Adrianne Wallace-Povirk , PhD

Publications

Mitochondrial and Cytosolic One-Carbon Metabolism Is a Targetable Metabolic Vulnerability in Cisplatin-Resistant Ovarian Cancer Molecular Cancer Therapeutics (2024)

Structure-Based Design of Transport-Specific Multitargeted One-Carbon Metabolism Inhibitors in Cytosol and Mitochondria Journal of Medicinal Chemistry (2023)

Sirtuin 6 is required for the integrated stress response and resistance to inhibition of transcriptional cyclin-dependent kinases Science Translational Medicine (2023)

Targeted therapy of pyrrolo[2,3-d]pyrimidine antifolates in a syngeneic mouse model of high grade serous ovarian cancer and the impact on the tumor microenvironment. Scientific reports (2022)

Folate transporter dynamics and therapy with classic and tumor-targeted antifolates Scientific Reports (2021)

Discovery of 6-substituted thieno[2,3-d]pyrimidine analogs as dual inhibitors of glycinamide ribonucleotide formyltransferase and 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase in de novo purine nucleotide biosynthesis in folate receptor expressing human tumors. Bioorganic & medicinal chemistry (2021)

Folate Transport and One-Carbon Metabolism in Targeted Therapies of Epithelial Ovarian Cancer Cancers (2021)

Targeting one-carbon metabolism in syngeneic mouse model of BRCA-mutated high-grade serous ovarian cancer Gynecologic Oncology (2020)

Cellular Pharmacodynamics of a Novel Pyrrolo[3,2-d]pyrimidine Inhibitor Targeting Mitochondrial and Cytosolic One-Carbon Metabolism Molecular Pharmacology (2020)

Abstract 2992: Cellular pharmacodynamics of mitochondrial one-carbon metabolism-targeting 5-substituted pyrrolo[3,2-d]pyrimidine antifolates Experimental and Molecular Therapeutics (2019)