Watts Lab Receives NIH Grant

  • Aug 1, 2014

The National Institute of Health / National Heart, Lung and Blood Institute has awarded a grant to Michigan State University ( P.I. Dr. Stephanie Watts, Department of Pharmacology & Toxicology ) for the project “Chemerin as a Link Between Obesity and Blood Pressure” [excerpt from abstract]

“Perivascular adipose tissue (PVAT) is fat perfectly situated to influence vascular tone. In this proposal, we provide substantial evidence for the expression and novel contractile function of a peptide that is typically discussed as being produced within visceral white adipose tissue (WAT) and the liver, but never associated with PVAT. Chemerin (tazarotene induced gene, TIG2; RARRES2) is a biomarker for adiposity. Circulating chemerin levels associate strongly with BMI, and chemerin levels are reduced with reduction of weight and fat.”

Read more about the grant.