Hui Xu, M.D., Ph.D.

  • Cardiovascular Staff, Drug Discovery and Receptor Faculty

Pharmacology & Toxicology
Associate Professor
B329 Life Sciences Building
1355 Bogue Street
East Lansing, MI 48824
Email: xuhui2@msu.edu
Phone: 517-353-6609
Fax: 517-353-8915

Fields of Interest: My research works focus on the autonomic nervous system, molecular signaling and receptor/ion channel interaction in the vasculature, and how these factors regulate smooth muscle and vascular tone in health and human diseases.

 

Hui Xu on MSU Scholars

Educational Background

  • 1983 - M.D., Xinjiang Medical University, China
  • 1999 - Ph.D., Kagawa Medical University, Japan
  • 2000 - Visiting Scientist, Anesthesiology, University of Arkansas Medical School
  • 2000-05 - Research Associate (with Dr. J. Galligan), Pharmacology & Toxicology, Michigan State University
  • 2005-present - Assistant Professor, Pharmacology & Toxicology, Michigan State University

Biography & Current Research

Research Synopsis

My overall approach is highly integrative as I study in whole animal (in rats and mice) in vivo, nerve and smooth muscle interaction in vitro, and the molecular function at the level of individual ion channels/receptors. One of my recent studies focus on the role of interaction between ion channels and receptors in regulation of smooth muscle tone and the possible role of ion channel dysfunction in hypertension and septic shock, as well as an innovative role of vascular potassium channel function in protecting against sepsis and obesity associated organ damage.

Techniques used include

  • Integrated cardiovascular function in vivo animal by measurements of blood pressure, heart rate, and renal sympathetic nerve activity; measurements of small mesenteric arterial and venous contractile and relaxation reactive in ex-vivo; and measurements of smooth muscle membrane potential using intracellular recording in ex vivo.
  • Measurements of blood volume, organ blood flow in vivo.
  • Pharmacological studies of arterial and venous functions in vitro using pressurized myograph.
  • Molecular biological approaches to analyze the vascular structures, expression and interaction of receptors, ion channels, and intracellular signal conductors in arteries and veins.
  • Ion channel functions are determined in myocytes from arteries and veins. Approaches include whole cell, cell attached and inside out signal channel patches; recording of spontaneous outward currents and Ca2+ sparks.

Awards & Achievements

  • American Heart Association Postdoctoral Fellowship – 2003-2005
  • Young Scientist Travel Award Recipient for the Experimental Biology Meeting 2004,
  • New Investigator Travel Award for the Jackson Cardiovascular-Renal Meeting, 2008
  • New Investigator Travel Award for the IUPS 2009 Congress, from International Physiology Committee and the Council of the American Physiological Society, 2009.
  • American Heart Association Grant–in-Aid award, 2011-2013

Committees & Activities

Grant Reviewer

  • 2011- present: - American Heart Association SURF Study Section Reviewer Roster
  • 2012- present: - American Heart Association IRG-Vascular Regulation and Diseases Study Section Reviewer Roster.

Editorial Activity

  • 2013-2014:- Guest Editor, BioMed Research International-Special Issue-Obesity, Diabetes, and Cardiometabolic Syndrome
  • 2014-present:- Editorial Board of Pharmacology and Alternative Medicine Therapeutics
  • 2014-present:- Editorial Board of Journal of Cardiovascular Disorder

Ad Hoc Peer Reviewer

Circulation, Journal of Clinical Investigation, Hypertension, Cardiovascular Research, Journal of Physiology, American Journal of Physiology Heart and Circulatory Physiology, American Journal of Physiology Regulatory, Integrative and Comparative Physiology, Am J Hypertension, Journal of Pharmacology and Experimental Therapeutics, J Hypertension, Journal of American Applied Physiology, Life Science, Pharmacological Research, Vascular Pharmacology, Metabolism, Expert Opinion on Drug Discovery

Publications

Full list of articles at MSU Scholars

  • Wang Y, Zhu M, Xu H, Cui L, Liu W, Wang X, Shen S, Wang DH. Role of the monocyte chemoattractant protein-1/C-C chemokine receptor 2 signaling pathway in transient receptor potential vanilloid type 1 ablation-induced renal injury in salt-sensitive hypertension. Exp Biol Med (Maywood). 240:1223-1232, 2015.
  • Xu H, Garver H, Phelps JT, Fernandes R, Fink GD, Galligan JJ. BK channel β1-subunit deficiency exacerbates vascular fibrosis and remodelling but does not promote hypertension in high-fat fed obesity in mice. J Hypertens. 33:1611-23, 2015.
  • Bhattarai Y, Fernandes R, Kadrofske M, Lockwood B, Galligan JJ, Xu H. Western blot analysis of BK channel β1-subunit expression should be interpreted cautiously when using commercially available antibodies. Physiol Rep. 28;2(10), 2014.
  • Xu H, Garver H, Fernandes R, Galligan JJ, Fink GD. Altered L-type Ca2+ channel activity contributes to exacerbated mortality and organ damage in smooth muscle cell BK channel deficient septic mice. Am J Physiol Regul Integr Comp Physiol. 307(2):R138-48, 2014.
  • Sangsiri S, Dong H, Swain GM, Galligan JJ, Xu H. Impaired function of prejunctional adenosine A1 receptors expressed by perivascular sympathetic nerves in DOCA-salt hypertensive rats. J Pharmacol Exp Ther. 345:32-40, 2013.
  • France M, Bhattarai Y, Galligan JJ, Xu H. Impaired propulsive motility in the distal but not proximal colon of BK channel β1-subunit knockout mice. Neurogastroenterol Motil. 24:e450-459, 2012
  • Xu H, Wang Y, Garver H, Galligan JJ, Fink GD: BK Channel ?1-subunit deficiency exaggerates organ damage and mortality in endotoxemic mice. J Cardiovas. Pharmcol. 59:207-14, 2012 (Editors’ Pick up).
  • Xu H, Kandlikar SS, Westcott EB, Fink GD, Galligan JJ: Requirement for functional BK channels in maintaining oscillation in venomotor tone revealed by species differences in expression of the β1 accessory subunits. J Cardiovasc Pharmacol. 59(1):29-36, 2012
  • Xu H, Garver H, Galligan JJ, Fink GD: Large conductance Ca2+-activated K+ channel β1-subunit knockout mice are not hypertensive. Am J Physiol Heart Circ Physiol. 300(2): H476-85, 2011.