Ling Huang , PhD

Publications

Abnormal exocrine--endocrine cell cross-talk promotes $β$-cell dysfunction and loss in MODY8 Nature Metabolism (2022)

Organoid Sensitivity Correlates with Therapeutic Response in Patients with Pancreatic Cancer Clinical Cancer Research (2022)

Personalized tumor vaccine for pancreatic cancer Cancer Immunology, Immunotherapy (2022)

Commitment and oncogene-induced plasticity of human stem cell-derived pancreatic acinar and ductal organoids Cell Stem Cell (2021)

Empirical identification and validation of tumor-targeting T cell receptors from circulation using autologous pancreatic tumor organoids Journal for immunotherapy of cancer (2021)

Genome-wide synthetic lethal screen unveils novel CAIX-NFS1/xCT axis as a targetable vulnerability in hypoxic solid tumors Science Advances (2021)

Discovery of New Targets to Control Metastasis in Pancreatic Cancer by Single-cell Transcriptomics Analysis of Circulating Tumor CellsSingle-cell RNA-seq to Uncover Metastatic Targets in PDAC Molecular Cancer Therapeutics (2020)

Discovery of a selective inhibitor of doublecortin like kinase 1 Nature chemical biology (2020)

PDX-derived organoids model in vivo drug response and secrete biomarkers JCI insight (2020)

Synthesis and Structure--Activity Relationships of DCLK1 Kinase Inhibitors Based on a 5, 11-Dihydro-6 H-benzo [e] pyrimido [5, 4-b][1, 4] diazepin-6-one Scaffold Journal of medicinal chemistry (2020)