Description

Biochemical, molecular, physiological mechanisms and assessment of neurotoxicity. Factors predisposing the nervous system to selective toxicants. Pathophysiology and models of toxicant-induced neurodegenerative diseases.

Topics

• General principles of toxicology
• Review of toxicokinetics
• Overview of normal structure and function of the nervous system
• Aspects of normal cellular neurophysiology
• Mechanisms of neurotoxicity
• Glial-neuronal interactions and neuro- inflammation
• Neurotransmission-associated neurotoxicity
• Models of neurodegenerative disease
• Neurotoxicity assessment
• Pharmacological neuroprotective strategies

Pre-requisites

PHM 819 and PHM 450 or equivalent

pharmacology & toxicology courses;

undergraduate biochemistry and cell biology

Recommended Textbooks

Casarett & Doull's Toxicology: The Basic Science of Poisons

8th Edition
McGraw-Hill Professional
Publisher: McGraw-Hill Education / Medical; 8 edition (June 19, 2013) Language: English
ISBN-10: 0071769234    
ISBN-13: 978-0071769235

Instructor(s)

Dr. Keith Lookingland earned his PhD from the University of Maryland. His interests encompass the areas of development of neuroprotective pharmacological agents and strategies for the treatment of dopamine neurodegenerative disorders including Parkinson’s Disease and Restless Leg Syndrome