Rance Nault , PhD

he/his/him

Assistant Professor

Pharmacology & Toxicology

naultran@msu.edu

B439 Life Sciences

Biography

The Nault lab's mission is to integrate innovative, emerging, and established methodologies to advance our comprehension of the spatially resolved and cell-specific impacts of chemicals and drugs during the development and progression of liver disease. Through leveraging of innovative experimental techniques and computational approaches, our objective is to gain mechanistic insights into the effects of genetic and environmental factors in the development and progression of disease at an unprecedented level of detail in hopes to support the development of effective personalized strategies to protect human health. More details on our research please go to https://www.rancenault.com/research.

Education

PhD Biochemistry & Molecular Biology and Environmental and Integrative Toxicological Sciences, Biochemistry & Molecular Biology, Michigan State University, 2011
MSc Biology Specialization in Chemical and Environmental Toxicology, Biology, University of Ottawa, 2009

Employment

Assistant Professor, Michigan State University, East Lansing, 2023 - Present
Assistant Professor, Michigan State University, East Lansing, 2021 - 2023

Publications

Loss of Dioxin Response Element-Mediated Induction of PKM2 Reprograms Hepatic Metabolism in Response to TCDD International Journal of Molecular Sciences (2025)

Isomer-specific distribution of perfluorooctane sulfonate (PFOS) in hepatic zonation in mouse (2025)

Application of a metabolic network-based graph neural network for the identification of toxicant-induced perturbations Toxicological Sciences (2025)

Omega-3 Fatty Acid Synergy with Glucocorticoid in Lupus Macrophages: Targeting Pathogenic Pathways to Reduce Steroid Dependence (2025)

Mechanotransduction in the Perivascular Adipose Tissue Arteriosclerosis, Thrombosis, and Vascular Biology (2025)

Single-nucleus analysis of thoracic perivascular adipose tissue reveals critical changes in cell composition, communication, and gene regulatory networks induced by a high fat hypertensive diet (2025)

2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) elicited dose-dependent shifts in the murine urinary metabolome associated with hepatic AHR-mediated differential gene expression (2024)

Early life adversity promotes gastrointestinal dysfunction through a sex-dependent phenotypic switch in enteric glia (2024)

A cell atlas of thoracic aortic perivascular adipose tissue: a focus on mechanotransducers American Journal of Physiology-Heart and Circulatory Physiology (2024)

Adipocyte stem and progenitor cell subpopulation proportions. (2024)

In the News

Rance Nault

Rance Nault Brings His Love of Research to a Department He Knows Well

Assistant Professor Rance Nault has worked as a researcher at MSU for more than a decade, but recently he became a full-fledged faculty member studying chemical and environmental toxicology