Assay Development and Drug Repurposing Core (ADDRC)

Assay Development and Drug Repurposing Core (ADDRC)

The MSU Assay Development and Drug Repurposing Core (ADDRC) facility located in the Department of Pharmacology and Toxicology was created to assist MSU researchers with bridging the drug discovery gap that often exists between their basic research and preclinical drug development. The primary focus of the ADDRC is to aid investigators in developing HTS-compatible assays, to generate preliminary data for grants and funding opportunities, and to screen biological targets with the goal of providing chemical probes to further interrogate a particular biological process or potential leads for drug development.

Equipment and Resources

The ADDRC will be equipped with compound screening libraries on the order of 10,000 compounds, including about a thousand FDA-approved drugs with the aim of identifying new indications for existing clinical compounds or drug repurposing. The facility will possess a variety of 96/384-tip liquid handlers, bulk liquid dispensers, and multi-format plate readers with the capacity to address multiple assay methodologies. Faculty will also have access to a microscopy-based high-throughput instrument for automated high content imaging and analysis of fixed or live cells. And most recently, the ADDRC facility has acquired a functional drug screening system (FDSS) microCell, a state-of-the-art imaging plate reader for kinetic cell-based assay development and HTS.

While the ADDRC is located in the Life Sciences Building on campus, it is a shared resource established to serve faculty across the MSU campus. In addition, the involvement of undergraduate/graduate students and postdoctoral scientists from investigators’ laboratories, who are interested in learning more about drug discovery and the principles of high-throughput screening, is also strongly encouraged.

MSU Assay Development and Drug Repurposing Core - Recharge Rates

Tom Dexheimer
ADDRC Manager
B411, Life Sciences Building
Lab: (517) 884-4998
Cell: (301) 335-3137
dexheim1@msu.edu