Kin Sing Stephen Lee, Ph.D.
Pharmacology & Toxicology
Dr. Kin Sing Stephen Lee
B330A Life Sciences
1355 Bogue Street
East Lansing, MI 48824
Fields of Interest: Our research is focused on investigating the molecular mechanisms on how dietary lipids affect human health and human responses to environmental toxicants.
- 2003- Hong Kong University of Science and Technology
- 2010- Ph.D., Michigan State University
- 2010-2014- Post-doctoral Scholar, University of California at Davis
- 2014-2016- Project Scientist, University of California at Davis
- 2017- Assistant Professor, Pharmacology and Toxicology, Michigan State University
The overall theme of my research program is to study the interactions between dietary lipids, environmental chemicals and human health in molecular level. Our lab is particularly interested in studying the molecular mechanism on how the omega-3 (DHA, EPA, Fish oil, etc) to omega-6 (Arachidonic acid, Soybean oil, etc) ratio in our diet affects human diseases. Studies show that the metabolites from omega-3 and omega-6 lipids are biologically active and could account for some of the physiological effects induced by dietary lipids. Interestingly, the omega-3 and omega-6 epoxides, which are the major metabolites of the lipids, play a critical role in inflammation, blood pressure regulation, organ protection, wound healing, cancer and pain perception. However, the underlying mechanism on how these epoxides initiate the signaling pathway remains unknown.
Our lab focuses on designing new chemical probes and using the state-of-the-art instrumentation to solve the biological problems. The current research goal is to design and synthesize the mimics of omega-3 and omega-6 fatty acid epoxides. The selected mimics will be used to study the molecular mechanism on how fatty acid epoxides affect human health. Recently, our lab using the selected mimic to identify the receptor of the fatty acid epoxide. In addition, the structure of the selected mimics will be further optimized to improve their drug-likeness and could be a potential drug candidate to treat diseases. The ultimate goal of my research program is to improve human health through understanding the mechanism of the biological effects induced by dietary lipids.
- Post-Doctoral fellow of NIH T32 Training Program in Basic & Translation and Cardiovascular Science, 2014
- Awardee of K99/R00 NIH Pathway to Independence Award, 2015-present
National & International Society Committees
- American Chemical Society, 2003-
Wang W, Yang J, Nimiya Y, Lee KSS, Sanidad K, Qi W, Sukamtoh E, Park Y, Liu Z, Zhang G. ω-3 polyunsaturated fatty acids and their cytochrome P450-derived metabolites suppress colorectal tumor development in mice. J. Nutr. Biochem. 2017, 48, 29.
Rand AA, Barnych B, Morisseau C, Cajka T, Lee KSS, Panigraphy D, Hammock BD. Cyclooxygenase-derived proangiogenic metabolites of epoxyeicosatrienoic acids. Proc. Natl. Acad. Sci. U.S.A. 2017, 114, 4370.
Lee KS, Henriksen NM, Ng CJ, Yang J, Jia W, Morisseau C, Andaya A, Gilson MK,Hammock BD. Probing the orientation of inhibitor and epoxy-eicosatrienoic acidbinding in the active site of soluble epoxide hydrolase. Arch. Biochem. Biophys. 2017, 613, 1.
Supp D, Hahn J, McFarland KL, Combs KA, Lee KSS, Inceoglu B, Wan D, Boyce ST, Hammock BD. Soluble epoxide hydrolase inhibition and epoxyeicosatrienoic acid treatment improve vascularization of engineered skin substitutes Plast. Reconstr. Surg. Glob. Open 2016, 4, e1151.
Wagner K, Lee KS, Yang J, Hammock BD. Epoxy fatty acids mediate analgesia inmurine diabetic neuropathy. Eur. J. Pain 2016, in press