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PHM 833 - Gastrointestinal And Liver Pharmacology & Toxicology*


Specific drugs and their mechanisms of action in the treatment of gastrointestinal and liver diseases. Toxic effects of drugs and other xenobiotics on the gastrointestinal tract, including the liver.


  • Gastrointestinal anatomy and physiology
  • Neurohumoral control of gastrointestinal motility
  • Pharmacotherapy of gastrointestinal motility disorders
  • Neurohumoral control of gastric acid secretion
  • Pharmacotherapy of acid secretory disorders
  • Neurohumoral mechanisms of nausea and vomiting
  • Pharmacotherapy of nausea and vomiting
  • Inflammatory bowel disease
  • Pharmacological treatment of inflammatory bowel disease
  • Pathophysiology of pancreatic acid and biliary disorders
  • Liver physiology
  • Drug-induced liver toxicology and endogenous protective mechanisms
  • Alcohol-induced liver injury
  • Hepatitis virus subtypes and liver injury
  • Chemotherapy for treatment of hepatitis infections
  • Preclinical, clinical and post-marketing assessment of drug-induced hepatotoxicity


PHM 819

Recommended Textbooks

No textbook required; electronic materials utilized.


Dr. Robert Roth is a professor with the department of Pharmacology & Toxicology, as well as the Graduate Program Director for Environmental and Integrative Toxicological Sciences at the Institute for Integrative Toxicology at Michigan State University.

"Graduate students and postdoctoral fellows in my laboratory research inflammation as a determinant of susceptibility to the toxic effects of drugs and other chemical agents." [read more]


Online Spring




  • MS/Pharmacology & Toxicology
  • MS/Integrative Pharmacology
  • Grad Cert/ SafetyPhm



Sections available

  • 730 MSU program Students
  • 731 Lifelong In-State
  • 732 Lifelong Out-State