Anne Dorrance, Ph.D.
- Cardiovascular Staff, Drug Discovery and Receptor Faculty, Online Faculty
Pharmacology & Toxicology
B340 Life Sciences
1355 Bogue Street
East Lansing, MI 48824
Fields of Interest: The Dorrance Lab is dedicated to identifying novel mechanisms to improve the outcome of acute ischemic stroke.
- 1993 - B.Sc., Pharmacology, University of Edinburgh, Scotland
- 1997 - Ph.D., Medicine and Therapeutics, University of Glasgow, Scotland
- 1997-1999 - Postdoctoral Fellow, The University of Michigan
- 2000 - Postdoctoral Fellow, Medical College of Georgia
- 2001-2007 - Assistant Professor, Physiology, Medical College of Georgia
- 2007-present - Associate Professor, Pharmacology & Toxicology, Michigan State University
The brain is exquisitely sensitive to changes in blood flow because even small reductions in flow can cause neuronal injury. In the most extreme situation, when blood flow completely stops, a stroke occurs. Milder reductions in blood flow can result in the development of cognitive impairments that lead to dementia development. In the Dorrance lab, we study how cerebral arteries regulate blood flow and how conditions like obesity and hypertension impair this process. By doing this we may identify treatments to slow or prevent the development of dementia and improve the outcome of a stroke.
Current Projects in the Dorrance Lab
Endothelial Mineralocorticoid Receptors and Cognitive Function
The adrenal steroid aldosterone binds to, and activates the mineralocorticoid receptor (MR). We discovered that MR activation has detrimental effects on cerebral artery structure, but at that time we were unable to identify the specific cell type involved in the process. This new project utilizes endothelial cell specific MR knockout mice to define cell specific effects of MR activation. We are working to understand how activation of the MR in the endothelium affects the cerebral arteries blood vessels contract and dilate to regulate blood flow. We are also investigating how changes in artery structure and function impact learning and memory.
Obesity Associated Dementia Development
Obesity has reached epidemic proportions in the U.S. and obesity rates are increasing worldwide. Obese and overweight patients are more likely to develop dementia. This appears to be because obesity reduces cerebral blood flow, if we can understand how this happens it may be possible to identify treatments to prevent the development of dementia in the obese population. This project combines in vivo and in vitro studies with MRI measurements of blood flow, behavioral testing and gene silencing techniques in multiple models of obesity.
Clinically the treatment of stroke has improved dramatically in the last decade. The reduction in the death rate from stroke has led to the identification of a new problem; at least one third of all stroke survivors develop dementia in the years following their stroke. At present, we do not fully understand what happens to cerebral arteries after a stroke, it is possible that artery function is impaired long term post-stroke and that this can drive cognitive decline. We are currently developing a model of post-stroke dementia that will allow us to assess the efficacy of candidate drugs for post-stroke dementia.
Committees & Activities (Since 2015)
- Editorial board of Hypertension
- Editorial board American Journal of Physiology; Heart and Circulatory Physiology
- Editorial board of Clinical Sciences
National and International Grant Review Service
- 2015: Grant review for the Marsden Fund, New Zealand
- 2015-Present: Ad hoc member of the F03A Neurodevelopment, Synaptic Plasticity and Neurodegeneration study section
- 2017: Grant review for the Oregon Alzheimer’s Disease Center
- 2017: Grant review for the Medical Research Council, United Kingdom
- 2018: Grant review for the Health Research Council of New Zealand
National and International Meeting Organization and Abstract Review Service
- 2015: Co-organizer of an APS sponsored symposium at EB on the effects of hypertension on the cerebral circulation
- 2015: International Stroke Conference Program Committee – Chair of the Experimental Mechanisms and Models Section
National-Professional Society Service
- 2017-Present: Member of the American Physiological Society Cardiovascular section program Committee
- 2017-Present: Cardiovascular Section Representative to the American Physiological Society Joint Program Committee (EB2018)
- 2007-Present: Department of Pharmacology and Toxicology Graduate Program Committee - Michigan State University (Chair and Graduate Program Director since 2010)
- 2013-2016: Department of Pharmacology and Toxicology Search Faculty Advisory Committee
- 2013-2017: Department of Pharmacology and Toxicology Alumni Relations and Development Committee
Local-College and University Service
- 2011-Present: Biomolecular Science Umbrella Program Executive Committee
- 2015: College of Osteopathic Medicine, College Advisory Committee (Chair 2012-2014)
- 2015: University Fellowship Review Committee - Graduate School
- 2015-2017: University Fellowship Coordinator and Review Committee Chair - Graduate School
- 2015-Present: College of Osteopathic Medicine Bylaws Committee
Local Community Outreach
- 2014-Present: Organizer of the Marble Elementary Science Night
- 2016-Present: MacDonald Middle School Science Fair Judge
- 2017: Advisor for the Marble Elementary 4/5 Grade STEM Club
Representative Publications (Since 2015)
A.M. Dorrance, G. Fink. Effects of Stroke on the Autonomic Nervous System. Compr Physiol. 5(3):1241-63, 2015
P.W. Pires, W.F. Jackson, A.M. Dorrance, Regulation of myogenic tone and structure of parenchymal arterioles by hypertension and the mineralocorticoid receptor. Am J Physiol Heart Circ Physiol, 309(1): H127-136, 2015.
J.M. Diaz-Otero, H. Garver, G.D. Fink, W. F. Jackson, A.M. Dorrance, Aging is associated with changes to the biomechanical properties of the posterior cerebral artery and parenchymal arterioles. Am J Physiol Heart Circ Physiol, 310(3):H365-75, 2016.
A.A. Phillips, N. Matin, B. Frias, M. M. Zheng, M. Jai, C. West, A.M. Dorrance, I. Laher, A.V. Krassioukov, Rigid and remodelled: Cerebrovascular structure and function after experimental high-thoracic spinal cord transection. J Physiol, 594(6):1677-88, 2016.
N. Matin, C. Fisher, W.F. Jackson, A.M. Dorrance, Bilateral Common Carotid Artery Stenosis in Normotensive Rats Impairs Endothelial Dependent Dilation Of Parenchymal Arterioles. Am J Physiol Heart Circ Physiol, 310(3): H365-75, 2016
N. Matin, P.W. Pires, H. Garver, W.F. Jackson, A.M. Dorrance, DOCA-Salt Hypertension Impairs Artery Function in Rat Middle Cerebral Artery and Parenchymal Arterioles. Microcirculation, 23(7): 571-579, 2016.
J.M. Diaz-Otero, C. Fisher, K. Downs, M.E. Moss, I.Z. Jaffe, W.F. Jackson, A.M. Dorrance. The Endothelial Mineralocorticoid Receptor Mediates Parenchymal Arteriole and Posterior Cerebral Artery Remodeling during Angiotensin II-induced Hypertension. Hypertension, 70(6):1113-1121, 2017
A.A. Phillips, N Matin, M. Jia, J.W. Squair, A. Monga, M.M.Z. Zheng, R. Sachdeva, A. Yung, S. Hocolaski, S.L. Elliott, P. Kozlowski, A. Dorrance, I. Laher, P. Ainslie, A.V. Krassioukov. Transient hypertension after spinal cord injury leads to cerebrovascular endothelial dysfunction and fibrosis. J Neurotrauma, 35(3): 573-58, 2018.
N. Matin, C. Fisher, W.F. Jackson, J.M.Diaz-Otero, A.M. Dorrance, Carotid Artery Stenosis In Hypertensive Rats Impairs Dilatory Pathways In Parenchymal. Am J Physiol Heart Circ Physiol, 314(1): H122-H130, 2018.
P.W. Pires and A.M. Dorrance. The Effects of Hypertension on Cerebral Artery Structure and Function, and Cerebral Blood Flow. In, Hypertension and the Brain as an End-Organ Target, Hélène Girouard (Eds) – Springer (2016).
A.M. Dorrance. The effects of hypertension and stroke on the cerebral vasculature. In, Hypertension and Stroke: Pathophysiology and Management, Second Edition, Venkatesh Aiyagari and Philip B. Gorelick (Eds) – Springer (2016)