Jonathan Diedrich, PhD
Assistant Professor (fixed-term)
Education
- PhD, Cancer Biology, Wayne State University (2012-08-17—2017-08-17)
- B.S., Zoology, Michigan State University (2008-08-24—2012-06-01)
Funding
- Bone Marrow Adipocytes Alter the Metabolic Phenotype of Metastatic Prostate Cancer , National Cancer Institute (2017—2017)
- Bone Marrow Adipocytes Modulate Tumor Metabolism in Metastatic Prostate Cancer Cells, National Cancer Institute (2015—2017)
- Identification of Cis-Regulatory Elements that Predict ALL Resistance, St. Jude Children's Research Hospital (2017—2017)
- Implifications of AhR modulation by bone marrow adipocytes in multiple myeloma, National Institute of Environmental Health Sciences (2021—2023)
Works
- Investigation of inherited noncoding genetic variation impacting the pharmacogenomics of childhood acute lymphoblastic leukemia treatment. Nature Communications (2024-05-01)
- Epigenomic mapping reveals distinct B cell acute lymphoblastic leukemia chromatin architectures and regulators. Cell Genomics (2023)
- Non-Toxicological Role of Aryl Hydrocarbon Receptor in Obesity-Associated Multiple Myeloma Cell Growth and Survival. Cancers (2023-11-01)
- Adipocyte-derived kynurenine stimulates malignant transformation of mammary epithelial cells through the aryl hydrocarbon receptor. Biochemical Pharmacology (2023)
- Epigenomic mapping in B-cell acute lymphoblastic leukemia identifies transcriptional regulators and noncoding variants promoting distinct chromatin architectures. (2023-02-15)
- Functional investigation of inherited noncoding genetic variation impacting the pharmacogenomics of childhood acute lymphoblastic leukemia treatment. (2023-02-11)
- Epigenomic profiling of glucocorticoid responses identifies cis-regulatory disruptions impacting steroid resistance in childhood acute lymphoblastic leukemia. Leukemia (2022)
- Epigenetic activation of the FLT3 gene by ZNF384 fusion confers a therapeutic susceptibility in acute lymphoblastic leukemia. Nature Communications (2022-09-14)
- Amino acid stress response genes promote L-asparaginase resistance in pediatric acute lymphoblastic leukemia. Blood Advances (2022-06-14)
- Profiling chromatin accessibility in pediatric acute lymphoblastic leukemia identifies subtype-specific chromatin landscapes and gene regulatory networks. Leukemia (2021)
- Genome-Wide Association Study of Susceptibility Loci for TCF3-PBX1 Acute Lymphoblastic Leukemia in Children. JNCI: Journal of the National Cancer Institute (2021-07-01)
- Integrative genomic analyses reveal mechanisms of glucocorticoid resistance in acute lymphoblastic leukemia. Nature Cancer (2020)
- Prostate Tumor Cell–Derived IL1β Induces an Inflammatory Phenotype in Bone Marrow Adipocytes and Reduces Sensitivity to Docetaxel via Lipolysis-Dependent Mechanisms. Molecular Cancer Research (2019-12-01)
- Adipocyte-activated oxidative and ER stress pathways promote tumor survival in bone via upregulation of Heme Oxygenase 1 and Survivin. Scientific Reports (2018)
- The Lipid Side of Bone Marrow Adipocytes: How Tumor Cells Adapt and Survive in Bone. Current Osteoporosis Reports (2018)
- Omentum and bone marrow: how adipocyte-rich organs create tumour microenvironments conducive for metastatic progression. Obesity Reviews (2016)
- Bone marrow adipocytes promote the Warburg phenotype in metastatic prostate tumorsviaHIF-1α activation. Oncotarget (2016-10-04)
- New 3D-Culture Approaches to Study Interactions of Bone Marrow Adipocytes with Metastatic Prostate Cancer Cells. Frontiers in Endocrinology (2016-07-06)
- Adipose tissue dysfunction and its effects on tumor metabolism. Hormone Molecular Biology and Clinical Investigation (2015-01-01)
- Bone-induced c-kit expression in prostate cancer: A driver of intraosseous tumor growth. International Journal of Cancer (2015-01-01)
Employment
- Senior Research Associate, Michigan State University (2021-01-01)
- Postdoctoral Fellow, St. Jude Children's Research Hospital (2017-09-01—2020-11-15)