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PHM 450 - Introduction to Chemical Toxicology**


This online course provides an introduction to mammalian toxicology. The course includes an overview of the general principles of toxicology, toxicokinetics, and mechanisms of
toxicity in major organ systems. The course also includes discussion of selected toxic agents. 

Individuals not affiliated with the University may enroll in this course as a Lifelong Education Student. Introduction to Chemical Toxicology is open to anyone with a prerequisite knowledge of biology and chemistry, and an interest in learning more
about toxicology.


  • Cellular and molecular mechanisms of toxicity
  • Toxicokinetics
  • Mutagenesis and carcinogenesis
  • Hepatic and renal toxicology
  • Neurotoxicology and immunotoxicology
  • Cardiovascular and respiratory toxicology
  • Teratogenesis
  • Toxicology within the drug development process
  • Pharmaceuticals as toxicants
  • Environmental toxicology
  • Chemical risk assessment


BS 161, and BS 162, and CEM 251


Required for online sections of this course:

  • Publisher ‏ : ‎ McGraw Hill / Medical; 4th edition (February 23, 2021)
  • Language ‏ : ‎ English
  • Paperback ‏ : ‎ 640 pages
  • ISBN-10 ‏ : ‎ 1260452298
  • ISBN-13 ‏ : ‎ 978-1260452297


  • Dr. Tobi Limke Received her PhD in Pharmacology & Toxicology-Environmental Toxicology from Michigan State University. She also holds an MBA from the University of Maryland. A postdoctoral fellow at the National Institute on Aging at the National Institutes of Health in Baltimore, MD, Dr. Limke has experience working with classic pharmaceutical and biotechnology companies in both scientific and business roles. Currently, she works as a freelance technical marketing consultant for the biopharmaceutical industry.
  • Dr. Belinda Hawkins holds a PhD in Pharmacology & Toxicology-Environmental Toxicology from Michigan State University. She works for the US-EPA in Cincinnati, OH. She is currently Chief of the Chemical Risk Assessment Branch within EPA’s National Center forEnvironmental Assessment.
  • Dr. Colleen Hegg 


Online:  Summer, Fall, Spring / Dr. Tobi Limke, Dr. Belinda Hawkins

On-campus: Spring/
Dr. Keith Lookingland




  • Undergraduate Minor
  • Online MS programs

Sections available

  • 730 MSU program Students
  • 731 Lifelong In-State
  • 732 Lifelong Out-State