Recent Publications

Tuning the signal: ATP-sensitive K⁺ channels direct blood flow to cerebral capillaries.

Jackson WF.Sci Signal. 2022 Mar 29;15(727):eabo1118. doi: 10.1126/scisignal.abo1118. Epub 2022 Mar 29.PMID: 35349301 Review.

A Dual-Reporter Platform for Screening Tumor-Targeted Extracellular Vesicles.

Kanada M, Linenfelser L, Cox E, Gilad AA.Pharmaceutics. 2022 Feb 22;14(3):475. doi: 10.3390/pharmaceutics14030475.PMID: 35335849 Free PMC article.

Remodeling of extracellular matrix in the urinary bladder of paraplegic rats results in increased compliance and delayed fiber recruitment 16 weeks after spinal cord injury.

Tuttle TG, Lujan HL, Tykocki NR, DiCarlo SE, Roccabianca S. Acta Biomater. 2022 Mar 15;141:280-289. doi: 10.1016/j.actbio.2022.01.015. Epub 2022 Jan 13. PMID: 35032719

Antitumor and multikinase inhibition activities of some synthesized coumarin and benzofuran derivatives.

Ahmed EY, Abdelhafez OM, Zaafar D, Serry AM, Ahmed YH, El-Telbany RFA, Abd Elmageed ZY, Ali HI. Arch Pharm (Weinheim). 2022 Mar 14:e2100327. doi: 10.1002/ardp.202100327. Online ahead of print. PMID: 35285986

 

Cell cycle checkpoints and beyond: Exploiting the ATR/CHK1/WEE1 pathway for the treatment of PARP inhibitor-resistant cancer.

Gupta N, Huang TT, Horibata S, Lee JM. Pharmacol Res. 2022 Mar 5;178:106162. doi: 10.1016/j.phrs.2022.106162. Online ahead of print. PMID: 35259479 Review.

 

Suppression of fibrin(ogen)-driven pathologies in disease models through controlled knockdown by lipid nanoparticle delivery of siRNA.

Juang LJ, Hur WS, Silva LM, Strilchuk AW, Francisco B, Leung J, Robertson MK, Groeneveld DJ, La Prairie B, Chun EM, Cap AP, Luyendyk JP, Palumbo JS, Cullis PR, Bugge TH, Flick MJ, Kastrup CJ. Blood. 2022 Mar 3;139(9):1302-1311. doi: 10.1182/blood.2021014559. PMID: 34958662

 

Histamine receptors rapidly desensitize without altering nerve-evoked contractions in murine urinary bladder smooth muscle.

Jones BM, Mingin GC, Tykocki NR. Am J Physiol Renal Physiol. 2022 Mar 1;322(3):F268-F279. doi: 10.1152/ajprenal.00355.2021. Epub 2022 Jan 24. PMID: 35073211

The rexinoid V-125 reduces tumor growth in preclinical models of breast and lung cancer.

Reich LA, Moerland JA, Leal AS, Zhang D, Carapellucci S, Lockwood B, Jurutka PW, Marshall PA, Wagner CE, Liby KT. Sci Rep. 2022 Jan 7;12(1):293. doi: 10.1038/s41598-021-04415-0. PMID: 34997154 Free PMC article.

Endothelial Ion Channels and Cell-Cell Communication in the Microcirculation.

Jackson WF. Front Physiol. 2022 Feb 8;13:805149. doi: 10.3389/fphys.2022.805149. eCollection 2022. PMID: 35211031 Free PMC article. Review.

 

Cross-linking by tissue transglutaminase-2 alters fibrinogen-directed macrophage proinflammatory activity.

Poole LG, Kopec AK, Flick MJ, Luyendyk JP. J Thromb Haemost. 2022 Feb 14. doi: 10.1111/jth.15670. Online ahead of print. PMID: 35158413

 

Building vs. Rebuilding Epidermis: Comparison Embryonic Development and Adult Wound Repair.

Park S. Front Cell Dev Biol. 2022 Jan 25;9:796080. doi: 10.3389/fcell.2021.796080. eCollection 2021. PMID: 35145968 Free PMC article. Review.

 

Community Guidelines for GPCR Ligand Bias: IUPHAR Review XX.

Kolb P, Kenakin T, Alexander SPH, Bermudez M, Bohn LM, Breinholt CS, Bouvier M, Hill SJ, Kostenis E, Martemyanov K, Neubig RR, Onaran HO, Rajagopal S, Roth BL, Selent J, Shukla AK, Sommer ME, Gloriam DE. Br J Pharmacol. 2022 Feb 1. doi: 10.1111/bph.15811. Online ahead of print. PMID: 35106752 Review.

 

TAAR1 regulates drug-induced reinstatement of cocaine-seeking via negatively modulating CaMKIIα activity in the NAc.

Liu J, Wu R, Seaman R Jr, Manz KM, Johnson B, Vu J, Huang Y, Zhang Y, Robison AJ, Neve R, Grueter BA, Dietz D, Li JX. Mol Psychiatry. 2022 Jan 25. doi: 10.1038/s41380-022-01448-3. Online ahead of print. PMID: 35079125

 

Histamine receptors rapidly desensitize without altering nerve-evoked contractions in murine urinary bladder smooth muscle.

Jones BM, Mingin GC, Tykocki NR. Am J Physiol Renal Physiol. 2022 Mar 1;322(3):F268-F279. doi: 10.1152/ajprenal.00355.2021. Epub 2022 Jan 24. PMID: 35073211

 

Time to drink: Activating lateral hypothalamic area neurotensin neurons promotes intake of fluid over food in a time-dependent manner.

Kurt G, Kodur N, Quiles CR, Reynolds C, Eagle A, Mayer T, Brown J, Makela A, Bugescu R, Seo HD, Carroll QE, Daniels D, Robison AJ, Mazei-Robison M, Leinninger G. Physiol Behav. 2022 Apr 1;247:113707. doi: 10.1016/j.physbeh.2022.113707. Epub 2022 Jan 19. PMID: 35063424 Free article.

 

Bisphenol S Impairs Invasion and Proliferation of Extravillous Trophoblasts Cells by Interfering with Epidermal Growth Factor Receptor Signaling.

Ticiani E, Pu Y, Gingrich J, Veiga-Lopez A. Int J Mol Sci. 2022 Jan 8;23(2):671. doi: 10.3390/ijms23020671. PMID: 35054855 Free PMC article.

 

Loss of Health Promoting Bacteria in the Gastrointestinal Microbiome of PICU Infants with Bronchiolitis: A Single-Center Feasibility Study.

Russell MM, Leimanis-Laurens ML, Bu S, Kinney GA, Teoh ST, McKee RL, Ferguson K, Winters JW, Lunt SY, Prokop JW, Rajasekaran S, Comstock SS. Children (Basel). 2022 Jan 17;9(1):114. doi: 10.3390/children9010114. PMID: 35053739 Free PMC article.

 

Remodeling of extracellular matrix in the urinary bladder of paraplegic rats results in increased compliance and delayed fiber recruitment 16 weeks after spinal cord injury.

Tuttle TG, Lujan HL, Tykocki NR, DiCarlo SE, Roccabianca S. Acta Biomater. 2022 Jan 13:S1742-7061(22)00016-2. doi: 10.1016/j.actbio.2022.01.015. Online ahead of print. PMID: 35032719

 

Outcomes of SARS-CoV-2-Positive Youths Tested in Emergency Departments: The Global PERN-COVID-19 Study.

Funk AL, Florin TA, Kuppermann N, Tancredi DJ, Xie J, Kim K, Neuman MI, Ambroggio L, Plint AC, Mintegi S, Klassen TP, Salvadori MI, Malley R, Payne DC, Simon NJ, Yock-Corrales A, Nebhrajani JR, Chaudhari PP, Breslin KA, Finkelstein Y, Campos C, Bergmann KR, Bhatt M, Ahmad FA, Gardiner MA, Avva UR, Shah NP, Sartori LF, Sabhaney VJ, Caperell K, Navanandan N, Borland ML, Morris CR, Gangoiti I, Pavlicich V, Kannikeswaran N, Lunoe MM, Rino PB, Kam AJ, Cherry JC, Rogers AJ, Chong SL, Palumbo L, Angelats CM, Morrison AK, Kwok MY, Becker SM, Dixon AC, Poonai N, Eckerle M, Wassem M, Dalziel SR, Freedman SB; Pediatric Emergency Research Network-COVID-19 Study Team. JAMA Netw Open. 2022 Jan 4;5(1):e2142322. doi: 10.1001/jamanetworkopen.2021.42322. PMID: 35015063 Free PMC article.

 

The rexinoid V-125 reduces tumor growth in preclinical models of breast and lung cancer.

Reich LA, Moerland JA, Leal AS, Zhang D, Carapellucci S, Lockwood B, Jurutka PW, Marshall PA, Wagner CE, Liby KT. Sci Rep. 2022 Jan 7;12(1):293. doi: 10.1038/s41598-021-04415-0. PMID: 34997154 Free PMC article.

 

Disposition of Fluorine on New Firefighter Turnout Gear.

Muensterman DJ, Titaley IA, Peaslee GF, Minc LD, Cahuas L, Rodowa AE, Horiuchi Y, Yamane S, Fouquet TNJ, Kissel JC, Carignan CC, Field JA. Environ Sci Technol. 2022 Jan 18;56(2):974-983. doi: 10.1021/acs.est.1c06322. Epub 2021 Dec 27. PMID: 34961317

 

Something's fishy: cardiovascular ATP-sensitive K⁺ channels in zebrafish.

Jackson WF. J Physiol. 2022 Jan;600(2):169-170. doi: 10.1113/JP282628. Epub 2022 Jan 3. PMID: 34951483 No abstract available.

 

Identification of Piezo1 channels in perivascular adipose tissue (PVAT) and their potential role in vascular function.

Miron TR, Flood ED, Tykocki NR, Thompson JM, Watts SW. Pharmacol Res. 2022 Jan;175:105995. doi: 10.1016/j.phrs.2021.105995. Epub 2021 Nov 21. PMID: 34818570

 

Chronic cerebral hypoperfusion in male rats results in sustained HPA activation and hyperinsulinemia.

Lansdell TA, Dorrance AM. Am J Physiol Endocrinol Metab. 2022 Jan 1;322(1):E24-E33. doi: 10.1152/ajpendo.00233.2021. Epub 2021 Nov 8. PMID: 34747203

 

N-methyl-d-aspartate (NMDA) receptor genetics: The power of paralog homology and protein dynamics in defining dominant genetic variants.

Charron JG, Hernandez A, Bilinovich SM, Vogt DL, Bedinger LA, Seaver LH, Williams M, Devries S, Campbell DB, Bupp CP, Prokop JW. Am J Med Genet A. 2022 Feb;188(2):556-568. doi: 10.1002/ajmg.a.62554. Epub 2021 Nov 2. PMID: 34726335