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PHM 980, Section 005 - Dose-response Relationships in Toxicology & Risk Assessment - Concepts, Complexities and Controversies

Description

“The dose makes the poison!” This paraphrase from Paracelsus in the 1500s remains today the most important principle in toxicology.

Dose-response relationships underlie approaches to understanding toxicologic mechanisms and to assessing risk from exposure to environmental pollutants, drugs and other chemicals.

This course will begin with general information about dose-response terminology and concepts before delving into issues and implications surrounding the threshold concept, nonmonotonic dose-response relationships, hormesis, how dose-response characteristics are used in risk assessment, and more.

Enroll to learn about and discuss important nuances of dose-response and how they give rise to challenges and controversies in assessing risk from chemical exposure. This course will add to your sophistication as a thinker in biological science!

PRE-REQUISITES

At least one graduate course in physiology, biochemistry/molecular biology. Completion of PHM 801/802 or equivalent is recommended but not required. Students who have not completed PHM 801/802 should contact a course moderator before enrolling.

EVALUATION

Each student will be evaluated based on attendance, quality of assigned presentation(s) and participation in discussions.

Instructors

Semesters

Fall 2020 only at this time.

Credits

1

Fulfills the EITS Topics in Toxicology requirement.

Sections available