcium Utilization and Handling

2008
Thesis Title: Neurogenic Mechanisms of Salt-Sensitive Hypertension
Advisor: Dr. Greg Fink

2008
Thesis Title: The Effects of Chronic Activation of Endothelin ETB Receptors on Blood Pressure, Venomotor Tone, Neurohumoral Activity, and Oxidative Stress
Advisor: Dr. Greg Fink

2008
Thesis Title: The Role of Pax5, Blimp-1 and AP-1 in the Suppression of B Cell Differentiation of TCDD
Advisor: Dr. Norb Kaminski

2008
Thesis Title: Inflammation and Idiosyncratic Drug Reactions: Inflammatory Mechanisms and Interactions in a Murine Model of Trovafloxacin Hepatotoxicity
Advisor: Dr. Bob Roth

2007
Thesis Title: Characterization of Delta-9-Tertrahydrocannabinol-Mediated Alterations in Leukocyte and Airway Epithelial Cell Responses to a Primary Challenge with Influenza A/PR/8/34 in C57BL/6 Wild Type and CB1/CB2 Receptor-Null Mice
Advisor: Dr. Norb Kaminski

2006
Thesis Title: Altered Pattern of Methylation in Gene-specific and GC-rich Regions of DNA Underlie Tumorigenesis
Advisor: Dr. Jay Goodman

2006
Thesis Title: Signal Transduction Pathways Involved in the Upregulation of Cyclooxygenase-2 by 2,2',4,4',-Tetrachlorobiphenyl
Advisor: Dr. Patti Ganey

2006
Thesis Title: The Presence of A Local Serotonergic System in Peripheral Arteries
Advisor: Dr. Stephanie Watts

2006
Thesis Title: Endothelin A (ETA) and ETB Receptor Interaction in Arteries and Veins
Advisor: Dr. Stephanie Watts

2005
Thesis Title: Design, Management, and Quality Control of Toxicogenomics Experiments
Advisor: Dr. Jim Galligan

2005
Thesis Title: Alpha-1 Adrenergic Receptor Function and Protein Expression in Arteries and Veins from Normal and Hypertensive Mice
Advisor: Dr. Jim Galligan

2005
Thesis Title: Involvement of TRPC1 in the Cannabinoid-Mediated Elevation in Intracellular Calcium in T Cells
Advisor: Dr. Norb Kaminski

2005
Thesis Title: Inhibition of Interleukin-2 Secretion by 2-Arachidonyl Glycerol and Anandamide Occurs through Perixsome Proliferator Activated Receptor Gamma Independently of the Cannabinoid Receptors
Advisor: Dr. Norb Kaminski

2005
Thesis Title: Neurohumoral Control of Splanchnic Circulationin DOCA-Salt Hypertensive Rats
Advisor: Dr. Greg Fink

2005
Thesis Title: Low-potency Poly (ADP-Ribose) Polymerase Inhibitors (Ip-PARPi) Induce Insulin Gene Expression through the Upregulation of MafA in INS-1 Pancreatic-Cells
Advisor: Dr. Karl Olson