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Sangbum Park, Ph.D.

Assistant Professor, Department of Pediatrics and Human Development

Institute for Quantitative Health Sciences and Engineering
IQ Building, Room 3317
775 Woodlot Dr.
East Lansing, MI 48824
 
Email: spark@msu.edu | Phone: (517) 353-2479
 
Fields of Interest: I am interested in understanding the principles of adult tissue regeneration, especially wound repair in live mammals by using in vivo imaging system with the multiphoton microscope.
 
  • 2006: B.S. Animal Biotechnology, Seoul National University

  • 2012: Ph.D. Stem Cell Biology, Seoul National University

  • 2013 – 2018: Postdoctoral fellow, Yale University

  • 2018 – 2019: Associate Research Scientist, Yale University

  • 2020 – present: Assistant Professor, Michigan State University

Regeneration is essential for multicellular life. Many of our adult tissues, such as skin, blood and intestine, undergo constant regeneration to support homeostasis as well as repair injuries. Regeneration is a complex process that requires the participation of multiple cell types, including tissue-resident stem cells. Impaired stem cell function is known to severely impact tissue recovery. However, it remains unclear 1) how other coexisting cells in the tissue, known as the niche, coordinate with stem cells during the repair process and 2) whether interactions between stem and niche cells cause functional behavioral changes in the stem cell population. The challenge in addressing these questions has been an inability to follow the behaviors of different cell types at the same time in vivo and identify functional interactions between stem cells and the niche that regulate stem cell behaviors. Skin is an ideal system to study cellular behaviors of tissue repair because of its accessibility and well-characterized stem cell and niche populations.

In the Park lab, our long-term goal is to discover fundamental principles that underlie skin regeneration in a live animal. To achieve this goal, we utilize in vivo imaging with multiphoton laser microscopy and genetic mouse models to visualize and manipulate specific cell types within the skin of live mice. Our research is highly innovative because of our unique ability to study mammalian skin cells in a live unperturbed animal allow us to answer questions in biology that have been out of reach due to technical limitations. The research we are proposing will not only provide unprecedented insight into the cell biology and molecular mechanisms of tissue regeneration, but will also shed light on disease pathology and potential treatment strategies.

  • International Society for Stem Cell Research (ISSCR) Merit Award, 2019

  • International Investigative Dermatology (IID) Travel Fellowship Award, 2018

  • New York Stem Cell Foundation-Druckenmiller Fellowship, 2017

  • Poster prize. New York City Skin Club, 2016

  • Best Poster in the Postdoc. Yale Department of Genetics Retreat, 2015

  • Best Oral Abstract. 8th Yale Fibrosis Symposium, 2015

  • State of Connecticut Regenerative Medicine Research Fund seed grant award, 2015

  • James Hudson Brown – Alexander Brown Coxe Postdoctoral Fellowship, 2014

Most recent 5 Publications

  1. Brown S, Pineda CM, Xin T, Boucher JD, Suozzi KC, Park S, Matte-Martone C, Gonzalez DG, Rytlewski JA, Beronja S, Greco V. Correction of aberrant growth preserves tissue homeostasis. Nature. 2017 Aug 2; 548(7667):334-337.
  2. Park S, Gonzalez DG, Guirao B, Boucher JD, Cockburn K, Marsh ED, Mesa KR, Brown S, Rompolas P, Haberman AM, Bellaïche Y, Greco V. Tissue-scale coordination of cellular behavior promotes epidermal wound repair in live mice. Nat Cell Biol. 2017 Mar 1;19(2):155-163.
  3. Park S, Greco V, Cockburn K. Live imaging of stem cells: answering old questions and raising new ones. Curr Opin Cell Biol. 2016 Jul 27;43:30-37.
  4. Rompolas P, Mesa KR, Kawaguchi K, Park S, Gonzalez D, Brown S, Boucher J, Klein AM, Greco V. Spatiotemporal coordination of stem cell commitment during epidermal homeostasis. Science. 2016 Jun 17;352(6292):1471-4.
  5. Pineda CM*, Park S*, Mesa KR, Wolfel M, Gonzalez DG, Haberman AM, Rompolas P, Greco V. Intravital imaging of hair follicle regeneration in the mouse. Nat Protoc. 2015 Jul;10(7):1116-30. (* equal contributions)