Description

Biochemical, molecular, physiological mechanisms and assessment of neurotoxicity. Factors predisposing the nervous system to selective toxicants. Pathophysiology and models of toxicant-induced neurodegenerative diseases.

Topics

• General principles of toxicology
• Review of toxicokinetics
• Overview of normal structure and function of the nervous system
• Aspects of normal cellular neurophysiology
• Mechanisms of neurotoxicity
• Glial-neuronal interactions and neuro- inflammation
• Neurotransmission-associated neurotoxicity
• Models of neurodegenerative disease
• Neurotoxicity assessment
• Pharmacological neuroprotective strategies

Pre-requisites

PHM 819 and PHM 450 or equivalent

pharmacology & toxicology courses;

undergraduate biochemistry and cell biology

Recommended Textbooks

Casarett & Doull's Toxicology: The Basic Science of Poisons

8th Edition
McGraw-Hill Professional
Publisher: McGraw-Hill Education / Medical; 8 edition (June 19, 2013) Language: English
ISBN-10: 0071769234    
ISBN-13: 978-0071769235

INSTRUCTOR

Dr. Colleen Hegg