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Current Students


Bana Abolibdeh

Kevin Chen

Shelby DeChow

Taylor Fiolek

Bronson Gregory

Chauncey Splichal

Anna Stoll

Duffy, M. F., Collier, T. J., Patterson, J. R., Kemp, C. J., Luke Fischer, D., Stoll, A. C., & Sortwell, C. E. (2018). Quality Over Quantity: Advantages of Using Alpha-Synuclein Preformed Fibril Triggered Synucleinopathy to Model Idiopathic Parkinson's Disease. Frontiers in neuroscience12, 621. doi:10.3389/fnins.2018.00621


Past Students


Janice Diaz-Otero

  1. Diaz-Otero JM, Garver H, Fink GD, Jackson WF, Dorrance AM. Aging is associated with changes to the biomechanical properties of the posterior cerebral artery and parenchymal arterioles.Am J Physiol Heart Circ Physiol. 2016 Feb 1;310(3):H365-75. doi: 10.1152/ajpheart.00562.2015. Epub 2015 Dec 4. PMID: 26637558

  2. Diaz-Otero JM, Dorrance AM.  2015, The effects of mineralocorticoid receptor blockade on cerebral arteries post stroke.  2015 International Stroke Conference.  
  3. Diaz-Otero JM, Jackson WF, Dorrance AM.  2015, Aging alters vascular stiffness in the posterior cerebral artery in C57bl/6 mice.  2015 International Stroke Conference.

Sean Nguyen

  1. Nguyen, S, Zhou, H, Pestka, JJ. 2015, ELISA for Bioactive Cholecystokinin—A Novel Biomarker for Enteroendocrine Cell Disruption. (March, 2015) Society of Toxicology Annual Meeting, San Diego, CA.
  2. Lokken, A, Nguyen, S, Ralston, A.  2015, OCT4 promotes pluripotency and differentiation to primitive endoderm. (May, 2015) Poster presented at the 5th Annual Michigan Alliance for Reproductive Technologies and Science, Grand Rapids, MI. 

Di Zhang



Nadia Ayala-Lopez

  1. Ayala-Lopez N, Jackson WF, Burnett R, Wilson JN, Thompson JM, Watts SW. 2015 Organic cation transporter 3 contributes to norepinephrine uptake into perivascular adipose tissue. Am J Physiol Heart Circ Physiol. 2015 Dec 1;309(11):H1904-14. doi: 10.1152/ajpheart.00308.2015. Epub 2015 Oct 2. PMID:26432838

  2. Ayala-Lopez, N, Martini M, Jackson WF, Darios E, Burnett R, Seitz B, Fink GD, Watts SW.  2014, Perivascular adipose tissue contains functional catecholamines. Pharmacol Res Perspect. 2014 Jun 1;2(3):e00041. PMID: 24904751. PMCID: PMC4041285.
  3. Ayala-Lopez N, Matin N, Dorrance AM. Physiologist. 2013, Mentoring 101: training for the future.  Sep;56(5):153-4.  PMID: 24175397.  PubMed - indexed for MEDLINE. 

  4. Ayala-Lopez N, Deborah K. 2013, Therapeutic Drug Monitoring., Clinical Chemistry: Principles, Techniques and Correlations, Eds. Bishop, Fody, and Schoeff. Philadelphia: Lippincott Williams & Wilkins, 7th edition, February, 2013. p626-644. Textbook chapter.

  5. Ayala-Lopez, N, Burnett, R, Thompson, J, and Watts, S. 2014, Existence of Functional Norepinephrine Transport in Perivascular Adipose Tissue. Hypertension 2014; 64: A333. 

  6. Ayala-Lopez, N, Jackson, W, Wilson, J, and Watts, S. 2014, ASP+ Reveals Potential Function of the Serotonin Transporter in Perivascular Adipose Tissue. The FASEB Journal 2014; 28 (1), 1170.8.

Nadine El-Ayache

  1. El-Ayache N, Galligan JJ. 5-HT3 receptor signaling in a rat model of sex specific visceral sensitivity.  FASEB J. 29:851.3, 2015. 
  2. Mecca A, El-Ayache N, Galligan JJ.  Corticotrophin releasing hormone (CRH) expression ins an animal model of visceral hypersensitivity.  FASEB J 29: 849.3, 2015.  

Marion France

  1. Duran B, Brocenschi RF, France M, Galligan JJ, Swain GM. 2014,  Electrochemical activation of diamond microelectrodes: implications for the in vitro measurement of serotonin in the bowel. Analyst 139: 3160- 6, 2014. PMCID: PMC4266237.
  2. France M, Bhattarai Y, Galligan JJ, Xu H. 2012, Impaired propulsive motility in the distal but not proximal colon of BK channel β1-subunit knockout mice. Neurogastroenterol Motil 2012; 24: e450-9. PMCID: PMC3425659.

  3. France M, Skorich E, Kadrofske M, Swain G, Galligan JJ. 2015, Sex-related differences in small intestinal transit and serotonin dynamics in high fat diet-induced obesity in mice. Exp Physiol 2016 Jan;101(1):81-99. doi: 10.1113/EP085427. Epub 2015 Oct 28.

Rosa Jaiman-Cruz

  1. Jaiman, R J, & Atchison WD. 2013, The Effect of Methylmercury on Levels of Excitatory Amino Acid Transporter 2 (EAAT2) of the Molecular and Granular Layer of the Cerebellum. Poster presented at The Gordon Research Conference on Cellular & Molecular Mechanisms of Toxicity, Andover, NH.
  2. Jaiman, R J, & Atchison WD. 2014, Comparative Effects of Methylmercury on Cerebellar and Cortical Astrocytes. Poster presented at The Society of Toxicology, Phoenix, AZ.
  3. Jaiman, R J, & Atchison WD. 2014, . Comparative Effects of Methylmercury on Cerebellar and Cortical Astrocytes of Neonatal and Young Mice. Poster presented at The Society for Neuroscience, Washington, DC.

Sophia Kaska

  1. Vialou V, Thibault M, Kaska S, Cooper S, Gajewski P, Eagle A, Mazei-Robison M, Nestler EJ, Robison AJ.  2015, Differential induction of FosB isoforms throughout the brain by fluoxetine and chronic stress. Neuropharmacology. 2015 Jul 9;99:28-37. doi: 10.1016/ j.neuropharm.2015.07.005. [Epub ahead of print] PMID: 26164345.
  2. Heller EA, Kaska S, Fallon B, Ferguson D, Kennedy PJ, Neve RL, Nestler EJ, Mazei-Robison MS. 2015, Morphine and cocaine increase serum- and glucocorticoid-inducible kinase 1 activity in the ventral tegmental area.  J Neurochem. 2015 Jan;132(2):243-53. doi: 10.1111/jnc.12925. Epub 2014 Aug 26. PMID: 25099208. PMCID: PMC4302038.
  3. Kaska, S, Cooper, S, Kechner, M, Mazei-Robison, MS.  2014,  Determining a Role for Rictor in Susceptibility to Stress and Morphine Reward and Consumption. Neuropsychopharmacology, 2014 December. 39:S112-S290. 
  4. Kaska, S, Kechner, M, Mazei-Robison, MS. 2015, Role of Ventral Tegmental Area TORC2 Signaling in Stress-Induced Morphine Reward. The FASEB Journal, 2015 April. 29:768.8. 

Teri Lansdell

  1. Walters JL, Lansdell TA, Lookingland KJ, Baker LE, 2015 The effects of gestational and chronic atrazine exposure on motor behaviors and striatal dopamine in male Sprague-Dawley rats. Toxicol Appl Pharmacol. 2015 Dec 1;289(2):185-92. doi: 10.1016/j.taap.2015.09.026. Epub 2015 Oct 9. PMID: 26440580
  2. Lansdell TA, Lookingland KJ, Goudreau JL. 2015, Temporal dynamics of 20S and 26S proteasome activities in brain regions containing differentially susceptible central dopaminergic neurons following acute neurotoxicant administration. Society for Neuroscience Annual Meeting. Chicago, Il. 

  3. Lansdell TA, Lookingland KJ, Goudreau JL.  2015, Maintenance of 26S proteasome activity is dependent upon parkin in brain regions containing tuberoinfundibular but not nigrostriatal dopamine axon terminals following neurotoxicant exposure.  Van Andel Institute’s Grand Challenges in Parkinson’s Disease. Grand Rapids, Michigan, United States.

  4. Lansdell, TA, Goudreau, JL, Lookingland, KJ. 2014, The effects of acute neurotoxicant exposure on parkin expression and proteasome activity in brain regions containing differentially susceptible dopaminergic neurons, Soc. Neurosci., 695.15.

  5. Lansdell, T, Goudreau, JL, Lookingland, KJ. 2014, Exposure to neurotoxicant results in parkin dependent changes in proteasome activity in brain regions containing differentially susceptible dopaminergic neurons, American College Toxicology (ACT) 35th Annual Meeting,

  6. Lansdell, T, Goudreau, JL, Lookingland, KJ.  2015, Decreased proteasome activity in brain regions containing nigrostriatal dopamine neurons occurs through a parkin independent process, American College Toxicology (ACT) 36th Annual Meeting, 

Ashley Maiuri

  1. Beggs KM, Maiuri AR, Fullerton AM, Poulsen KL, Breier AB, Ganey PE, Roth RA.  2015, Trovafloxacin-induced replication stress sensitizes HepG2 cells to tumor necrosis factor-alpha-induced cytotoxicity mediated by extracellular signal-regulated kinase and ataxia telangiectasia and Rad3-related. Toxicology. 2015 May 4;331:35-46. doi: 10.1016/j.tox.2015.03.002. Epub 2015 Mar 5. PMID: 25748550. PMCID: PMC4445241.
  2. Maiuri AR, Breier AB, Gora LF, Parkins RV, Ganey PE, Roth RA.  2015, Cytotoxic Synergy Between Cytokines and NSAIDs Associated With Idiosyncratic Hepatotoxicity Is Driven by Mitogen-Activated Protein Kinases. Toxicol Sci. 2015 Aug;146 (2):265-80. doi: 10.1093/toxsci/kfv091. Epub 2015 May 7. PMID: 25953702.  

Nusrat Matin

  1. Phillips AA, Matin N, Frias B, Zheng MM, Jia M, West C, Dorrance AM, Laher I, Krassioukov AV. Rigid and remodelled: cerebrovascular structure and function after experimental high-thoracic spinal cord transection. J Physiol. 2016 Mar 15;594(6):1677-88. doi: 10.1113/JP270925. Epub 2016 Jan 18. PMID: 26634420

  2. Matin N, Fisher C, Jackson WF, Dorrance AM. 2015, Bilateral common carotid artery stenosis in hypertensive rats impairs dilation in penetrating arterioles and posterior communicating arteries. Am J Physiol Heart Circ Physiol. 2016 May 15;310(10):H1321-9. doi: 10.1152/ajpheart.00890.2015. Epub 2016 Mar 11
  3. Dorrance AM, Matin N, Pires PW. 2014, The effects of obesity on the cerebral vasculature. Curr Vasc Pharmacol. May 2014;12(3):462-72. Review. PMID: 24846235.  PubMed – indexed for MEDLINE. 
  4. Ayala-Lopez N, Matin N, Dorrance AM. 2013, Mentoring 101: training for the future. Physiologist. 2013 Sep;56(5):153-4. PMID: 24175397.  PubMed - indexed for MEDLINE.
  5. Pires PW, Dams Ramos CM, Matin N, Dorrance AM2013, The effects of hypertension on the cerebral circulation.  Am J Physiol Heart Circ Physiol. 2013 Jun 15;304(12):H1598-614. doi: 10.1152/ajpheart.00490.2012. Epub 2013 Apr 12. Review. PMID: 23585139.  PMCID: PMC4280158.
  6. Pires PW, Matin N, Garver H, Dorrance AM. 2013, Mechanisms of endothelial dysfunction in penetrating cerebral arterioles of DOCA-salt hypertensive rats. FASEB J 27: 678.7, 2013. 
  7. Matin N, Pires PW, Garver H, Dorrance AM. 2013, Remodeling and impaired dilation in middle cerebral arteries from Deoxycorticosterone acetate (DOCA)-salt rats. FASEB J 27: 700.5, 2013. 
  8. Matin N, Neros G, McClain J and Dorrance AM. 2013, Posterior communicating artery remodeling in chronic cerebral hypoperfusion .FASEB J. 27: 709.7, 2013. 
  9. Matin N, Dorrance AM. 2014, Captopril treatment improves endothelium dependent dilation and middle cerebral artery remodeling in hypertensive rats. FASEB J. 28: 841.8, 2014.

Rance Nault

  1. Joshi N, Kopec AK, Ray JL, Cline-Fedewa H, Nawabi A, Schmitt T, Nault R, Zacharewski TR, Rockwell CE, Flick MJ, Luyendyk JP. Fibrin deposition following bile duct injury limits fibrosis through an αMβ2-dependent mechanism.Blood. 2016 Jun 2;127(22):2751-62. doi: 10.1182/blood-2015-09-670703. Epub 2016 Feb 26.

  2. Nault R, Fader KA, Kirby MP, Ahmed S, Matthews J, Jones AD, Lunt SY, Zacharewski TR. Pyruvate Kinase Isoform Switching and Hepatic Metabolic Reprogramming by the Environmental Contaminant 2,3,7,8-Tetrachlorodibenzo-p-Dioxin. Toxicol Sci. 2016 Feb;149(2):358-71. doi: 10.1093/toxsci/kfv245. Epub 2015 Nov 17.

  3. Fader KA, Nault R, Ammendolia DA, Harkema JR, Williams KJ, Crawford RB, Kaminski NE, Potter D, Sharratt B, Zacharewski TR. 2,3,7,8-Tetrachlorodibenzo-p-Dioxin Alters Lipid Metabolism and Depletes Immune Cell Populations in the Jejunum of C57BL/6 Mice. Toxicol Sci. 2015 Dec;148(2):567-80. doi: 10.1093/toxsci/kfv206. Epub 2015 Sep 16.

  4. Ong CB, Kumagai K, Brooks PT, Brandenberger C, Lewandowski RP, Jackson- Humbles DN, Nault R, Zacharewski TR, Wagner JG, Harkema JR.  2015, Ozone-Induced Type 2 Immunity in Nasal Airways: Development and Lymphoid Cell Dependence in Mice. Am J Respir Cell Mol Biol. 2015 Jul 23. [Epub ahead of print] PMID: 26203683.
  5. Nault R, Fader KA, Zacharewski T.  2015, RNA-Seq versus oligonucleotide array assessment of dose-dependent TCDD-elicited hepatic gene expression in miceBMC Genomics. 2015 May 10;16:373. doi: 10.1186/s12864-015-1527-z. PMID: 25958198. PMCID: PMC4456707.
  6. Nault R, Colbry D, Brandenberger C, Harkema JR, Zacharewski TR. 2014, Development of a computational high-throughput tool for the quantitative examination of dose-dependent histological features. Toxicol Pathol. 2015 Apr;43(3):366-75. doi: 10.1177/0192623314544379. Epub 2014 Oct 1. PMID: 25274660. PMCID: PMC4382446.
  7. Nault R, Forgacs AL, Dere E, Zacharewski TR. 2013, Comparisons of differential gene expression elicited by TCDD, PCB126, βNF, or ICZ in mouse hepatoma Hepa1c1c7 cells and C57BL/6 mouse liver. Toxicol Lett. 2013 Oct 23;223(1):52-9. doi: 10.1016/j.toxlet.2013.08.013. Epub 2013 Aug 29. PMID: 23994337. PMCID: PMC4096832.
  8. Kopec AK, Boverhof DR, Nault R, Harkema JR, Tashiro C, Potter D, Sharratt B, Chittim B, Zacharewski TR.  2013, Toxicogenomic evaluation of long-term hepatic effects of TCDD in immature, ovariectomized C57BL/6 mice. Toxicol Sci. 2013 Oct;135(2):465-75. doi: 10.1093/toxsci/kft156. Epub 2013 Jul 17. PMID: 23864506. PMCID: PMC3807621.
  9. Nault R, Kim S, Zacharewski TR. Comparison of TCDD-elicited genome-wide hepatic gene expression in Sprague-Dawley rats and C57BL/6 mice.Toxicol Appl Pharmacol. 2013 Mar 1;267(2):184-91. doi: 10.1016/j.taap.2012.11.028. Epub 2012 Dec 11. PMID: 23238561

Mark Williams

  1. Chen F, Li A, Gao S, Hollern D, Williams M, Liu F, VanSickle EA, Andrechek E, Zhang C, Yang C, Luo R, Xiao H.  2014, Tip30 controls differentiation of murine mammary luminal progenitor to estrogen receptor-positive luminal cell through regulating FoxA1 expression.  Cell Death Dis. 2014 May 22;5:e1242. doi: 10.1038/cddis.2014.224. PMID: 24853420.  PMCID: PMC4047867.
  2. Gao S, Li A, Liu F, Chen F, Williams M, Zhang C, Kelley Z, Wu CL, Luo R, Xiao H. 2013, NCOA5 haploinsufficiency results in glucose intolerance and subsequent hepatocellular carcinoma. Cancer Cell. 2013 Dec 9;24(6):725-37. doi: 10.1016/j.ccr.2013.11.005. PMID: 24332041.  PMCID: PMC3891053.
  3. Williams M, Liu F, Su R, Rongcheng L, Xiao H.  2015, Dysregulation of NCOA5 expression alters cell cycle of hepatocellular carcinoma cells.  Presented at Biology of Cancer: Microenvironment, Metastasis & Therapeutics, Cold Spring Harbor.  

Joe Zagorksi

  1. Turley AE, Zagorski JW, Rockwell CE. 2015, The Nrf2 activator tBHQ inhibits T cell activation of primary human CD4 T cells.  Cytokine. 2015 Feb;71(2):289-95. doi: 10.1016/j.cyto.2014.11.006. Epub 2014 Dec 5. PMID: 25484350.  PMCID: PMC4297602.
  2. Zagorski JW, Turley AE, Dover HE, VanDenBerg KR, Compton JR, Rockwell CE. The Nrf2 activator, tBHQ, differentially affects early events following stimulation of Jurkat cells.Toxicol Sci. 2013 Nov;136(1):63-71. doi: 10.1093/toxsci/kft172. Epub 2013 Aug 14.

  3. Zagorski JW, Turley AL, Maser TP, Rockwell CE. (EB 2015) Determination of the Effects of Nrf2 upon the Early Events of Jurkat T Cell Activation by Use of CRISPR-CAS9 Mediated Mutation. The FASEB Journal.