Xiaochun Bian, Ph.D.
Pharmacology & Toxicology
B308 Life Sciences
1355 Bogue Street
East Lansing, MI 48824
Fields of Interest: My research interest is focused on postnatal development of the enteric nervous system (ENS) with special emphasis on pediatric related neurogastrointestinal issues.
- 1996- BSc, Anatomy and Cell Biology, University of Melbourne/Australia
- 2001 - Ph.D., Physiology, University of Melbourne/Australia
- 2001-2005- Visiting Research Associate (with Dr. J. Galligan), Pharmacology and Toxicology, Michigan State University
- 2006-present - Assistant Professor, Pharmacology and Toxicology, Michigan State University
Biography & Current Research
My research interest is focused on postnatal development of the enteric nervous system (ENS) with special emphasis on pediatric related neurogastrointestinal issues. Most research on the development of the ENS and/or the gastrointestinal (GI) tract has mainly focused on prenatal period with little attention given to postnatal maturation. Knowledge of postnatal development of neurohumoral signaling mechanism in the gut is important since pediatrics-related GI disorders may be associated with impaired postnatal maturation of the GI tract and the ENS, and, these disorders place a large burden on the affected children and on their families. The research will use a multi-disciplinary approach which includes:
- continuous amperometry for real time measurements of neurohumoral signaling molecules
- that play important roles for the postnatal development of the GI tract and the ENS,
- organ bath pharmacology for in vitro functional studies in whole mount GI preparations made
- from neonatal and adult animals,
- immunohistochemistry and molecular biology to detect specific proteins participating in
- neurohumoral signaling in the ENS and
- electrophysiology to record from enteric neurons or smooth muscle cells in vitro in acutely
- isolated preparations from neonatal and adult GI tissues.
Postnatal development of neurohumoral signaling mechanisms in the gut.
Awards & Achievements
- 1996-2000 Melbourne Research Scholarship awarded by University of Melbourne, Australia
- 2006 Travel Award by Development of the Enteric Nervous System, USA
- 2006 Travel Award by American Motility Society Joint International Meeting, USA
- 2008-2009 MSU IRGP Award awarded by Michigan State University, USA
Committees & Activities
- Course Coordinator of PHM 810 (Synaptic Transmission)
- ad hoc reviewer for a number of international physiology journals.
- Invited participant of the XIth Little Brain Big Brain (LBBB) meeting, USA
Full list of articles at MSU Scholars
- Improvements in the Formation of Boron-Doped Diamond Coatings on Platinum Wires Using the Novel Nucleation Process (NNP). Fhaner M, Zhao H, Bian X, Galligan JJ, Swain GM. Diam Relat Mater. 2011 Feb;20(2):75-83. PMID: 21617759 [PubMed] Free PMC Article
- Electrochemical measurements of serotonin (5-HT) release from the guinea pig mucosa using continuous amperometry with a boron-doped diamond microelectrode. Zhao H, Bian X, Galligan JJ, Swain GM. Diam Relat Mater. 2010 Feb;19(2-3):182-185. PMID: 20209031 [PubMed] Free PMC Article
- From 'macro' to 'micro': mapping the neuronal circuits of the intestine. Bertrand PP, Bian X. Clin Exp Pharmacol Physiol. 2008 Jul;35(7):715-6. doi: 10.1111/j.1440-1681.2008.04974.x. No abstract available. PMID: 18498532 [PubMed - indexed for MEDLINE]
- Diamond microelectrodes for in vitro electroanalytical measurements: current status and remaining challenges. Park J, Quaiserová-Mocko V, Patel BA, Novotný M, Liu A, Bian X, Galligan JJ, Swain GM. Analyst. 2008 Jan;133(1):17-24. Epub 2007 Aug 28. PMID: 18087609 [PubMed - indexed for MEDLINE]
- High mucosal serotonin availability in neonatal guinea pig ileum is associated with low serotonin transporter expression. Bian X, Patel B, Dai X, Galligan JJ, Swain G. Gastroenterology. 2007 Jun;132(7):2438-47. Epub 2007 Apr 13.PMID: 17570217 [PubMed - indexed for MEDLINE]