Description

Practical PK/PD Modeling and Simulation for Drug Development.

This course will employ hands on PK/PD modeling, using published graphical user interfaces (GUIs) and the MatLabⓇ SimBiologyⓇ platform for model building and exploration. Students will be introduced to modeling software examples applicable to biology and medicine and gain practical experience using software to explore outcomes under varying conditions. A student should acquire an overview of working in a graphical user interface environment to set up and solve models pertinent to pharmacology and toxicology. The focus is on implementing models, not creating them. This is not a comprehensive modeling course. Grading will be based on reports/assignments.

Textbooks

No textbook required.

Software

MatLabⓇ and SimBiologyⓇ available free to all MSU students

Course Topics

• Setting up Matlab
• Drag and Drop model building
• Non-compartment parameter estimation
• Kinetic examples
  • Hemoglobin oxygenation/release
  • Hb oxidation/metHb reduction
  • CO competitive binding
• One compartment PK models
• Two compartment PK models
• PD
  • Activity
  • Toxicity
• Systems pharmacology
  • Focus on insulin & diabetes
• Comparative physiology
  • Parameters that change across species

(course topics subject to change)

Course Information

Pre-requisites

• PHM 819 or equivalent
• Course Number: PHM 980
• Sections Available: 736 (online)
• Semesters: Fall 2019
• Credits: 1 credit

Successful completion of this course will count as 1 credit of science elective toward the MS degree. 

It may not substitute for either of the required 2 credits of PHM 980 section 799, Special Problems in Pharmacology and Toxicology (writing your final/capstone review paper).

Instructors

David A Juckett, PhD
Received his MS and PhD in Biophysics from MSU and as a Postdoctoral Fellow in Biochemistry at the University of Michigan and a research fellow at St. Jude
Children’s Research Hospital.

He served as the Associate Director of the Barros Research Institute at MSU, where he oversaw development of anti-cancer drugs and vaccine adjuvants. He has a high interest and research activity in mathematical modeling and biomedical informatics.
Dr. Juckett also teaches PHM 858 The Drug Development Process.