Cheryl Rockwell, PhD
Associate Professor
Pharmacology & Toxicology
Pharmacology & Toxicology
Research
Lab Staff
Mentees
Programs
Sections
- PHM 801 Fundamental Principles of Pharmacology and Toxicology (in-person) - Fall
- PHM 803 Chemical Disposition in Mammals (in-person) - Fall
- PHM 805 Receptor Pharmacology (in-person) - Fall
- PHM 802 Cellular, Molecular and Integrated Systems Pharmacology (in-person) - Spring
- PHM 816 Integrative Toxicology: Mechanisms, Pathology and Regulation (in-person) - Fall Odd Years
Works
- A cell atlas of thoracic aortic perivascular adipose tissue: a focus on mechanotransducers. American Journal of Physiology-Heart and Circulatory Physiology (2024-05-01)
- A Cell Atlas of Thoracic Aortic Perivascular Adipose Tissue: a focus on mechanotransducers. (2023-10-09)
- Trivalent arsenic impairs the effector response of human CD4+ and CD8+ T cells to influenza A virus ex vivo. Food and Chemical Toxicology (2022)
- Chronic low-level cadmium exposure in rats affects cytokine production by activated T cells. Toxicology Research (2019)
- Differential Sensitivity of Kupffer Cells and Hepatic Monocyte-Derived Macrophages to Bacterial Lipopolysaccharide. Clin Exp Gastroenterol Hepatol (2019)
- Comparison of Hepatic NRF2 and Aryl Hydrocarbon Receptor Binding in 2,3,7,8-Tetrachlorodibenzo-p-dioxin-Treated Mice Demonstrates NRF2-Independent PKM2 Induction. Mol Pharmacol (2018)
- Differential effects of the Nrf2 activators tBHQ and CDDO-Im on the early events of T cell activation. Biochem Pharmacol (2018)
- Identification of an Unfavorable Immune Signature in Advanced Lung Tumors from Nrf2-Deficient Mice. Antioxid Redox Signal (2018)
- The Nrf2 activator tBHQ inhibits the activation of primary murine natural killer cells. Food Chem Toxicol (2018)
- Inhibition of early T cell cytokine production by arsenic trioxide occurs independently of Nrf2. PLoS One (2017)
- Nrf2-Dependent and -Independent Effects of tert-Butylhydroquinone, CDDO- Im, and H2O2 in Human Jurkat T Cells as Determined by CRISPR/Cas9 Gene Editing. J Pharmacol Exp Ther (2017)
- Persistent alterations in immune cell populations and function from a single dose of perfluorononanoic acid (PFNA) in C57Bl/6 mice. Food Chem Toxicol (2017)
- Pharmacological Inhibition of Myocardin-related Transcription Factor Pathway Blocks Lung Metastases of RhoC-Overexpressing Melanoma. Mol Cancer Ther (2017)
- Fibrin deposition following bile duct injury limits fibrosis through an alphaMbeta2-dependent mechanism. Blood (2016)
- Individual bile acids have differential effects on bile acid signaling in mice. Toxicol Appl Pharmacol (2015)
- The Nrf2 activator tBHQ inhibits T cell activation of primary human CD4 T cells. Cytokine (2015)
- Enhanced allergic airway disease in old mice is associated with a Th17 response. Clin Exp Allergy (2014)
- Fas-induced apoptosis increases hepatocyte tissue factor procoagulant activity in vitro and in vivo. Toxicol Sci (2014)
- Hepatic stellate cells orchestrate clearance of necrotic cells in a hypoxia-inducible factor-1alpha-dependent manner by modulating macrophage phenotype in mice. J Immunol (2014)
- Acute Immunotoxic Effects of Perfluorononanoic Acid (PFNA) in C57BL/6 Mice. Clin Exp Pharmacol (2013)
- Hepatocyte tissue factor activates the coagulation cascade in mice. Blood (2013)
- IL-17A synergistically enhances bile acid-induced inflammation during obstructive cholestasis. Am J Pathol (2013)
- The Nrf2 activator, tBHQ, differentially affects early events following stimulation of Jurkat cells. Toxicol Sci (2013)
- A critical role for the inducible proteasomal subunits LMP7 and MECL1 in cytokine production by activated murine splenocytes. Pharmacology (2012)
- Effect of bile duct ligation on bile acid composition in mouse serum and liver. Liver Int (2012)
- Th2 skewing by activation of Nrf2 in CD4(+) T cells. J Immunol (2012)
- Protease-activated receptor 1 and hematopoietic cell tissue factor are required for hepatic steatosis in mice fed a Western diet. Am J Pathol (2011)
- ChIPing the cistrome of PXR in mouse liver. Nucleic Acids Res (2010)
- Differential effects of lactacystin on cytokine production in activated Jurkat cells and murine splenocytes. Cytokine (2010)
- Lipid A-mediated tolerance and cancer therapy. Adv Exp Med Biol (2010)
- Transcriptional regulation of renal cytoprotective genes by Nrf2 and its potential use as a therapeutic target to mitigate cisplatin-induced nephrotoxicity. J Pharmacol Exp Ther (2010)
- A COX-2 metabolite of the endogenous cannabinoid, 2-arachidonyl glycerol, mediates suppression of IL-2 secretion in activated Jurkat T cells. Biochem Pharmacol (2008)
- A combination of proteasome inhibitors and antibiotics prevents lethality in a septic shock model. Innate Immun (2008)
- Interleukin-2 suppression by 2-arachidonyl glycerol is mediated through peroxisome proliferator-activated receptor gamma independently of cannabinoid receptors 1 and 2. Mol Pharmacol (2006)
- 2-Arachidonoyl-glycerol suppresses interferon-gamma production in phorbol ester/ionomycin-activated mouse splenocytes independent of CB1 or CB2. J Leukoc Biol (2005)
- A cyclooxygenase metabolite of anandamide causes inhibition of interleukin-2 secretion in murine splenocytes. J Pharmacol Exp Ther (2004)
- Evidence for cannabinoid receptor-dependent and -independent mechanisms of action in leukocytes. J Pharmacol Exp Ther (2003)
Employment
- Associate Professor, Michigan State University (2017-07-01)
- Assistant Professor, Michigan State University (2011-09-15—2017-06-30)