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Jack Harkema, DVM, PhD, DACVP, ATSF

University Distinguished Professor, College of Veterinary Medicine


Albert C. and Lois E. Dehn Endowed Chair in Veterinary Medicine (Pathobiology and Diagnostic Investigation)

Director of the Laboratory for Environmental & Toxicologic Pathology and the Mobile Air Research Laboratories (AirCARE 1 and 2) at Michigan State University

Pathobiology and Diagnostic Investigation

Dr. Jack Harkema
Food Safety and Toxicology Building
1129 Farm Lane, Room 212 
Michigan State University
East Lansing, MI 48824

Email: harkemaj@msu.edu

Phone: (517) 353-8627 | Location:  212 Food Safety & Toxicology

Fields of Interest:

To understand the pathologic basis of health effects caused by environmental and occupational air pollutants Using laboratory animal models of respiratory, cardiovascular, autoimmune and metabolic diseases to explore how chronic diseases effect susceptibility to toxicity caused by inhaled toxicants (ozone, particulate matter and silica dust) With the overall goal to experimentally elucidate cellular, molecular or biochemical targets for interventions to prevent (or treat) adverse effects caused by air pollution.

    • BS, Calvin College, 1975
    • MS, Michigan State University, 1977
    • DVM, Michigan State University, 1980
    • Postdoctoral Fellowship, Lovelace Respiratory Research Institute, 1980-82
    • Residency in Veterinary Anatomic Pathology, University of California, Davis, 1982-85
    • PhD, University of California, 1985
    • Diplomate, American College of Veterinary Pathologists, 1988
    • Fellow, American Thoracic Society, 2018


    • Role of group 2 innate lymphoid cells (ILC2s) in air pollutant-induced, allergen-independent asthma and rhinitis
    • Mechanisms of dietary lipid prevention/treatment for silica-induced autoimmunity
    • Airway and systemic inflammatory/immune responses to short-and long-term exposures to ambient air pollutants individually or as mixtures


    • General pathology
    • Comparative pathology
    • Integrated toxicology
    • Respiratory pathobiology
    • Inhalation toxicology


    • Standing Member, US EPA Clean Air Science Advisory Committee
    • Past Chair, Environmental, Occupational and Population Health Assembly of the American Thoracic Society
    • Past Member, Executive Council of the Society of Toxicologic Pathology


    • Diplomat of the American College of Veterinary Pathologists