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PHM 838 - Pharmacogenomics*

Description

Pharmacogenomics is one of the most rapidly
growing areas of pharmacology. The promise of
individualized (personalized) health care and
treatment strategies warrants understanding of
common and rare genetic mutations that impact disease risk and stratify treatment options.

In this course we will dissect the basics of
genomics and its interplay with traits, efficacy,
toxicity, kinetics and dosage involving drugs and drug pathways. The course will cover the
background of pharmacogenomics through
lectures and literature discussions, with hands-on learning through pharmacogenomic database searches and a related student project.

Textbooks

Concepts in Pharmacogenomics
2nd edition
Martin M Zdanowicz
American Society of Health-System
Pharmacists, 2017
 

Course Topics

  • Genomics basics: inheritance, linkage
    disequilibrium, genome browser extraction, gene annotation, gene regulation
  • expression Quantitative Trait Loci (eQTLs)
  • Genome-Wide Associate Studies (GWAS)
  • Population genomics
  • Pharmacogenomic variants in public
    databases (pharmGKB)
  • Pharmacology systems mapping and
    extraction of human variants

Course Information

Pre-requisites:

  • Knowledge of general principles of pharmacology, physiology, and genetics.

Successful completion of this course will count as 2 credits of science elective toward the MS degree. 

FACULTY
Jeremy Prokop, PhD
Received his PhD in Integrated Biosciences from the U of Akron and was a Postdoctoral Fellow in
Molecular Genetics at the Medical College of
Wisconsin. His research focuses on the genetic
mechanisms of disease. The lab utilizes computational tools for examining the roles of genomic variants on protein function and extends this research into in vitro models to gain insight to predict disease causation and treatment.

Semester

Online Fall 

Credits

2

Programs

  • Online Graduate / MS

Type

Online Graduate / MS