Karen Liby, PhD
Adjunct Professor
Research
Sections
- PHM 802 Cellular, Molecular and Integrated Systems Pharmacology (in-person) - Spring
Funding
- Chemoprevention of experimental estrogen receptor negative breast cancer, The Breast Cancer Research Foundation Inc. (2023-10-01—2024-09-30)
- Chemoprevention of experimental estrogen receptor negative breast cancer, The Breast Cancer Research Foundation Inc. (2024-10-01—2025-09-30)
- Nrf2, immune cells and lung cancer, National Cancer Institute (2019-04-01—2024-03-31)
- Nanoformulations and Sustained Delivery of PARP Inhibitors for Breast Cancer, Congressionally Directed Medical Research Programs (2016-09-30—2021-09-29)
- 16K Prolactin as an Angiogenic Inhibitor in Breast Cancer, Congressionally Directed Medical Research Programs (1997-10-01—1998-09-01)
- Chemoprevention of experimental estrogen receptor negative breast cancer, The Breast Cancer Research Foundation Inc. (2022-10-01—2023-09-30)
Works
- The BRD4 Inhibitor I-BET-762 Reduces HO-1 Expression in Macrophages and the Pancreas of Mice. International Journal of Molecular Sciences (2024-09-16)
- The Triterpenoid CDDO-Methyl Ester Reduces Tumor Burden, Reprograms the Immune Microenvironment, and Protects from Chemotherapy-Induced Toxicity in a Preclinical Mouse Model of Established Lung Cancer. Antioxidants (2024-05-21)
- KEAP1-Mutant Lung Cancers Weaken Anti-Tumor Immunity and Promote an M2-like Macrophage Phenotype. International Journal of Molecular Sciences (2024-03-20)
- KEAP1-Mutant Lung Cancers Weaken Anti-Tumor Immunity and Promote an M2-like Macrophage Phenotype. International Journal of Molecular Sciences (2024)
- The Multi-Faceted Consequences of NRF2 Activation throughout Carcinogenesis. Molecules and Cells (2023-03-31)
- Ocular injury progression and cornea histopathology from chloropicrin vapor exposure: Relevant clinical biomarkers in mice. Experimental eye research (2023)
- The Novel RXR Agonist MSU-42011 Differentially Regulates Gene Expression in Mammary Tumors of MMTV-Neu Mice. International journal of molecular sciences (2023)
- The Triterpenoid CDDO-Methyl Ester Redirects Macrophage Polarization and Reduces Lung Tumor Burden in a Nrf2-Dependent Manner. Antioxidants (Basel, Switzerland) (2023)
- Exploring structural effects in a new class of NRF2 inhibitors. RSC medicinal chemistry (2022)
- T Cells and CDDO-Me Attenuate Immunosuppressive Activation of Human Melanoma-Conditioned Macrophages. Frontiers in Immunology (2022)
- The rexinoid V-125 reduces tumor growth in preclinical models of breast and lung cancer. Scientific Reports (2022)
- The Rexinoid V-125 Reduces Tumor Growth in Preclinical Models of Breast and Lung Cancer. (2021)
- Meeting Report: Translational Advances in Cancer Prevention Agent Development Meeting. Journal of cancer prevention (2021)
- A novel Nrf2 pathway inhibitor sensitizes keap1-mutant lung cancer cells to chemotherapy. Molecular Cancer Therapeutics (2021)
- Potential therapeutic uses of rexinoids. Advances in Pharmacology (2021)
- Sustained, local delivery of the PARP inhibitor talazoparib prevents the development of mammary gland hyperplasia in Brca1-deficient mice. Scientific Reports (2021)
- The bromodomain inhibitor, incb057643, targets both cancer cells and the tumor microenvironment in two preclinical models of pancreatic cancer. Cancers (2021)
- The rxr agonist msu42011 is effective for the treatment of preclinical her2+ breast cancer and kras-driven lung cancer. Cancers (2021)
- CDDO-Me Alters the Tumor Microenvironment in Estrogen Receptor Negative Breast Cancer. Scientific Reports (2020)
- The novel rexinoid MSU-42011 is effective for the treatment of preclinical Kras-driven lung cancer. Scientific Reports (2020)
- Profiling changes in metabolism and the immune microenvironment in lung tumorigenesis. Annals of translational medicine (2019)
- A nano-liposome formulation of the PARP inhibitor talazoparib enhances treatment efficacy and modulates immune cell populations in mammary tumors of BRCA-deficient mice. Theranostics (2019)
- Identifying chemopreventive agents for obesity-associated cancers using an efficient, 3D high-throughput transformation assay. Scientific Reports (2019)
- Retinoid X receptor agonist LG100268 modulates the immune microenvironment in preclinical breast cancer models. npj Breast Cancer (2019)
- Testing novel pyrimidinyl rexinoids: A new paradigm for evaluating rexinoids for cancer prevention. Cancer Prevention Research (2019)
- The Rho/MRTF pathway inhibitor CCG-222740 reduces stellate cell activation and modulates immune cell populations in Kras G12D ; Pdx1-Cre (KC) mice. Scientific Reports (2019)
- A BET bromodomain inhibitor suppresses adiposity-associated malignant transformation. Cancer Prevention Research (2018)
- Chemoprevention of Preclinical Breast and Lung Cancer with the Bromodomain Inhibitor I-BET 762. Cancer Prevention Research (2018)
- Dehydroabietic oximes halt pancreatic cancer cell growth in the G1 phase through induction of p27 and downregulation of cyclin D1. Scientific Reports (2018)
- Differential effects of the Nrf2 activators tBHQ and CDDO-Im on the early events of T cell activation. Biochemical Pharmacology (2018)
- Identification of an unfavorable immune signature in advanced lung tumors from Nrf2-deficient mice. Antioxidants and Redox Signaling (2018)
- Murine Models of Pancreatitis Leading to the Development of Pancreatic Cancer. Current Protocols in Pharmacology (2018)
- Bromodomain inhibitors, JQ1 and I-BET 762, as potential therapies for pancreatic cancer. (2017)
- Bromodomain inhibitors, JQ1 and I-BET 762, as potential therapies for pancreatic cancer. Cancer Letters (2017)
- Nrf2-Dependent and -Independent Effects of tert-Butylhydroquinone, CDDO-Im, and H2O2 in Human Jurkat T Cells as Determined by CRISPR/Cas9 Gene Editing. (2017)
- Nrf2-Dependent and -Independent Effects of tert-Butylhydroquinone, CDDO-Im, and H2O2 in Human Jurkat T Cells as Determined by CRISPR/Cas9 Gene Editing. Journal of Pharmacology and Experimental Therapeutics (2017)
- Design, synthesis, and biological activity of second-generation synthetic oleanane triterpenoids. Organic and Biomolecular Chemistry (2017)
- NRF2 as an Emerging Therapeutic Target. (2017)
- NRF2 as an emerging therapeutic target. Oxidative Medicine and Cellular Longevity (2017)
- Rexinoids for prevention and treatment of cancer: Opportunities and challenges. Current Topics in Medicinal Chemistry (2017)
- Sustained release Talazoparib implants for localized treatment of Brca1-deficient breast cancer. Theranostics (2017)
- Synthetic oleanane triterpenoids enhance blood brain barrier integrity and improve survival in experimental cerebral malaria. Malaria Journal (2017)
- The triterpenoid CDDO-imidazolide reduces immune cell infiltration and cytokine secretion in the KrasG12D;Pdx1-Cre (KC) mouse model of pancreatic cancer. (2016)
- Rexinoids for prevention and treatment of cancer: opportunities and challenges. (2016)
- The Rexinoids LG100268 and LG101506 Inhibit Inflammation and Suppress Lung Carcinogenesis in A/J Mice. (2016)
- The rexinoids LG100268 and LG101506 inhibit inflammation and suppress lung carcinogenesis in A/J mice. Cancer Prevention Research (2016)
- CDDO-Me Redirects Activation of Breast Tumor Associated Macrophages. (2016)
- CDDO-Me redirects activation of breast tumor associated macrophages. PLoS ONE (2016)
- The triterpenoid CDDO-imidazolide reduces immune cell infiltration and cytokine secretion in the KrasG12D;Pdx1-Cre (KC) mouse model of pancreatic cancer. Carcinogenesis (2016)
- Novel synthetic pyridyl analogues of CDDO-Imidazolide are useful new tools in cancer prevention. (2015)
- Novel synthetic pyridyl analogues of CDDO-Imidazolide are useful new tools in cancer prevention. Pharmacological Research (2015)
- Dimethyl fumarate and the oleanane triterpenoids, CDDO-imidazolide and CDDO-methyl ester, both activate the Nrf2 pathway but have opposite effects in the A/J model of lung carcinogenesis. (2015)
- Dimethyl fumarate and the oleanane triterpenoids, CDDO-imidazolide and CDDO-methyl ester, both activate the Nrf2 pathway but have opposite effects in the A/J model of lung carcinogenesis. Carcinogenesis (2015)
- Erratum to Receptor tyrosine kinase ERBB4 mediates acquired resistance to ERBB2 inhibitors in breast cancer cells (Cell Cycle, 14, 4 (648-655), 10.4161/15384101.2014.994966). Cell Cycle (2015)
- Receptor tyrosine kinase ERBB4 mediates acquired resistance to ERBB2 inhibitors in breast cancer cells. (2015)
- Receptor tyrosine kinase ERBB4 mediates acquired resistance to ERBB2 inhibitors in breast cancer cells. Cell Cycle (2015)
- The synthetic triterpenoid (CDDO-Im) inhibits STAT3, as well as IL-17, and improves DSS-induced colitis in mice. (2014)
- The synthetic triterpenoid (CDDO-Im) inhibits STAT3, as well as IL-17, and improves DSS-induced colitis in mice. Inflammopharmacology (2014)
- PARP inhibitors for chemoprevention--reply. (2014)
- PARP inhibitors for chemoprevention - Reply. Cancer Prevention Research (2014)
- An efficient synthesis of methyl 2-cyano-3,12-dioxoursol-1,9-dien-28-oate (CDDU-methyl ester): analogues, biological activities, and comparison with oleanolic acid derivatives. (2014)
- An efficient synthesis of methyl 2-cyano-3,12-dioxoursol-1,9-dien-28-oate (CDDU-methyl ester): Analogues, biological activities, and comparison with oleanolic acid derivatives. Organic and Biomolecular Chemistry (2014)
- The PARP inhibitors, veliparib and olaparib, are effective chemopreventive agents for delaying mammary tumor development in BRCA1-deficient mice. (2014)
- The PARP inhibitors, veliparib and olaparib, are effective chemopreventive agents for delaying mammary tumor development in BRCA1-deficient mice. Cancer Prevention Research (2014)
- Synthesis and biological evaluation of amino acid methyl ester conjugates of 2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oic acid against the production of nitric oxide (NO). (2014)
- Synthesis and biological evaluation of amino acid methyl ester conjugates of 2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oic acid against the production of nitric oxide (NO). Bioorganic and Medicinal Chemistry Letters (2014)
- Synthetic triterpenoids can protect against toxicity without reducing the efficacy of treatment with Carboplatin and Paclitaxel in experimental lung cancer. (2014)
- Synthetic triterpenoids can protect against toxicity without reducing the efficacy of treatment with carboplatin and paclitaxel in experimental lung cancer. Dose-Response (2014)
- A synthetic triterpenoid CDDO-Im inhibits tumorsphere formation by regulating stem cell signaling pathways in triple-negative breast cancer. (2014)
- A synthetic triterpenoid cddo-im inhibits tumorsphere formation by regulating stem cell signaling pathways in triple-negative breast cancer. PLoS ONE (2014)
- Oral administration of a gemini vitamin D analog, a synthetic triterpenoid and the combination prevents mammary tumorigenesis driven by ErbB2 overexpression. (2013)
- Oral administration of a Gemini vitamin D analog, a synthetic triterpenoid and the combination prevents mammary tumorigenesis driven by ErbB2 overexpression. Cancer Prevention Research (2013)
- Is lycopene an effective agent for preventing prostate cancer?. (2013)
- Targeting Nrf2-mediated gene transcription by extremely potent synthetic triterpenoids attenuate dopaminergic neurotoxicity in the MPTP mouse model of Parkinson's disease. (2013)
- Targeting nrf2-mediated gene transcription by extremely potent synthetic triterpenoids attenuate dopaminergic neurotoxicity in the MPTP mouse model of parkinson's disease. Antioxidants and Redox Signaling (2013)
- The combination of the histone deacetylase inhibitor vorinostat and synthetic triterpenoids reduces tumorigenesis in mouse models of cancer. (2013)
- The combination of the histone deacetylase inhibitor vorinostat and synthetic triterpenoids reduces tumorigenesis in mouse models of cancer. Carcinogenesis (2013)
- ΔNp63α-mediated activation of bone morphogenetic protein signaling governs stem cell activity and plasticity in normal and malignant mammary epithelial cells. (2013)
- Δnp63α-mediated activation of bone morphogenetic protein signaling governs stem cell activity and plasticity in normal and malignant mammary epithelial cells. Cancer Research (2013)
- A mini-review of chemoprevention of cancer - past, present, and future. Progress in Chemistry (2013)
- Synthetic oleanane triterpenoids: multifunctional drugs with a broad range of applications for prevention and treatment of chronic disease. (2012)
- Synthetic oleanane triterpenoids: Multifunctional drugs with a broad range of applications for prevention and treatment of chronic disease. Pharmacological Reviews (2012)
- NRF2 and cancer: the good, the bad and the importance of context. (2012)
- NRF2 and cancer: The Good, the bad and the importance of context. Nature Reviews Cancer (2012)
- The synthetic triterpenoid CDDO-methyl ester delays estrogen receptor-negative mammary carcinogenesis in polyoma middle T mice. (2012)
- The synthetic triterpenoid CDDO-methyl ester delays estrogen receptor-negative mammary carcinogenesis in polyoma middle T mice. Cancer Prevention Research (2012)
- CDDO-methyl ester delays breast cancer development in BRCA1-mutated mice. (2012)
- CDDO-methyl ester delays breast cancer development in Brca1-mutated mice. Cancer Prevention Research (2012)
- Neuroprotective effect of Nrf2/ARE activators, CDDO ethylamide and CDDO trifluoroethylamide, in a mouse model of amyotrophic lateral sclerosis. (2011)
- Neuroprotective effect of Nrf2/ARE activators, CDDO ethylamide and CDDO trifluoroethylamide, in a mouse model of amyotrophic lateral sclerosis. Free Radical Biology and Medicine (2011)
- CDDO-imidazolide induces DNA damage, G2/M arrest and apoptosis in BRCA1-mutated breast cancer cells. (2011)
- CDDO-imidazolide induces DNA damage, G2/M arrest and apoptosis in BRCA1-mutated breast cancer cells. Cancer Prevention Research (2011)
- New synthetic triterpenoids: potent agents for prevention and treatment of tissue injury caused by inflammatory and oxidative stress. (2011)
- New synthetic triterpenoids: Potent agents for prevention and treatment of tissue injury caused by inflammatory and oxidative stress. Journal of Natural Products (2011)
- The synthetic triterpenoid CDDO-Imidazolide suppresses experimental liver metastasis. (2011)
- The synthetic triterpenoid CDDO-Imidazolide suppresses experimental liver metastasis. Clinical and Experimental Metastasis (2011)
- Proteomic analysis shows synthetic oleanane triterpenoid binds to mTOR. (2011)
- Proteomic analysis shows synthetic oleanane triterpenoid binds to mTOR. PLoS ONE (2011)
- Triterpenoid modulation of IL-17 and Nrf-2 expression ameliorates neuroinflammation and promotes remyelination in autoimmune encephalomyelitis. (2011)
- Triterpenoid modulation of IL-17 and Nrf-2 expression ameliorates neuroinflammation and promotes remyelination in autoimmune encephalomyelitis. Scientific Reports (2011)
- Synthetic triterpenoids prolong survival in a transgenic mouse model of pancreatic cancer. (2010)
- Synthetic triterpenoids prolong survival in a transgenic mouse model of pancreatic cancer. Cancer Prevention Research (2010)
- Triterpenoids CDDO-ethyl amide and CDDO-trifluoroethyl amide improve the behavioral phenotype and brain pathology in a transgenic mouse model of Huntington's disease. (2010)
- Triterpenoids CDDO-ethyl amide and CDDO-trifluoroethyl amide improve the behavioral phenotype and brain pathology in a transgenic mouse model of Huntington's disease. Free Radical Biology and Medicine (2010)
- 2-Cyano-3,10-dioxooleana-1,9(11)-dien-28-oic acid anhydride. A novel and highly potent anti-inflammatory and cytoprotective agent. (2010)
- 2-Cyano-3,10-dioxooleana-1,9(11)-dien-28-oic acid anhydride. A novel and highly potent anti-inflammatory and cytoprotective agent. Bioorganic and Medicinal Chemistry Letters (2010)
- Anti-inflammatory triterpenoid blocks immune suppressive function of MDSCs and improves immune response in cancer. (2010)
- Anti-inflammatory triterpenoid blocks immune suppressive function of MDSCs and improves immune response in cancer. Clinical Cancer Research (2010)
- Triterpenoids CDDO-methyl ester or CDDO-ethyl amide and rexinoids LG100268 or NRX194204 for prevention and treatment of lung cancer in mice. (2009)
- Triterpenoids CDDO-methyl ester or CDDO-ethyl amide and rexinoids LG100268 or NRX194204 for prevention and treatment of lung cancer in mice. Cancer Prevention Research (2009)
- Synthetic triterpenoids attenuate cytotoxic retinal injury: cross-talk between Nrf2 and PI3K/AKT signaling through inhibition of the lipid phosphatase PTEN. (2009)
- Synthetic triterpenoids attenuate cytotoxic retinal injury: Cross-talk between Nrf2 and PI3K/AKT signaling through inhibition of the lipid phosphatase PTEN. Investigative Ophthalmology and Visual Science (2009)
- The triterpenoid CDDO-imidazolide confers potent protection against hyperoxic acute lung injury in mice. (2009)
- The triterpenoid CDDO-imidazolide confers potent protection against hyperoxic acute lung injury in mice. American Journal of Respiratory and Critical Care Medicine (2009)
- Role of Nrf2 in prevention of high-fat diet-induced obesity by synthetic triterpenoid CDDO-imidazolide. (2009)
- Role of Nrf2 in prevention of high-fat diet-induced obesity by synthetic triterpenoid CDDO-Imidazolide. European Journal of Pharmacology (2009)
- Genetic versus chemoprotective activation of Nrf2 signaling: overlapping yet distinct gene expression profiles between Keap1 knockout and triterpenoid-treated mice. (2009)
- Genetic versus chemoprotective activation of Nrf2 signaling: Overlapping yet distinct gene expression profiles between Keap1 knockout and triterpenoid-treated mice. Carcinogenesis (2009)
- Neuroprotective effects of the triterpenoid, CDDO methyl amide, a potent inducer of Nrf2-mediated transcription. (2009)
- Neuroprotective effects of the triterpenoid, CDDO methyl amide, a potent inducer of Nrf2-mediated transcription. PLoS ONE (2009)
- Triterpenoid CDDO-methylamide improves memory and decreases amyloid plaques in a transgenic mouse model of Alzheimer's disease. (2009)
- Triterpenoid CDDO-methylamide improves memory and decreases amyloid plaques in a transgenic mouse model of Alzheimer's disease. Journal of Neurochemistry (2009)
- Targeting Nrf2 with the triterpenoid CDDO-imidazolide attenuates cigarette smoke-induced emphysema and cardiac dysfunction in mice. (2009)
- Targeting Nrf2 with the triterpenoid CDDO-imidazolide attenuates cigarette smoke-induced emphysema and cardiac dysfunction in mice. Proceedings of the National Academy of Sciences of the United States of America (2009)
- Triterpenoid CDDO-methylamide improves memory and decreases amyloid plaques in a transgenic mouse model of Alzheimer's disease: (Journal of Neurochemistry (2009) 109 (502-512)). Journal of Neurochemistry (2009)
- A novel acetylenic tricyclic bis-(cyano enone) potently induces phase 2 cytoprotective pathways and blocks liver carcinogenesis induced by aflatoxin. (2008)
- A novel acetylenic tricyclic bis-(cyano enone) potently induces phase 2 cytoprotective pathways and blocks liver carcinogenesis induced by aflatoxin. Cancer Research (2008)
- Genetic or pharmacologic amplification of nrf2 signaling inhibits acute inflammatory liver injury in mice. (2008)
- Genetic or pharmacologic amplification of Nrf2 signaling inhibits acute inflammatory liver injury in mice. Toxicological Sciences (2008)
- Prevention and treatment of experimental estrogen receptor-negative mammary carcinogenesis by the synthetic triterpenoid CDDO-methyl Ester and the rexinoid LG100268. (2008)
- Prevention and treatment of experimental estrogen receptor- negative mammary carcinogenesis by the synthetic triterpenoid CDDO-methyl ester and the rexinoid LG100268. Clinical Cancer Research (2008)
- Human neuroblastoma cells rapidly enter cell cycle arrest and apoptosis following exposure to C-28 derivatives of the synthetic triterpenoid CDDO. (2008)
- Human neuroblastoma cells rapidly enter cell cycle arrest and apoptosis following exposure to C-28 derivatives of the synthetic triterpenoid CDDO. Cancer Biology and Therapy (2008)
- The rexinoid LG100268 and the synthetic triterpenoid CDDO-methyl amide are more potent than erlotinib for prevention of mouse lung carcinogenesis. (2008)
- The rexinoid LG100268 and the synthetic triterpenoid CDDO-methyl amide are more potent than erlotinib for prevention of mouse lung carcinogenesis. Molecular Cancer Therapeutics (2008)
- A dicyanotriterpenoid induces cytoprotective enzymes and reduces multiplicity of skin tumors in UV-irradiated mice. (2008)
- A dicyanotriterpenoid induces cytoprotective enzymes and reduces multiplicity of skin tumors in UV-irradiated mice. Biochemical and Biophysical Research Communications (2008)
- Preclinical evaluation of targeting the Nrf2 pathway by triterpenoids (CDDO-Im and CDDO-Me) for protection from LPS-induced inflammatory response and reactive oxygen species in human peripheral blood mononuclear cells and neutrophils. (2007)
- Preclinical evaluation of targeting the Nrf2 pathway by triterpenoids (CDDO-Im and CDDO-Me) for protection from LPS-induced inflammatory response and reactive oxygen species in human peripheral blood mononuclear cells and neutrophils. Antioxidants and Redox Signaling (2007)
- A new rexinoid, NRX194204, prevents carcinogenesis in both the lung and mammary gland. (2007)
- A new rexinoid, NRX194204, prevents carcinogenesis in both the lung and mammary gland. Clinical Cancer Research (2007)
- Novel semisynthetic analogues of betulinic acid with diverse cytoprotective, antiproliferative, and proapoptotic activities. (2007)
- Novel semisynthetic analogues of betulinic acid with diverse cytoprotective, antiproliferative, and proapoptotic activities. Molecular Cancer Therapeutics (2007)
- Triterpenoids and rexinoids as multifunctional agents for the prevention and treatment of cancer. (2007)
- Triterpenoids and rexinoids as multifunctional agents for the prevention and treatment of cancer. Nature Reviews Cancer (2007)
- Novel tricyclic compounds having acetylene groups at C-8a and cyano enones in rings A and C: highly potent anti-inflammatory and cytoprotective agents. (2007)
- Novel tricyclic compounds having acetylene groups at C-8a and cyano enones in rings A and C: Highly potent anti-inflammatory and cytoprotective agents. Journal of Medicinal Chemistry (2007)
- JunB and JunD regulate human heme oxygenase-1 gene expression in renal epithelial cells. (2007)
- JunB and JunD regulate human heme oxygenase-1 gene expression in renal epithelial cells. Journal of Biological Chemistry (2007)
- The synthetic triterpenoids CDDO-methyl ester and CDDO-ethyl amide prevent lung cancer induced by vinyl carbamate in A/J mice. (2007)
- The synthetic triterpenoids CDDO-methyl ester and CDDO-ethyl amide prevent lung cancer induced by vinyl carbamate in A/J mice. Cancer Research (2007)
- Pharmacodynamic characterization of chemopreventive triterpenoids as exceptionally potent inducers of Nrf2-regulated genes. (2007)
- Pharmacodynamic characterization of chemopreventive triterpenoids as exceptionally potent inducers of Nrf2-regulated genes. Molecular Cancer Therapeutics (2007)
- Platforms and networks in triterpenoid pharmacology. Drug Development Research (2007)
- Design, synthesis, and anti-inflammatory activity both in vitro and in vivo of new betulinic acid analogues having an enone functionality in ring A. (2006)
- Design, synthesis, and anti-inflammatory activity both in vitro and in vivo of new betulinic acid analogues having an enone functionality in ring A. Bioorganic and Medicinal Chemistry Letters (2006)
- Nrf2-dependent protection from LPS induced inflammatory response and mortality by CDDO-Imidazolide. (2006)
- Nrf2-dependent protection from LPS induced inflammatory response and mortality by CDDO-Imidazolide. Biochemical and Biophysical Research Communications (2006)
- The synthetic triterpenoid 1-[2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oyl]imidazole blocks nuclear factor-kappaB activation through direct inhibition of IkappaB kinase beta. (2006)
- The synthetic triterpenoid 1-[2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oyl]imidazole blocks nuclear factor-κB activation through direct inhibition of IκB kinase β. Molecular Cancer Therapeutics (2006)
- The combination of the rexinoid, LG100268, and a selective estrogen receptor modulator, either arzoxifene or acolbifene, synergizes in the prevention and treatment of mammary tumors in an estrogen receptor-negative model of breast cancer. (2006)
- The combination of the rexinoid, LG100268, and a selective estrogen receptor modulator, either arzoxifene or acolbifene, synergizes in the prevention and treatment of mammary tumors in an estrogen receptor-negative model of breast cancer. Clinical Cancer Research (2006)
- Protection against UV-light-induced skin carcinogenesis in SKH-1 high-risk mice by sulforaphane-containing broccoli sprout extracts. (2006)
- Protection against UV-light-induced skin carcinogenesis in SKH-1 high-risk mice by sulforaphane-containing broccoli sprout extracts. Cancer Letters (2006)
- The synthetic triterpenoid CDDO-Imidazolide suppresses STAT phosphorylation and induces apoptosis in myeloma and lung cancer cells. (2006)
- The synthetic triterpenoid CDDO-imidazolide induces monocytic differentiation by activating the Smad and ERK signaling pathways in HL60 leukemia cells. (2006)
- The synthetic triterpenoid CDDO-imidazolide induces monocytic differentiation by activating the Smad and ERK signaling pathways in HL60 leukemia cells. Molecular Cancer Therapeutics (2006)
- Potent protection against aflatoxin-induced tumorigenesis through induction of Nrf2-regulated pathways by the triterpenoid 1-[2-cyano-3-,12-dioxooleana-1,9(11)-dien-28-oyl]imidazole. (2006)
- Potent protection against aflatoxin-induced tumorigenesis through induction of Nrf2-regulated pathways by the triterpenoid 1-[2-cyano-3-,12-dioxooleana-1, 9(11)-dien-28-oyl]imidazole. Cancer Research (2006)
- Cancer chemoprevention: scientific promise, clinical uncertainty. (2005)
- Cancer chemoprevention: Scientific promise, clinical uncertainty. Nature Clinical Practice Oncology (2005)
- The synthetic triterpenoids, CDDO and CDDO-imidazolide, are potent inducers of heme oxygenase-1 and Nrf2/ARE signaling. (2005)
- The synthetic triterpenoids, CDDO and CDDO-imidazolide, are potent inducers of heme oxygenase-1 and Nrf2/ARE signaling. Cancer Research (2005)
- Extremely potent triterpenoid inducers of the phase 2 response: correlations of protection against oxidant and inflammatory stress. (2005)
- Extremely potent triterpenoid inducers of the phase 2 response: Correlations of protection against oxidant and inflammatory stress. Proceedings of the National Academy of Sciences of the United States of America (2005)
- Design, synthesis, and biological evaluation of biotin conjugates of 2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oic acid for the isolation of the protein targets. (2004)
- Design, synthesis, and biological evaluation of biotin conjugates of 2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oic acid for the isolation of the protein targets. Journal of Medicinal Chemistry (2004)
- The selective estrogen receptor modulator arzoxifene and the rexinoid LG100268 cooperate to promote transforming growth factor beta-dependent apoptosis in breast cancer. (2004)
- The selective estrogen receptor modulator arzoxifene and the rexinoid LG100268 cooperate to promote transforming growth factor 13-dependent apoptosis in breast cancer. Cancer Research (2004)
- Prolactin overexpression by MDA-MB-435 human breast cancer cells accelerates tumor growth. (2003)
- Prolactin overexpression by MDA-MB-435 human breast cancer cells accelerates tumor growth. Breast Cancer Research and Treatment (2003)
- Endostatin expression by MDA-MB-435 breast cancer cells effectively inhibits tumor growth. (2003)
- Endostatin expression by MDA-MB-435 breast cancer cells effectively inhibits tumor growth. Cancer Biology and Therapy (2003)
- Prolactin as an autocrine/paracrine growth factor in human cancer. (2002)
- Prolactin as an autocrine/paracrine growth factor in human cancer. Trends in Endocrinology and Metabolism (2002)
- Identification of the human homologue of the early-growth response gene Snk, encoding a serum-inducible kinase. (2001)
- Identification of the human homologue of the early-growth response gene Snk, encoding a serum-inducible kinase. Mitochondrial DNA (2001)
- Proteolysis of human prolactin: resistance to cathepsin D and formation of a nonangiostatic, C-terminal 16K fragment by thrombin. (1999)
- Proteolysis of human prolactin: Resistance to cathepsin D and formation of a nonangiostatic, C-terminal 16K fragment by thrombin. Endocrinology (1999)
- Prolactin as a local growth factor in breast cancer. ()
Employment
- Professor, Indiana University (2023-09-01)