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PHM 483 - Chemotherapy of Infectious Diseases*


Fall, Spring of every year, starting Fall 2018.
[formerly "Antimicrobial Chemotherapy"]

In the treatment of infectious diseases, the major goal is to kill microbes, or at least disrupt their ability to propagate, so the immune system can clear them. While simple in principle, problems arise because the drugs must kill the microbes but spare the host; this is the principle of selective toxicity. Secondly, microbes tend to develop resistance to drugs that are initially effective. The problem of resistance is both grave and unavoidable. As a consequence, there is a constant requirement for new agents, as well as practices that ensure continued effective prescribing of antimicrobial agents.

This course will focus on the study of major classes of antibiotics and chemotherapy of bacterial, viral, fungal and parasitic infections.  Up-to-date drugs of choice for infectious disease treatment and pharmacologic properties will also be featured in this course.   The course is designed to meet the requirements of those studying biology, microbiology, medicine, nursing, premed, and allied health sciences at both undergraduate and graduate levels.  

PHM 483 Course Modules

  • Antibiotics
  • Antiviral agents
  • Antifungal agents
  • Antiparasitic agents
  • Antimicrobial resistance
  • Biology and principles of infectious diseases
  • Pharmacokinetic and pharmacodynamics principles
  • Treatment of respiratory tract infections
  • Treatment of urinary tract infections
  • Treatment of sexually transmitted diseases
  • Treatment of gastrointestinal infections
  • Treatment of serious bloodstream infections
  • Treatment of central nervous system infections
  • Treatment of parasitic infections

PHM 483 Learning Outcomes

  • Identification of antimicrobial class:
    • Antibiotics
    • Antiviral agents
    • Antifungal agents
    • Antiparasitic agents
  • Disease epidemiology
  • Disease pathogenesis and immune response
  • Clinical features and laboratory work up
  • Pharmacologic properties (PK and PD) of antimicrobial agents
  • Mechanisms of antimicrobial resistance
  • Biological characteristics of infectious diseases
  • Principles of infectious diseases
  • Chemotherapy of infectious diseases 

Required Textbook

Picture of Antimicrobial Chemotherapy Book
  • Paperback: 450 pages
  • Publisher: Oxford University Press; 7 edition (July 5, 2015)
  • ISBN-10: 0199689776
  • ISBN-13: 978-0199689774



Dr. Reza Nassiri
served as Associate Dean of Global Health and Director of Institute of International Health at MSUCOM.  He is currently a faculty member at the Departments of Pharmacology and Toxicology and Family and Community Medicine.  His teaching expertise includes the pharmacology of infectious diseases and tropical medicine.  Scholarly activities include global health issues in the context of infectious diseases, tropical diseases, and public health.  His research interests are biochemical pharmacology of antiviral agents, antibiotic resistance, One Health, HIV/AIDS, and viral hepatitis.


Online Fall & Spring




  • Undergraduate

  • MS in Pharmacology & Toxicology

  • MS in Integrative Pharmacology