Description

Mechanistic concepts and techniques of toxicology at the cellular and molecular levels. Various molecular events and cellular modifications that result from and/or are associated with chemically/environmentally induced toxicity and disease.

Topics

• Molecular techniques in toxicology
• Cellular techniques in toxicology
• Cytochrome P450
• Phase I-Metabolism of toxicants
• Phase II-Conjugation of toxicants
• Xenobiotic transporters
• Mechanisms of cell death
• Mitochondrial dysfunction
• Oxidative stress
• Reactive oxygen species
• Toxicity of metals
• DNA damage and mutagenesis/DNA repair

Pre-requisites

PHM 450 or equivalent introductory toxicology course required.

Recommended Textbooks

Molecular and Biochemical Toxicology
4th edition.
Smart, Hodgson.
Wiley

NOTE: This book is available
electronically through the MSU library.

Instructor(s)

Dr. Jane Maddox is the Director of the online MS programs in Pharmacology & Toxicology. She received her DVM from Michigan State University. Following a few years of private practice, she earned her PhD in Pathobiology from Pennsylvania State University and held a postdoctoral position at Harvard. Her research interests include inflammation and mechanisms of druginduced liver injury.