Department of Obstetrics, Gynecology and Rreproductive Biology
Topic:SWI/SNF chromatin remodeling-PI3-Kinase pathway
crosstalk mechanisms in cancer
In non-pregnant female mammals of reproductive age, ovulation (the releasing of eggs from the ovaries) and menstruation (the shedding of the uterine lining) occurs each month. This repeated cellular turnover causes stress and inflammation, which puts females at risk for developing certain reproductive-tract cancers.
The goal of our research is to discover which genes and signaling pathways play a critical role in determining cellular homeostasis in the female reproductive system (particularly in ovarian cancer and associated benign disease) and how cells within the female reproductive tract cope with the iterative tissue repair processes and inflammation necessary for maintaining reproductive competence. We aim to provide a mechanistic understanding of how epigenetic or chromatin-regulated processes maintain cellular homeostasis and prevent tumorigenesis in the female reproductive tract in response to environmental or intracellular stress and the ensuing activation of cellular signaling.