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William F. Jackson, Ph.D.

Professor, Pharmacology & Toxicology

Dr. William F. Jackson
B429 Life Science Building
1355 Bogue Street
East Lansing, MI 48823

Email: jacks783@msu.edu

Phone: (517) 353-5476 | Fax: (517) 353-8915 | Location:  B429 Life Sciences

Fields of Interest: Examination of how arterioles in the microcirculation sense their environment; the role of smooth muscle and endothelial cell ion channels in the regulation of calcium signaling; vascular cell signaling related to vasodilation and vasoconstriction.

    • 1970-74 - B.S., Zoology, Michigan State University
    • 1974-76 - M.S., Physiology, Michigan State University
    • 1976-79 - Ph.D., Physiology, Michigan State University
    • 1977-80 - MS., Applied Math, Michigan State University
    • 1980-83 - Postdoctoral Fellow, University of Virginia, Physiology

    Academic Positions

    • 1983-89 - Assistant Professor, Physiology & Endocrinology- Medical College of Georgia
    • 1989 - Associate Professor, Physiology & Endocrinology- Medical College of Georgia
    • 1989-94 - Associate Professor, Biological Sciences- Western Michigan University
    • 1994-2005 - Professor, Biological Sciences- Western Michigan University
    • 2005-Present - Professor, Pharmacology and Toxicology - and Director,Online Professional Science Masters in - Integrative Pharmacology program- Michigan State University
    • 2011-2013- Acting Chair, Pharmacology and Toxicology - Michigan State University

    Research Synopsis

    Ongoing studies in Dr. Jackson’s laboratory seek to understand how arterioles in the microcirculation sense their environment and how changes in the environment alter the contractile function of vascular muscle cells in the walls of these microvessels to lead to changes in blood flow and blood pressure. Using techniques such as intravital videomicroscopy, single cell contraction, immunocytochemistry, single cell quantitative RT-PCR, fluorescence microscopy, calcium imaging, patch clamp recording, pressure myography and conventional microelectrode methods, the Jackson lab seeks to understand the role played by smooth muscle and endothelial cell ion channels in the regulation of calcium signaling and vascular smooth muscle tone in arterioles related to the local regulation of blood flow in the microcirculation, and the impact of aging and disease states, such as hypertension and obesity, on these processes.

    Selected Awards

    • 2014 - Fellow of the American Heart Association
    • 1998 - WMU, Distinguished Faculty Scholar Award
    • 1995 - National Institutes of Health, National Research Service Award, Senior Postdoctoral Fellowship
    • 1987 - Medical College of Georgia, School of Medicine, Outstanding Young Faculty Award, Basic Sciences
    • 1984-1987 - National Institutes of Health, New Investigator Research Award
    • 1981-1983 - National Institutes of Health, National Research Service Award, Individual Postdoctoral Fellowship

    Selected Achievements since 2001

    • 2008-2011 - President-elect, President, and past-President, The Microcirculatory Society, Inc.
    • 2007-2009 - Circulation Research, Editorial Board
    • 2004-2009 - Editor-in-Chief, Microcirculation
    • 2001-2015 - American Journal of Physiology, Heart and Circulatory Physiology, Editorial Board
    • 2001-2015 - Journal of Investigative Surgery, Editorial Board
    • 1999-2004 - Associate Editor, Microcirculation
    • 1995-2015 - Journal of Vascular Research, Editorial Board
    • 2015-2018 - Microcirculatory Society, Inc. Awards Committee
    • 2014-2016 - American Physiological Society, Cardiovascular Section Steering Committee and Com. on Com. Rep. ASPET – Graduate Recruitment and Education Committee
    • 2009-2011 - National Directors of Graduate Studies Organizing Committee (Chair) and Programming Committee
    • 2003-2007 - National Institutes of Health, Charter member Vascular Cell and Molecular Biology Study Section

    Full list of publications at MSU Scholars

    • Jackson, WF. Endothelial cell ion channel expression and function in arterioles and resistance arteries. In Vasuclar Ions Channels in Health and Disease, Edited by Levitan, I and Dopico, AM, Springer, in Press, 2015.
    • Ayala-Lopez, N, Jackson WF, Burnett, R, Wilson, JN, Thompson JM, Watts SW. Organic Cation Transporter 3 Contributes to Norepinephrine Uptake into Perivascular Adipose Tissue. Am J Physiol Heart Circ Physiol., in Press, 2015.
    • Pires, PW, Jackson WF, Dorrance AM. Regulation of myogenic tone and structure of parenchymal arterioles by hypertension and the mineralocorticoid receptor. Am J Physiol Heart Circ Physiol. 309(1):H127-H136, 2015. PMID: 25910805; PMCID: PMC4491521
    • Robinson NE, Williams KJ, Stack A, Jackson WF, Derksen FJ. Exercise-induced pulmonary haemorrhage: A progressive disease affecting performance? Equine Vet J. 2015 Feb 24. doi: 10.1111/evj.12412. [Epub ahead of print] PMID: 25712624.
    • Stack A., Derksen F.J., William K.J., Robinson, N.E., and Jackson W.F. Lung Region and Racing Affect Mechanical Properties of Equine Pulmonary Microvasculature. J Appl Physiol. 2014 Aug 15;117(4):370-6. doi: 10.1152/japplphysiol.00314.2014. Epub 2014 Jun 12.PMID: 24925981
    • Jackson WF. Arachidonate-induced dilation of retinal arterioles: more than meets the eye. Invest Ophthalmol Vis Sci. 2014 May 2;55(5). pii: 2903. doi: 10.1167/iovs.14-14510. PMID: 24793224
    • Hayoz, S., Bradley, V. Boerman, E.M., Nourian, Z., Segal, S.S. and Jackson W.F. Aging increases the size and spontaneous transient outward current amplitude of smooth muscle cells from murine superior epigastric arteries. Am J Physiol Heart Circ Physiol. 2014 Apr 4. [Epub ahead of print], PMID: 24705555.
    • Tykocki NR, Jackson WF, Watts SW. Reverse-mode Na+/Ca2+ exchange is an important mediator of venous contraction. Pharmacol Res. 2012 Dec;66(6):544-54. doi: 10.1016/j.phrs.2012.08.004. Epub 2012 Sep 10. PubMed PMID: 22974823; PubMed Central PMCID: PMC3502721.
    • Tykocki NR, Thompson JM, Jackson WF, Watts SW. Ryanodine receptors are uncoupled from contraction in rat vena cava. Cell Calcium. 2013 Feb;53(2):112-9. doi: 10.1016/j.ceca.2012.10.006. Epub 2012 Nov 22. PubMed PMID: 23177664.
    • Westcott EB, Goodwin EL, Segal SS, Jackson WF. Function and expression of ryanodine receptors and inositol 1,4,5-trisphosphate receptors in smooth muscle cells of murine feed arteries and arterioles. J Physiol. 2012 Apr 15;590(Pt 8):1849-69. doi: 10.1113/jphysiol.2011.222083. Epub 2012 Feb 13. PubMed PMID: 22331418; PubMed Central PMCID: PMC3573308.
    • Westcott EB, Jackson WF. Heterogeneous function of ryanodine receptors, but not IP3 receptors, in hamster cremaster muscle feed arteries and arterioles. Am J Physiol Heart Circ Physiol. 2011 May;300(5):H1616-30. doi: 10.1152/ajpheart.00728.2010. Epub 2011 Feb 25. PubMed PMID: 21357503; PubMed Central PMCID: PMC3094085.
    • Jackson WF. Standing out in a crowd: knockout of ApoE increases the potency of endothelium-dependent vasodilators in mesenteric arteries. Cardiovasc Res. 2011 Nov 1;92(2):183-4. doi: 10.1093/cvr/cvr253. Epub 2011 Sep 21. PubMed PMID: 21937581.