PHM 816 - Integrative Toxicology: Mechanisms, Pathology and Regulation


Offered odd-number years only

Biochemical, molecular, and physiological mechanisms of toxicology. Functional and pathological responses of major organ systems to chemical insult. Mechanisms of mutagenesis, carcinogenesis, and reproductive toxicology. Concepts in risk and safety assessment.

Recommended Background

Some biology and/or chemistry is strongly suggested. PHM819 or PHM 801


  • Introduction to toxicologic pathology; general concepts
  • Pathways to cell death; oxidative stress; hypoxia and chemical hypoxia
  • Pathology of chemical-induced inflammation and cellular injury; adaptation and repair
  • Receptor-mediated toxicity
  • Pathology of chemical-induced cancer, and neurotoxicity
  • Mutagenesis and carcinogenesis
  • Toxicology of the immune system
  • Liver toxicology/pathology
  • Neurotoxicology
  • Respiratory system toxicology/pathology
  • Genetic susceptibility
  • Risk assessment -- introduction
  • Risk/safety assessment -- noncarcinogens, pollutants in air/water, cancer
  • Drug discovery and regulatory toxicology
  • Epigenetic, transgenerational effects of chemicals

Recommended Textbooks

No textbooks required; electronic materials utilized.


Dr. Patricia Ganey received her PhD in Pharmacology and Toxicology at Michigan State University. Her interests focus on the role of inflammation in druginduced liver injury; interaction of environmental chemicals with inflammatory response.

Dr. Jack Harkema received his DVM from Michigan State University and his PhD from the University of Calif-Davis. His interests focus on respiratory pathology and inhalation toxicology, mechanisms of airway epithelial injury, adaptation and repair after exposure to air pollutants, toxicologic pathology, upper airway toxicology & pathology.


Fall, odd-numbered years







Sections available


Interdepartmental with

Animal Science, Biochemistry and Molecular Biology, Pathobiology & Diagnostic Investigation

Administered by Pharmacology & Toxicology