Andrea Doseff, PhD

Professor
Physiology, Pharmacology & Toxicology

doseffan@msu.edu

(517) 884-5155

4173 Biological and Physical Sciences Building

Research

Colleges

Programs

Education

Postdoc, , Cold Spring Harbor Laboratory (1996—1998)
PhD, Genetics, Stony Brook University/Cold Spring Harbor Laboratory (1990—1995)

Works

Molecular mechanisms underlying gene regulatory variation of maize metabolic traits. The Plant Cell (2024-06-26)
Transcriptome reprogramming through alternative splicing triggered by apigenin drives cell death in triple-negative breast cancer. Cell Death & Disease (2023-12-13)
Tart Cherry (Prunus cerasus L.) Pit Extracts Protect Human Skin Cells against Oxidative Stress: Unlocking Sustainable Uses for Food Industry Byproducts. Foods (2023-10-12)
Tart Cherry (Prunus cerasus L.) Pit Extracts Protect Human Skin Cells against Oxidative Stress: Unlocking Sustainable Uses for Food Industry Byproducts. Foods (2023)
Role of Heterogeneous Nuclear Ribonucleoproteins in the Cancer-Immune Landscape. International Journal of Molecular Sciences (2023-03-07)
Arachidin-1, a Prenylated Stilbenoid from Peanut, Enhances the Anticancer Effects of Paclitaxel in Triple-Negative Breast Cancer Cells. Cancers (2023-01-07)
Use of microfluidic organ-on-a-chip systems for the screening and development of phytopharmaceuticals and herbal drugs. Phytopharmaceuticals and Herbal Drugs: Prospects and Safety Issues in the Delivery of Natural Products (2023)
Anti-Inflammatory Mechanisms of Dietary Flavones: Tapping into Nature to Control Chronic Inflammation in Obesity and Cancer. International Journal of Molecular Sciences (2022)
Ibrutinib Blocks YAP1 Activation and Reverses BRAF Inhibitor Resistance in Melanoma Cells. Molecular Pharmacology (2022)
Bioengineering of Genetically Encoded Gene Promoter Repressed by the Flavonoid Apigenin for Constructing Intracellular Sensor for Molecular Events. Biosensors (2021)
Bioengineering of genetically encoded gene promoter repressed by the flavonoid apigenin for constructing intracellular sensor for molecular events. Biosensors (2021)
Splicing reprogramming of TRAIL/DISC-components sensitizes lung cancer cells to TRAIL-mediated apoptosis. Cell Death & Disease (2021-03-17)
Bioengineering of genetically encoded gene promoter repressed by flavonoids for constructing intracellular sensor for molecular events. (2021-02-18)
Erratum: Core promoter plasticity between maize tissues and genotypes contrasts with predominance of sharp transcription initiation sites (Plant Cell (2015) 27 (3309-3320) DOI: 10.1105/tpc.15.00630). Plant Cell (2021)
Apigenin by targeting hnRNPA2 sensitizes triple-negative breast cancer spheroids to doxorubicin-induced apoptosis and regulates expression of ABCC4 and ABCG2 drug efflux transporters. Biochemical Pharmacology (2020)
Discovery of modules involved in the biosynthesis and regulation of maize phenolic compounds. Plant Science (2020)
The targeted impact of flavones on obesity-induced inflammation and the potential synergistic role in cancer and the gut microbiota. Molecules (2020)
Dietary flavonoids for immunoregulation and cancer: Food design for targeting disease. Antioxidants (2019)
Flavonoids: New frontier for immuno-regulation and breast cancer control. Antioxidants (2019)
Whole-Genome Multi-omic Study of Survival in Patients with Glioblastoma Multiforme. G3 Genes|Genomes|Genetics (2018-11-01)
Whole-genome multi-omic study of survival in patients with glioblastoma multiforme. G3: Genes, Genomes, Genetics (2018)
Genome-wide TSS identification in Maize. Methods in Molecular Biology (2018)
MicroRNAs targeting caspase-3 and -7 in PANC-1 cells. International Journal of Molecular Sciences (2018)
A Maize Gene Regulatory Network for Phenolic Metabolism. Molecular Plant (2017)
Emerging Roles of Flavonoids in Brain Health. Phytopharmaceuticals for Brain Health (2017)
Lipidomic Adaptations in White and Brown Adipose Tissue in Response to Exercise Demonstrate Molecular Species-Specific Remodeling. Cell Reports (2017)
Dietary apigenin exerts immune-regulatory activity in vivo by reducing NF-κB activity, halting leukocyte infiltration and restoring normal metabolic function. International Journal of Molecular Sciences (2016)
Establishing the Architecture of Plant Gene Regulatory Networks. Methods in Enzymology (2016)
Flavones: From biosynthesis to health benefits. Plants (2016)
MYB31/MYB42 Syntelogs Exhibit Divergent Regulation of Phenylpropanoid Genes in Maize, Sorghum and Rice. Scientific Reports (2016)
Core promoter plasticity between maize tissues and genotypes contrasts with predominance of sharp transcription initiation sitesopen. Plant Cell (2015)
Dietary apigenin reduces LPS-induced expression of miR-155 restoring immune balance during inflammation. Molecular Nutrition and Food Research (2015)
Distinct contribution of protein kinase Cδ and protein kinase Cε in the lifespan and immune response of human blood monocyte subpopulations. Immunology (2015)
Flavonoid dietetics: Mechanisms and emerging roles of plant nutraceuticals. Pigments in Fruits and Vegetables (2015)
Important biological information uncovered in previously unaligned reads from chromatin immunoprecipitation experiments (ChIP-Seq). Scientific Reports (2015)
Apigenin in combination with Akt inhibition significantly enhances thyrotropin-stimulated radioiodide accumulation in thyroid cells. Thyroid (2014)
Flavone-rich maize: An opportunity to improve the nutritional value of an important commodity crop. Frontiers in Plant Science (2014)
The Maize TFome - Development of a transcription factor open reading frame collection for functional genomics. Plant Journal (2014)
Apigenin protects endothelial cells from lipopolysaccharide (LPS)-induced inflammation by decreasing caspase-3 activation and modulating mitochondrial function. International Journal of Molecular Sciences (2013)
Chaperone peptides of α-crystallin inhibit epithelial cell apoptosis, protein insolubilization, and opacification in experimental cataracts. Journal of Biological Chemistry (2013)
Molecular basis for the action of a dietary flavonoid revealed by the comprehensive identi fication of apigenin human targets. Proceedings of the National Academy of Sciences of the United States of America (2013)
Apigenin induces DNA damage through the PKCδ-dependent activation of ATM and H2AX causing down-regulation of genes involved in cell cycle control and DNA repair. Biochemical Pharmacology (2012)
Caspase-11 Promotes the Fusion of Phagosomes Harboring Pathogenic Bacteria with Lysosomes by Modulating Actin Polymerization. Immunity (2012)
Flavone deglycosylation increases their anti-inflammatory activity and absorption. Molecular Nutrition and Food Research (2012)
Inhibition of ROS-induced apoptosis in endothelial cells by nitrone spin traps via induction of phase II enzymes and suppression of mitochondria- dependent pro-apoptotic signaling. Biochemical Pharmacology (2012)
Asc-dependent and independent mechanisms contribute to restriction of Legionella pneumophila infection in murine macrophages. Frontiers in Microbiology (2011)
IL-8-induced neutrophil chemotaxis is mediated by Janus kinase 3 (JAK3). FEBS Letters (2011)
Apigenin-induced apoptosis of leukemia cells is mediated by a bimodal and differentially regulated residue-specific phosphorylation of heat-shock protein-27. Cell Death and Disease (2010)
Monocytes and macrophages regulate immunity through dynamic networks of survival and cell death. Journal of Innate Immunity (2010)
The anti-apoptotic function of human αA-crystallin is directly related to its chaperone activity. Cell Death and Disease (2010)
The role of heat shock protein 27 in bronchiolitis obliterans syndrome after lung transplantation. Journal of Heart and Lung Transplantation (2010)
The small heat shock protein 27 is a key regulator of CD8 ⁺CD57⁺ lymphocyte survival. Journal of Immunology (2010)
Dysregulation of CD8⁺ lymphocyte apoptosis, chronic disease, and immune regulation. Frontiers in Bioscience (2009)
Regulation of monocytes and macrophages cell fate. Frontiers in Bioscience (2009)
Apigenin blocks lipopolysaccharide-induced lethality in vivo and proinflammatory cytokines expression by inactivating NF-κB through the suppression of p65 phosphorylation. Journal of Immunology (2007)
Binding of caspase-3 prodomain to heat shock protein 27 regulates monocyte apoptosis by inhibiting caspase-3 proteolytic activation. Journal of Biological Chemistry (2007)
Apigenin-induced-apoptosis is mediated by the activation of PKCδ and caspases in leukemia cells. Biochemical Pharmacology (2006)
Keratinocyte growth factor induces Akt kinase activity and inhibits Fas-mediated apoptosis in A549 lung epithelial cells. American Journal of Physiology - Lung Cellular and Molecular Physiology (2005)
Regulation of monocyte apoptosis by the protein kinase Cδ-dependent phosphorylation of caspase-3. Journal of Biological Chemistry (2005)
Activated Ets2 is required for persistent inflammatory responses in the motheaten viable model. Journal of Immunology (2004)
Apoptosis: The sculptor of development. Stem Cells and Development (2004)
IL-16 is constitutively present in peripheral blood monocytes and spontaneously released during apoptosis. Journal of Immunology (2004)
Interleukin-4-induced apoptosis entails caspase activation and suppression of extracellular signal-regulated kinase phosphorylation. American Journal of Respiratory Cell and Molecular Biology (2003)
Presentation of nitric oxide regulates monocyte survival through effects on caspase-9 and caspase-3 activation. Journal of Biological Chemistry (2003)
15-Deoxy-Δ¹²,¹⁴-prostaglandin J₂ regulates mesangial cell proliferation and death. Kidney International (2002)
Monocyte survival factors induce Akt activation and suppress caspase-3. American Journal of Respiratory Cell and Molecular Biology (2002)
Opposing effect by cytokines on Fas-mediated apoptosis in A549 lung epithelial cells. American Journal of Respiratory Cell and Molecular Biology (2002)
Caspase-3-dependent cleavage of Bcl-2 promotes release of cytochrome c. Journal of Biological Chemistry (1999)
Macrophage colony-stimulating factor promotes cell survival through Akt/protein kinase B. Journal of Biological Chemistry (1999)
Spontaneous human monocyte apoptosis utilizes a caspase-3-dependent pathway that is blocked by endotoxin and is independent of caspase-1. Journal of Immunology (1999)
A two-dimensional, diagonal sodium dodecyl sulfate-polyacrylamide gel electrophoresis technique to screen for protease substrates in protein mixtures. Analytical Biochemistry (1997)
LAS1 is an essential nuclear protein involved in cell morphogenesis and cell surface growth. Genetics (1995)
Somatic excision of the Mu1 transposable element of maize. Nucleic Acids Research (1991)

Employment

Professor, Michigan State University (2017)
Professor, The Ohio State University (2016—2017)
Associate Professor, The Ohio State University (2008—2016)
Assistant Professor , The Ohio State University (2002—2008)
Research Scientist, The Ohio State University (1998—2002)