PHM 816 - Integrative Toxicology: Mechanisms, Pathology and Regulation
Offered odd-number years only
Biochemical, molecular, and physiological mechanisms of toxicology. Functional and pathological responses of major organ systems to chemical insult. Mechanisms of mutagenesis, carcinogenesis, and reproductive toxicology. Concepts in risk and safety assessment.
Some biology and/or chemistry is strongly suggested. PHM819 or PHM 801
- Introduction to toxicologic pathology; general concepts
- Pathways to cell death; oxidative stress; hypoxia and chemical hypoxia
- Pathology of chemical-induced inflammation and cellular injury; adaptation and repair
- Receptor-mediated toxicity
- Pathology of chemical-induced cancer, and neurotoxicity
- Mutagenesis and carcinogenesis
- Toxicology of the immune system
- Liver toxicology/pathology
- Respiratory system toxicology/pathology
- Genetic susceptibility
- Risk assessment -- introduction
- Risk/safety assessment -- noncarcinogens, pollutants in air/water, cancer
- Drug discovery and regulatory toxicology
- Epigenetic, transgenerational effects of chemicals
No textbooks required; electronic materials utilized.
Dr. Patricia Ganey received her PhD in Pharmacology and Toxicology at Michigan State University. Her interests focus on the role of inflammation in druginduced liver injury; interaction of environmental chemicals with inflammatory response.
Dr. Jack Harkema received his DVM from Michigan State University and his PhD from the University of Calif-Davis. His interests focus on respiratory pathology and inhalation toxicology, mechanisms of airway epithelial injury, adaptation and repair after exposure to air pollutants, toxicologic pathology, upper airway toxicology & pathology.
Fall, odd-numbered years
Animal Science, Biochemistry and Molecular Biology, Pathobiology & Diagnostic Investigation
Administered by Pharmacology & Toxicology