Drug Discovery: Alan Smrcka, Ph.D.
- Topic: Small Molecule Manipulation of G Protein bg Subunit Signaling: Identification and Application
- Date: Friday, April 28th 2017
- Time: 9am
- Place: B448 Life Science Building
Our laboratory has identified a number of small molecules that bind to Gbg subunits and selectively modify signaling responses downstream of GPCRs that signal at least in part through Gbg. I will discuss the initial discovery and validation of prototype compounds and application of compounds that inhibit Gbg signaling in animal models of therapeutics, with a focus on inflammatory disease. I will also discuss our latest results using a Gbg activating compound to reveal novel mechanistic roles for Gai signaling in cell migration and adhesion. Finally I will discuss our progress on screening for novel chemical scaffolds for Gbg modulation that could become leads for pharmaceutical development.