Masamitsu Kanada , PhD
Biography
My career objective is to become an academic investigator who uses multidisciplinary approaches to address questions in human diseases. I have learned surface chemistry, biochemistry, and molecular and cell biology with expertise in live cell imaging by fluorescence microscopy and whole-body optical preclinical imaging. In addition, with my experience working in a pharmaceutical company, I have gained expertise in drug screening that I brought to my academic appointment. This diverse research background positions me well for building an interdisciplinary research program geared toward the early detection of diseases and developing novel therapeutics. Currently, we are advancing the understanding of EV-mediated intercellular communication and engineering EVs to create targeted gene/drug delivery tools. My research focus is to characterize the ability of EVs to transfer signals to adjacent and distant cells in the body and use this ability to deliver therapy effectively to diseased sites.
Education
Postdoctoral Fellow, Pediatrics, Stanford University School of Medicine, 2012
Ph.D., Cell Biology, University of Tsukuba, 2003
B.S., Biochemical Engineering, Tohoku University, 1999
Employment
Assistant Professor, Michigan State University, East Lansing, 2017 - Present
Publications
Harnessing extracellular vesicles for stabilized and functional IL-10 delivery in macrophage immunomodulation Extracellular Vesicle (2026)
Engineered Peptide Scrambling for Enhanced Drug Delivery to Resistant Breast Cancer Cells via Small Extracellular Vesicles ACS Applied Bio Materials (2025)
Small Extracellular Vesicles Derived from Cord Blood Plasma and Placental Mesenchymal Stem Cells Attenuate Acute Lung Injury Induced by Lipopolysaccharide (LPS) International Journal of Molecular Sciences (2024)
Dynamic reorganization of multivesicular bodies and exosome production impacted by sonoporation Scientific Reports (2024)
Minicircle DNA vectors: A breakthrough in non-viral delivery of CRISPR base editors? Molecular Therapy - Nucleic Acids (2024)
Cyanine lipids promote the shedding of extracellular vesicles from cell membranes Precision Nanomedicine (2023)
Phosphatidylserine-Exposing Annexin A1-Positive Extracellular Vesicles: Potential Cancer Biomarkers Vaccines (2023)
Phosphatidylserine-exposing medium/large extracellular vesicles: potential cancer biomarkers (2022)
Gla-domain mediated targeting of externalized phosphatidylserine for intracellular delivery (2022)