Edmund Ellsworth , PhD

Biography

Transforms science into drug candidates and chemical probes. Scientific leader, mentor and program leader with achievements including 11 development candidates. Co-founder of two start-up companies, Management or internal scientists and a of up to >30 internal and external FTEs, enhancing overall productivity 500%, NIH reviewer. Applies technologies, while bringing a sense of urgency, strategic focus, and accountability. A stabilizing influence and a believer of leading by forming partnerships. • Small molecule and peptide therapeutic (antibacterials) drug discovery • Therapeutic area expertise: antibacterials, antivirals, CNS diseases muscle growth, dermal scarring, sexual antagonism, antiparasitics, oncology and inflammation • Target expertise: topoisomerases, kinases, proteases, nuclear hormone receptors, ion channels, ribosome, membrane binding, GPCRs, metalloenzymes, hydrolases, and synthetases • Medicinal chemistry, API process development, and chemoinformatics • Intellectual property development • Early candidate drug development • Structure-based and computer-aided drug design • High throughput screening (HTS), triage including natural product screening • ADME, pharmacokinetics, toxicokinetics • Portfolio management and resourcing • Business development / academic alliances / due diligence including contract negotiations. • Project planning, leadership and budget management • CRO management • NIH, DOD, SBIR/STTR Proposal Development