Yukun Yuan, B.M. (M.D.), M.M. (M.S.), Ph.D.
Pharmacology & Toxicology
Dr. Yukun Yuan
B307A Life Sciences Building
1355 Bogue Street
East Lansing, MI 48824
Fields of Interest: My research interests are in the fields of neurotoxicology, neuropharmacology/neurophysiology and neurological disorders. Specifically, my research focus on channelopathy-related neurological disorders such as epilepsy and Amyotrophic Lateral Sclerosis (ALS), developmental effects of environmental contaminants on synaptic transmission (particularly synaptic specificity and synaptic plasticity) in the mammalian central nervous system (CNS) and the contributions of gene-environment interactions to the etiology of neurological disorders such as Amyotrophic Lateral Sclerosis (ALS), epilepsy and demyelination resulting from mutation or dysfunction of a specific type of ion channels in the CNS.
- 1978-83 - B.M. (M.D.), Medicine/Public Health, Zhengzhou University Medical School (former Henan Medical University), Zhengzhou, China
- 1983-85: - Assistant Lecturer, Occupational Diseases & Toxicology, Zhengzhou University Medical School (former Henan Medical University), Zhengzhou, China
- 1985-88 - M.M. (M.S.), Biochemical Toxicology, Peking University Health Science Center (former Beijing Medical University), Beijing, China
- 1988-90 - Lecturer, Toxicology, Peking University Health Science Center (former Beijing Medical University), Beijing, China
- 1991-93 - Visiting Scientist, Pharmacology & Toxicology, Michigan State University
- 1993-97 - Ph.D., Pharmacology and Toxicology, Michigan State University
- 1997-00 - Postdoctoral fellow, Ophthalmology and Visual Sciences, University of Michigan
- 2000-present - Assistant Professor, Pharmacology & Toxicology, Michigan State University
My primary research interest is neurotoxicology. Current studies focus primarily on developmental effects of some environmental contaminants on central synaptic function (particularly synaptic transmission and plasticity in the visual cortex) of the mammalian central nervous system (CNS). Specific questions include why some chemicals selectively or preferentially target at certain populations of neurons or regions of the brain, and what is the cellular and molecular bases responsible for these preferential effects. My other research interests include role of gene-environment interaction in the etiology of neurological disorders and channelopathy-related neurological disorders such as epilepsy and axonal demyelination resulting from mutation or dysfunction of a specific type of ion channels in the CNS.
- Neurotoxicity of methylmercury in the visual cortex.
- First Place Award for graduate student presentation from the Neurotoxicology Specialty Section of Society of Toxicology, 1994.
- Third Place Award for graduate student presentation from the Neurotoxicology Specialty Section of Society of Toxicology, 1996.
- Graduate Student Travel Award from Society of Toxicology, 1997.
- Postdoctoral fellow Travel Award from the Association for Research in Vision and Ophthalmology, 1999
- Michigan State University Internal Research Funding Award, 2006-2009
- 2009-present - Editorial Board Member of Neurotoxicology
- 2014-present - Alumni Relation and Development Committee, Department of Pharmacology/Toxicology
- Yuan Y, Isom L.L.: SUMOylation of neuronal K+ channels: a potential therapeutic pathway for epilepsy and SUDEP. Neuron 83:996-998, 2014.
- Liu Y*, Lopez-Santiago LF*, Yuan Y*, Jones JM, Zhang H, O'Malley HA, Patino GA, O'Brien JE, Rusconi R, Gupta A, Thompson RC, Natowicz MR, Meisler MH, Isom LL, Parent JM. Dravet syndrome patient-derived neurons suggest a novel epilepsy mechanism. Ann Neurol. 74:128-139, 2013 2013 (*Co-first authors).
- Brackenbury WJ*, Yuan Y*, O'Malley HA, Parent JM, Isom LL. Abnormal neuronal patterning occurs during early postnatal brain development of Scn1b-null mice and precedes hyperexcitability. Proc Natl Acad Sci U S A. 110:1089-1094, 2013 (*Co-first authors).
- Yuan Y. Methylmercury: a potential environmental risk factor contributing to epileptogenesis. Neurotoxicology. 33:119-126, 2012.
- Dasari S, Yuan Y.: Methylmercury exposure in vivo induces a long-lasting epileptiform activity in layer II/III neurons in cortical slices of rat. Toxicol. Lett. 193, 138-143. 2010.
- Dasari S, Yuan Y.: Low levels postnatal methylmercury exposure in vivo alters developmental forms of short-term synaptic plasticity in the visual cortex of rats. Toxicol Appl Pharmacol 240: 412-422, 2009.
Additional articles at PubMed