Matthew Bernard, PhD
he/his/him
Associate Professor (Fixed-Term) and MSU Flow Cytometry Core Director
Pharmacology and Toxicology
Associate Professor (Fixed-Term) and MSU Flow Cytometry Core Director
Pharmacology and Toxicology
Bio
Matthew Bernard is an Associate Professor in the Department of Pharmacology & Toxicology at Michigan State University. He joined MSU from Bristol-Myers Squibb where he worked as a Senior Research Investigator in Drug Safety Evaluation, performing investigative Immunotoxicology research on small molecules and Biologics. Dr. Bernard is currently the Director of the MSU Flow Cytometry Core Facility. Dr. Bernard obtained his B.S. in Biochemistry at the State University of New York (SUNY) Geneseo. He obtained his Ph.D. in Microbiology & Immunology at the University of Rochester School of Medicine & Dentistry and subsequently worked as a postdoctoral fellow at the La Jolla Institute for Allergy & Immunology (LIAI). He has broad knowledge in designing and conducting applied research studies in Immunopharmacology and Immunotoxicology in a GLP environment. Dr. Bernard has specialized in immunoassay development, validation, and implementation for pharmacology and toxicology endpoints, including having over 20 years of flow cytometry experience. He has extensive experience developing flow cytometric assays and applications, including validating immunophenotyping panels, pharmacodynamic assessments, receptor occupancy evaluation, as well as assays to assess intracellular cytokines, phosphorylated protein expression, transcription factor, proliferation, cell cycle, and viability. As the Director of the MSU Flow Cytometry Core Facility, Dr. Bernard strongly supports the mission of the Core, to provide investigators with access to state-of-the-art cell sorting and analytical flow cytometry services, as well as training and expertise in experimental and data analysis techniques.Research
Colleges
Associations
- MSU Flow Cytometry Core Director
Facilities
- MSU Flow Cytometry Core Facility
Education
- PhD, Immunology & Microbiology, , University of Rochester (2004—2009)
- BS, Biochemistry, , SUNY Geneseo (2000—2004)
Funding
- Acquisition of a Brightfield Imaging Capable Flow Cytometer to Facilitate Agricultural and Environmental Research, National Institute of Food and Agriculture (2022-09-01—2026-08-31)
Works
- Effects of rumen-protected niacin on inflammatory response to repeated intramammary lipopolysaccharide challenges. Journal of Dairy Science (2024)
- Respiration is essential for aerobic growth of Zymomonas mobilis ZM4. mBio (2023-12-19)
- Interleukin-10-producing monocytes contribute to sex differences in pain resolution in mice and humans. (2023-11-05)
- Phosphatidylserine-Exposing Annexin A1-Positive Extracellular Vesicles: Potential Cancer Biomarkers. Vaccines (2023-03-13)
- Evaluation of the Efficacy and Safety of Antiplatelet Therapeutics in Rabbits. Current Protocols (2023)
- Isolation and characterization of uterine leukocytes collected from uterine swab technique. American journal of reproductive immunology (New York, N.Y. : 1989) (2022-08-23)
- Isolation and characterization of uterine leukocytes collected using a uterine swab technique. American Journal of Reproductive Immunology (2022)
- Small Molecule 20S Proteasome Enhancer Regulates MYC Protein Stability and Exhibits Antitumor Activity in Multiple Myeloma. Biomedicines (2022-04-19)
- Small Molecule 20S Proteasome Enhancer Regulates MYC Protein Stability and Exhibits Antitumor Activity in Multiple Myeloma. Biomedicines (2022)
- Phosphatidylserine-exposing medium/large extracellular vesicles: potential cancer biomarkers. bioRxiv (2022)
- In vitro and in vivo analysis of microvesicle-mediated metastasis using a bright, red-shifted bioluminescent reporter protein of extracellular vesicles. bioRxiv (2021)
- Enhancing c-MYC degradation via 20S proteasome activation induces in vivo anti-tumor efficacy. bioRxiv (2020)
- Microvesicle-Mediated Delivery of Minicircle DNA Results in Effective Gene-Directed Enzyme Prodrug Cancer Therapy. Molecular cancer therapeutics (2019-08-26)
- Microvesicle-mediated delivery of minicircle DNA results in effective gene-directed enzyme prodrug cancer therapy. Molecular Cancer Therapeutics (2019)
- DT-678 inhibits platelet activation with lower tendency for bleeding compared to existing P2Y12 antagonists. Pharmacology research & perspectives (2019-07-25)
- DT-678 inhibits platelet activation with lower tendency for bleeding compared to existing P2Y12 antagonists. Pharmacology Research and Perspectives (2019)
- Identifying chemopreventive agents for obesity-associated cancers using an efficient, 3D high-throughput transformation assay. Scientific reports (2019-07-16)
- Identifying chemopreventive agents for obesity-associated cancers using an efficient, 3D high-throughput transformation assay. Scientific Reports (2019)
- Inhibition of cyclooxygenase-2 impairs the expression of essential plasma cell transcription factors and human B-lymphocyte differentiation. Immunology (2010-01-01)
- Inhibition of cyclooxygenase-2 impairs the expression of essential plasma cell transcription factors and human B-lymphocyte differentiation. Immunology (2010)
- Chronic inhibition of cyclooxygenase-2 attenuates antibody responses against vaccinia infection. Vaccine (2009-11-24)
- Chronic inhibition of cyclooxygenase-2 attenuates antibody responses against vaccinia infection. Vaccine (2010)
- Ibuprofen and other widely used non-steroidal anti-inflammatory drugs inhibit antibody production in human cells. Cellular immunology (2009-04-05)
- Ibuprofen and other widely used non-steroidal anti-inflammatory drugs inhibit antibody production in human cells. Cellular Immunology (2009)
- Peroxisome proliferator-activated receptor γ ligands enhance human B cell antibody production and differentiation. Journal of Immunology (2009)
- Targeting cyclooxygenase-2 in hematological malignancies: rationale and promise. Current pharmaceutical design (2008-01-01)
- Targeting cyclooxygenase-2 in hematological malignancies: Rationale and promise. Current Pharmaceutical Design (2008)
- CpG oligodeoxynucleotides induce cyclooxygenase-2 in human B lymphocytes: implications for adjuvant activity and antibody production. Clinical immunology (Orlando, Fla.) (2007-08-28)
- CpG oligodeoxynucleotides induce cyclooxygenase-2 in human B lymphocytes: Implications for adjuvant activity and antibody production. Clinical Immunology (2007)
- Cyclooxygenase-2 inhibition attenuates antibody responses against human papillomavirus-like particles. Journal of Immunology (2006)
- Experimental validation of DNA sequences for DNA computing: Use of a SYBR green I assay. Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics) (2006)
Employment
- Director, Michigan State University (2020)
- Associate Professor, Michigan State University (2015-03-01)
- Research Scientist, MSU In Vivo Facility (2015—2020)
- Senior Research Investigator I, Bristol-Myers Squibb (2011—2015)