Fields of Interest: The goal of research in my laboratory is to develop a murine model for periodic limb movements employing neurotoxin-induced lesions of the A11 diencephalospinal dopamine neurons and remote sensing assessment of hindlimb during the awake/sleep cycle.
Fields of Interest: The research in my laboratory is focused on understanding the role of the immune system and hypoxia in the development of liver disease.
Fields of Interest: My research concerns the causes of systemic arterial hypertension, a major world-wide risk factor for cardiovascular disease morbidity and mortality.
Fields of Interest: My research interests are focused on genetic and environmental factors involved in the pathogenesis of neuro-degenerative disorders such as Parkinson's Disease (PD).
Fields of Interest: Elucidation of the molecular mechanisms for impairment of signal transduction cascades and gene expression during lymphocyte activation by drugs and chemicals; mechanism for immune modulation by cannabinoid compounds
Fields of Interest: "Purinergic neurotransmission in the intestine", "Neural control of arteries and veins in hypertension", "SERT KO rats are a model of sex specific
Fields of Interest: Examination of how arterioles in the microcirculation sense their environment; the role of smooth muscle and endothelial cell ion channels in the regulation of calcium signaling; vascular cell signaling related to vasodilation and vasoconstriction.
Fields of Interest: My research works focus on the autonomic nervous system, molecular signaling and receptor/ion channel interaction in the vasculature, and how these factors regulate smooth muscle and vascular tone in health and human diseases.
Fields of Interest:
The liver synthesizes numerous coagulation factors, making altered hemostasis a significant concern in patients with end-stage liver disease. Our laboratory approaches this connection early in the pathogenesis of liver disease. The team’s long-term goal is to understand the mechanisms whereby the coagulation cascade contributes to the pathogenesis of liver disease. [excerpt, Luyendyk Laboratory site]
Fields of Interest: G protein-coupled receptor (GPCR) signaling and intracellular modulators of that signaling. GPCRs are the targets of over 30% of current drugs and we are discovering novel ways to control their function.
