Nathan Tykocki, Ph.D.
Pharmacology & Toxicology
Dr. Nathan Tykocki
B436 Life Sciences
1355 Bogue Street
East Lansing, MI 48824
- 2012 - Ph.D., Pharmacology and Toxicology Michigan State University, East Lansing, MI
- Dissertation Title: “Endothelin-1-induced calcium signaling in arteries and veins”
- 2002 - B.S., Science and Technology Studies Lyman Briggs College, Michigan State University
My research focuses on urinary bladder physiology, with specific emphasis on the mechanisms responsible for the sensation of bladder fullness. We employ a multi-disciplinary approach, including biochemical, pharmacological, physiological and genetic tools, to understand how the bladder muscle, nerves, vasculature and urothelium communicate to impact bladder function. My work discovered that: (1) transient contractions of the bladder wall generate bursts of afferent nerve activity that dominate sensory outflow from the bladder; and (2) the vasculature of the urinary bladder, due to the unique physiological demands it experiences during bladder filling, possesses distinct contractile properties versus other vessels of similar size.
Two funded projects are currently underway in my lab. First, we are investigating how alterations in urinary bladder blood flow and vascular contractility affect bladder function, both normally and in diabetes. Second, we are exploring how the duration/intensity of social stress causes bladder dysfunction and determining the roles of transient receptor potential channels (specifically TRPV1) play in the progression of stress-induced bladder dysfunction.
My scientific training explored vascular smooth muscle biology, physiology and pharmacology, specifically in terms of calcium signaling pathways as regulators of smooth muscle contractility. My fields of expertise include myography, receptor pharmacology, confocal microscopy, fluorescence microscopy, calcium imaging, western blotting, immunofluorescence, and instrument design/fabrication.
- Best Basic Science Poster Award, Society for Urodynamics, Female Pelvic Medicine & Urogenital Reconstruction (SUFU) Annual Conference, 2018
- Fellow, Journal of General Physiology Junior Faculty Networking Cohort, 2017