Jane F. Maddox, D.V.M., Ph.D.
Pharmacology & Toxicology
Director of Online Programs
Dr. Jane F. Maddox
1355 Bogue Street
B305 Life Sciences
East Lansing, MI 48823
Fields of Interest: Exacerbation of acetaminophen-induced injury by a small, non-injurious dose of lipopolysaccharide (LPS, derived from E. coli).
- 1978-82 - B.S., Veterinary Science, Michigan State University
- 1980-84 - D.V.M., Veterinary Medicine, Michigan State University
- 1984-86 - Private Veterinary Practice, large and small animal
- 1987-92 - Ph.D., Pathobiology, The Pennsylvania State University
- 1992-95 - Postdoctoral Fellow, Brigham and Women’s Hospital, Harvard University
- 1995-97 - Instructor, Brigham and Women’s Hospital, Harvard University
- 1997-00 - Research Associate, The Pennsylvania State University
- 2000-present - Assistant Professor, Pharmacology & Toxicology, Michigan State University
My research has evolved from an inflammation/arachidonic acid metabolites/antioxidant focus to inflammation/drug-related liver injury. The focus of recent studies is the exacerbation of acetaminophen-induced injury by a small, non-injurious dose of lipopolysaccharide (LPS, derived from E. coli). The inflammatory response induced by LPS appears to potentiate the toxicity of acetaminophen and we are examining the mechanisms leading to this injury in mouse models at the cellular and molecular levels. These studies may help determine the causes of drug-induced idiosyncratic reactions in people.
Selected Achievements since 2001
- Arthritis Investigator Award, Arthritis Foundation – Role of lipoxins in endothelial cell/leukocyte-mediated chronic inflammation during selenium deficiency (Hulda Irene Duggan Award, 8/98-7/04).
- R03: NIH (NIAAA, NCCAM and ODS): SAMe Inhibits Inflammatory-mediated Increase in Toxicity; Principal Investigator, 2002-2004.
- Online Education Committee, 2009-present
- Veterinary Pharmacology II
- Safety Pharmacology (online)
- Cellular and Molecular Toxicology (online)
- CHM Problem-Based-Learning domains
- Online Master’s in Pharmacology and Toxicology program
- Sparkenbaugh EM, Saini Y, Greenwood KK, LaPres JJ, Luyendyk JP, Copple BL, Maddox JF, Ganey PE, Roth RA. The role of hypoxia-inducible factor-1α in acetaminophen hepatotoxicity. J Pharmacol Exp Ther. 2011 Aug;338(2):492-502. doi: 10.1124/jpet.111.180521. Epub 2011 May 16. PubMed PMID: 21576378; PubMed Central PMCID: PMC3141908.
- Liguori MJ, Ditewig AC, Maddox JF, Luyendyk JP, Lehman-McKeeman LD, Nelson DM, Bhaskaran VM, Waring JF, Ganey PE, Roth RA, Blomme EA. Comparison of TNFα to Lipopolysaccharide as an Inflammagen to Characterize the Idiosyncratic Hepatotoxicity Potential of Drugs: Trovafloxacin as an Example. Int J Mol Sci. 2010 Nov 18;11(11):4697-714. doi: 10.3390/ijms11114697. PubMed PMID: 21151465; PubMed Central PMCID: PMC3000109.
- Poissant J, Hogg JT, Davis CS, Miller JM, Maddox JF, Coltman DW. Genetic linkage map of a wild genome: genomic structure, recombination and sexual dimorphism in bighorn sheep. BMC Genomics. 2010 Sep 28;11:524. doi: 10.1186/1471-2164-11-524. PubMed PMID: 20920197; PubMed Central PMCID: PMC3091677.
- Aibo DI, Birmingham NP, Lewandowski R, Maddox JF, Roth RA, Ganey PE, Wagner JG, Harkema JR. Acute exposure to ozone exacerbates acetaminophen-induced liver injury in mice. Toxicol Sci. 2010 May;115(1):267-85. doi: 10.1093/toxsci/kfq034. Epub 2010 Feb 1. PubMed PMID: 20123758; PubMed Central PMCID: PMC2855356.