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Carolina de Aguiar Ferreira

Carolina de Aguiar Ferreira
Assistant Professor
IQ (775 Woodlot Dr) Room 4113
deaguia1@msu.edu

EDUCATION

  • PharmD (UFMG, Brazil)
  • MSc in Material and Nuclear Science (CDTN, Brazil)
  • PhD in Biomedical Engineering (University of Wisconsin-Madison)

 

BIOGRAPHY & CURRENT RESEARCH

Dr. Carolina de Aguiar Ferreira has received a PharmD, an M.Sc. in Material and Nuclear Sciences, and a Ph.D. degree in Biomedical Engineering, without losing focus on what made her interested in research in the first place: making people’s lives better. Dr. de Aguiar Ferreira has been working with biological applications of radiation for the past 15 years. She has published close to 50 peer-reviewed articles in high-impact journals and won three Young Investigator Awards from the Society of Nuclear Medicine and Molecular Imaging (SNMMI), and made the SNMMI’s “Ones to Watch” list in 2021. MIRA laboratory, led by Dr. Ferreira, focus on the use of radiation as a solution for healthcare problems. We utilize radiolabeled compounds for non-invasive detection of diseases and the immune system as well as for cancer therapy and modulation of the immune system.

CURRENT PROJECTS

We currently focus on three major areas. (i) Non-invasive Detection of Diseases: through molecular imaging (PET/CT, SPECT/CT, PET/MR), we aim at early detection, patient selection and monitoring of diseases. Our latest publication reported non-invasive imaging of immune-related adverse events with a peptide that targets granzyme B. (ii) Radiopharmaceutical Therapy: we utilize moieties radiolabeled with beta or alpha emitters to achieve curative cancer treatment. We also investigated its potential synergistic effects when combined with other therapeutic modalities such as immune checkpoint inhibitors, DNA damage response inhibitors, immune-modulatory agents, etc (iii) Radiation and the immune system: we aim at understanding the effects of ionizing radiation on the immune system and investigate how we can harness radiation immunomodulatory effects to develop new combinatory treatment regimens.

AWARDS & ACHIEVEMENTS

  • June – 2022 Project submitted to the 2021 SNMMI Annual Meeting selected for a press release June – 2022
  • Nominated for Young Investigator Award in the Center for Molecular Imaging Innovation and Translation (CMIIT) Young Investigator Award Symposium at 2022 SNMMI Annual Meeting December – 2021 Carolina was featured in a Molecular Pharmaceutics article describing her experience as a researcher developing the next generation of radioactive theranostics
  • July – 2021 Selected as “One´s to Watch” from SNMMI
  • June – 2021 Project submitted to the 2021 SNMMI Annual Meeting selected for a press release
  • June – 2021 Nominated for Young Investigator Award in the Center for Molecular Imaging Innovation and Translation (CMIIT) Young Investigator Award Symposium at 2021 SNMMI Annual Meeting
  • June - 2020 1st Place in the Center for Molecular Imaging Innovation and Translation (CMIIT) Young Investigator Award Symposium at 2020 SNMMI Annual Meeting June - 2019 2nd Place in the Radiopharmaceutical Sciences (RPSC) Young Investigator Award Symposium at 2019 SNMMI  Annual Meeting
  • May - 2019 Student Research Travel Grant: University of Wisconsin-Madison Student Research Grants Competition Travel Award
  • April - 2019 Travel Award to attend the 2019 SNMMI Annual Meeting
  • June - 2018 3rd Place in the Center for Molecular Imaging Innovation and Translation (CMIIT) Young Investigator Award Symposium at the 2018 SNM
  • Annual Meeting April - 2018 Travel Award to attend the 2018 SNMMI Annual Meeting
  • Aug 2015 – Jul 2019 Science without Borders Program – Full Scholarship for PhD studies abroad
  • Apr 2012 – Mar 2014 First Place – M.Sc. Proposal - Full Master´s degree scholarship

PUBLICATIONS

  • Ferreira CA, Heidari P, Ataeinia B, Sinevici N, Granito A, Kumar HM, Wehrenberg-Klee E, Mahmood U. Immune Checkpoint Inhibitor-Mediated Cancer Theranostics with Radiolabeled Anti-Granzyme B Peptide. Pharmaceutics. 2022; 14(7):1460. https://doi.org/10.3390/pharmaceutics14071460
  • Ferreira CA, Pedram Heidari, Nicoleta Sinevici, Meghan E. Sise, Robert B. Colvin, Eric Wehrenberg-Klee, Umar Mahmood. Non-invasive Detection of Immunotherapy-induced Adverse Events. Clinical Cancer Research, July 2021. DOI: 10.1158/1078-0432.CCR-20-4641
  • Ferreira CA, Goel S, Ehlerding EB, Rosenkrans ZT, Jiang D, Sun T, Aluicio-Sarduy E, Engle JW, Ni D, Cai W. Ultrasmall Porous Silica Nanoparticles with Enhanced Pharmacokinetics for cancer Theranostics. Nano Letters, May 2021. DOI: 10.1021/acs.nanolett.1c00895
  • Potluri, HK, Ferreira CA, Grudzinski J, Massey C, Aluicio-Sarduy E, Engle JW, Kwon O, Marsh IR, Bednarz BP, Hernandez R, Weichert JP, McNeel DG. Antitumor efficacy of 90Y-NM600 targeted radionuclide therapy and PD- 1 blockade is limited by regulatory T cells in murine prostate tumors. Journal for Immunotherapy of Cancer, August 2022. DOI: 10.1136/jitc-2022-005060 
  • Ferreira CA, Kang L, Li C, Kamkaew A, Barret KE, Aluicio-Sarduy, Yang Y, Engle JW, Jiang D, Cai W. ImmunoPET of the differential expression of CD146 in breast cancer. American Journal of Cancer Research, April 2021. PMID: 33948375