Topic: Deconstructing cell behavior with subcellular optogenetics
Date: Wednesday, September 28th
Time: 12 to 1 p.m.
Place: B448 Life Science Bldg
Abstract: A number of molecules involved in cell migration have been identified but it is not clear how they interact dynamically to govern cell behaviors like migration. We have developed optogenetic approaches to perturb signaling protein activity and local plasma membrane tension in intact living cells. We have used these to identify how dynamic subcellular changes in signaling and membrane tension operate together to execute complex migratory responses.