Andrea Doseff, PhD
Professor
Physiology, Pharmacology & Toxicology
Physiology, Pharmacology & Toxicology
Research
Lab Postdocs
Programs
Education
- Postdoc, , Cold Spring Harbor Laboratory (1996—1998)
- PhD, Genetics, Stony Brook University/Cold Spring Harbor Laboratory (1990—1995)
Works
- Molecular mechanisms underlying gene regulatory variation of maize metabolic traits. The Plant Cell (2024-09-03)
- Transcriptome reprogramming through alternative splicing triggered by apigenin drives cell death in triple-negative breast cancer. Cell Death & Disease (2023-12-13)
- Tart Cherry (Prunus cerasus L.) Pit Extracts Protect Human Skin Cells against Oxidative Stress: Unlocking Sustainable Uses for Food Industry Byproducts. Foods (2023-10-12)
- Tart Cherry (Prunus cerasus L.) Pit Extracts Protect Human Skin Cells against Oxidative Stress: Unlocking Sustainable Uses for Food Industry Byproducts. Foods (2023)
- Role of Heterogeneous Nuclear Ribonucleoproteins in the Cancer-Immune Landscape. International Journal of Molecular Sciences (2023-03-07)
- Arachidin-1, a Prenylated Stilbenoid from Peanut, Enhances the Anticancer Effects of Paclitaxel in Triple-Negative Breast Cancer Cells. Cancers (2023-01-07)
- Use of microfluidic organ-on-a-chip systems for the screening and development of phytopharmaceuticals and herbal drugs. Phytopharmaceuticals and Herbal Drugs: Prospects and Safety Issues in the Delivery of Natural Products (2023)
- Anti-Inflammatory Mechanisms of Dietary Flavones: Tapping into Nature to Control Chronic Inflammation in Obesity and Cancer. International Journal of Molecular Sciences (2022)
- Ibrutinib Blocks YAP1 Activation and Reverses BRAF Inhibitor Resistance in Melanoma Cells. Molecular Pharmacology (2022)
- Bioengineering of Genetically Encoded Gene Promoter Repressed by the Flavonoid Apigenin for Constructing Intracellular Sensor for Molecular Events. Biosensors (2021)
- Bioengineering of genetically encoded gene promoter repressed by the flavonoid apigenin for constructing intracellular sensor for molecular events. Biosensors (2021)
- Splicing reprogramming of TRAIL/DISC-components sensitizes lung cancer cells to TRAIL-mediated apoptosis. Cell Death & Disease (2021-03-17)
- Bioengineering of genetically encoded gene promoter repressed by flavonoids for constructing intracellular sensor for molecular events. (2021-02-18)
- Erratum: Core promoter plasticity between maize tissues and genotypes contrasts with predominance of sharp transcription initiation sites (Plant Cell (2015) 27 (3309-3320) DOI: 10.1105/tpc.15.00630). Plant Cell (2021)
- Apigenin by targeting hnRNPA2 sensitizes triple-negative breast cancer spheroids to doxorubicin-induced apoptosis and regulates expression of ABCC4 and ABCG2 drug efflux transporters. Biochemical Pharmacology (2020)
- Discovery of modules involved in the biosynthesis and regulation of maize phenolic compounds. Plant Science (2020)
- The targeted impact of flavones on obesity-induced inflammation and the potential synergistic role in cancer and the gut microbiota. Molecules (2020)
- Dietary flavonoids for immunoregulation and cancer: Food design for targeting disease. Antioxidants (2019)
- Flavonoids: New frontier for immuno-regulation and breast cancer control. Antioxidants (2019)
- Whole-Genome Multi-omic Study of Survival in Patients with Glioblastoma Multiforme. G3 Genes|Genomes|Genetics (2018-11-01)
- Whole-genome multi-omic study of survival in patients with glioblastoma multiforme. G3: Genes, Genomes, Genetics (2018)
- Genome-wide TSS identification in Maize. Methods in Molecular Biology (2018)
- MicroRNAs targeting caspase-3 and -7 in PANC-1 cells. International Journal of Molecular Sciences (2018)
- A Maize Gene Regulatory Network for Phenolic Metabolism. Molecular Plant (2017)
- Emerging Roles of Flavonoids in Brain Health. Phytopharmaceuticals for Brain Health (2017)
- Lipidomic Adaptations in White and Brown Adipose Tissue in Response to Exercise Demonstrate Molecular Species-Specific Remodeling. Cell Reports (2017)
- Dietary apigenin exerts immune-regulatory activity in vivo by reducing NF-κB activity, halting leukocyte infiltration and restoring normal metabolic function. International Journal of Molecular Sciences (2016)
- Establishing the Architecture of Plant Gene Regulatory Networks. Methods in Enzymology (2016)
- Flavones: From biosynthesis to health benefits. Plants (2016)
- MYB31/MYB42 Syntelogs Exhibit Divergent Regulation of Phenylpropanoid Genes in Maize, Sorghum and Rice. Scientific Reports (2016)
- Core promoter plasticity between maize tissues and genotypes contrasts with predominance of sharp transcription initiation sitesopen. Plant Cell (2015)
- Dietary apigenin reduces LPS-induced expression of miR-155 restoring immune balance during inflammation. Molecular Nutrition and Food Research (2015)
- Distinct contribution of protein kinase Cδ and protein kinase Cε in the lifespan and immune response of human blood monocyte subpopulations. Immunology (2015)
- Flavonoid dietetics: Mechanisms and emerging roles of plant nutraceuticals. Pigments in Fruits and Vegetables (2015)
- Important biological information uncovered in previously unaligned reads from chromatin immunoprecipitation experiments (ChIP-Seq). Scientific Reports (2015)
- Apigenin in combination with Akt inhibition significantly enhances thyrotropin-stimulated radioiodide accumulation in thyroid cells. Thyroid (2014)
- Flavone-rich maize: An opportunity to improve the nutritional value of an important commodity crop. Frontiers in Plant Science (2014)
- The Maize TFome - Development of a transcription factor open reading frame collection for functional genomics. Plant Journal (2014)
- Apigenin protects endothelial cells from lipopolysaccharide (LPS)-induced inflammation by decreasing caspase-3 activation and modulating mitochondrial function. International Journal of Molecular Sciences (2013)
- Chaperone peptides of α-crystallin inhibit epithelial cell apoptosis, protein insolubilization, and opacification in experimental cataracts. Journal of Biological Chemistry (2013)
- Molecular basis for the action of a dietary flavonoid revealed by the comprehensive identi fication of apigenin human targets. Proceedings of the National Academy of Sciences of the United States of America (2013)
- Apigenin induces DNA damage through the PKCδ-dependent activation of ATM and H2AX causing down-regulation of genes involved in cell cycle control and DNA repair. Biochemical Pharmacology (2012)
- Caspase-11 Promotes the Fusion of Phagosomes Harboring Pathogenic Bacteria with Lysosomes by Modulating Actin Polymerization. Immunity (2012)
- Flavone deglycosylation increases their anti-inflammatory activity and absorption. Molecular Nutrition and Food Research (2012)
- Inhibition of ROS-induced apoptosis in endothelial cells by nitrone spin traps via induction of phase II enzymes and suppression of mitochondria- dependent pro-apoptotic signaling. Biochemical Pharmacology (2012)
- Asc-dependent and independent mechanisms contribute to restriction of Legionella pneumophila infection in murine macrophages. Frontiers in Microbiology (2011)
- IL-8-induced neutrophil chemotaxis is mediated by Janus kinase 3 (JAK3). FEBS Letters (2011)
- Apigenin-induced apoptosis of leukemia cells is mediated by a bimodal and differentially regulated residue-specific phosphorylation of heat-shock protein-27. Cell Death and Disease (2010)
- Monocytes and macrophages regulate immunity through dynamic networks of survival and cell death. Journal of Innate Immunity (2010)
- The anti-apoptotic function of human αA-crystallin is directly related to its chaperone activity. Cell Death and Disease (2010)
- The role of heat shock protein 27 in bronchiolitis obliterans syndrome after lung transplantation. Journal of Heart and Lung Transplantation (2010)
- The small heat shock protein 27 is a key regulator of CD8 +CD57+ lymphocyte survival. Journal of Immunology (2010)
- Dysregulation of CD8+ lymphocyte apoptosis, chronic disease, and immune regulation. Frontiers in Bioscience (2009)
- Regulation of monocytes and macrophages cell fate. Frontiers in Bioscience (2009)
- Apigenin blocks lipopolysaccharide-induced lethality in vivo and proinflammatory cytokines expression by inactivating NF-κB through the suppression of p65 phosphorylation. Journal of Immunology (2007)
- Binding of caspase-3 prodomain to heat shock protein 27 regulates monocyte apoptosis by inhibiting caspase-3 proteolytic activation. Journal of Biological Chemistry (2007)
- Apigenin-induced-apoptosis is mediated by the activation of PKCδ and caspases in leukemia cells. Biochemical Pharmacology (2006)
- Keratinocyte growth factor induces Akt kinase activity and inhibits Fas-mediated apoptosis in A549 lung epithelial cells. American Journal of Physiology - Lung Cellular and Molecular Physiology (2005)
- Regulation of monocyte apoptosis by the protein kinase Cδ-dependent phosphorylation of caspase-3. Journal of Biological Chemistry (2005)
- Activated Ets2 is required for persistent inflammatory responses in the motheaten viable model. Journal of Immunology (2004)
- Apoptosis: The sculptor of development. Stem Cells and Development (2004)
- IL-16 is constitutively present in peripheral blood monocytes and spontaneously released during apoptosis. Journal of Immunology (2004)
- Interleukin-4-induced apoptosis entails caspase activation and suppression of extracellular signal-regulated kinase phosphorylation. American Journal of Respiratory Cell and Molecular Biology (2003)
- Presentation of nitric oxide regulates monocyte survival through effects on caspase-9 and caspase-3 activation. Journal of Biological Chemistry (2003)
- 15-Deoxy-Δ12,14-prostaglandin J2 regulates mesangial cell proliferation and death. Kidney International (2002)
- Monocyte survival factors induce Akt activation and suppress caspase-3. American Journal of Respiratory Cell and Molecular Biology (2002)
- Opposing effect by cytokines on Fas-mediated apoptosis in A549 lung epithelial cells. American Journal of Respiratory Cell and Molecular Biology (2002)
- Caspase-3-dependent cleavage of Bcl-2 promotes release of cytochrome c. Journal of Biological Chemistry (1999)
- Macrophage colony-stimulating factor promotes cell survival through Akt/protein kinase B. Journal of Biological Chemistry (1999)
- Spontaneous human monocyte apoptosis utilizes a caspase-3-dependent pathway that is blocked by endotoxin and is independent of caspase-1. Journal of Immunology (1999)
- A two-dimensional, diagonal sodium dodecyl sulfate-polyacrylamide gel electrophoresis technique to screen for protease substrates in protein mixtures. Analytical Biochemistry (1997)
- LAS1 is an essential nuclear protein involved in cell morphogenesis and cell surface growth. Genetics (1995)
- Somatic excision of the Mu1 transposable element of maize. Nucleic Acids Research (1991)
Employment
- Professor, Michigan State University (2017)
- Professor, The Ohio State University (2016—2017)
- Associate Professor, The Ohio State University (2008—2016)
- Assistant Professor , The Ohio State University (2002—2008)
- Research Scientist, The Ohio State University (1998—2002)