Bill Zuercher, Ph.D., University of North Carolina
- University of North Carolina
Eshelman School of Pharmacy
Topic: Chemical probes for the historically understudied kinome
- Date: Friday, October 7
- Time: 9 to 10 a.m.
- Place: B448 Life Science Bldg
- Host: Dexheimer
- Abstract: Despite the approval of more than 30 small molecule kinase inhibitors for the treatment of human disease since the turn of the century, the kinome remains to be more fully elucidated. Indeed, over 80% of human kinases are poorly studied and have insufficiently understood roles in human (patho)biology. Access to high-quality chemical and biological enabling reagents is a critical step to enabling researchers to shift their attention towards such historically understudied proteins. In this presentation, we will present examples of our efforts to generate and make openly available chemical probe sets for kinases which have received scant attention to date. We will also describe our strategy to experimentally prioritize members of the historically understudied kinome.