PHM 841 - Cellular And Molecular Toxicology

Description

Mechanistic concepts and techniques of toxicology at the cellular and molecular levels. Various molecular events and cellular modifications that result from and/or are associated with chemically/environmentally induced toxicity and disease.

Topics

  • Molecular techniques in toxicology
  • Cellular techniques in toxicology
  • Cytochrome P450
  • Phase I-Metabolism of toxicants
  • Phase II-Conjugation of toxicants
  • Xenobiotic transporters
  • Mechanisms of cell death
  • Mitochondrial dysfunction
  • Oxidative stress
  • Reactive oxygen species
  • Toxicity of metals
  • DNA damage and mutagenesis/DNA repair

Pre-requisites

PHM 450 or equivalent introductory toxicology course required.

Recommended Textbooks

book cover

Molecular and Biochemical Toxicology
4th edition.
Smart, Hodgson.
Wiley

 

 

Instructor(s)

Dr. Jane Maddox is the Co-Director of the online MS program in Pharmacology & Toxicology. She received her DVM from Michigan State University. Following a few years of private practice, she earned her PhD in Pathobiology from Pennsylvania State University and held a postdoctoral position at Harvard. Her research interests include inflammation and mechanisms of druginduced liver injury.

Semesters

Online Fall

Credits

3

Programs

  • MS/Pharmacology
  • MS/Toxicology
  • MS/General
  • PSM
  • Grad Cert/ SafetyPhm

Type

Science

Sections available

  • 730 MSU program Students
  • 731 Lifelong In-State
  • 732 Lifelong Out-State