Kari Sant, PhD
she/her/hers
Associate Professor
Pharmacology & Toxicology
Associate Professor
Pharmacology & Toxicology
Lab Postdocs
Colleges
Programs
Education
- Doctor of Philosophy, Environmental Health Sciences, University of Michigan (2010-09-01—2014-12-15)
- Master of Public Health, Environmental Health Sciences, University of Michigan (2008-09-01—2010-05-01)
- Bachelor of Science, Biology, Program in the Environment, University of Michigan (2003-09-01—2008-05-01)
Funding
- Assessing Fate and Toxicity of Microplastics under Coastal Environment Conditions, Council on Ocean Affairs Science and Technology, California State University (2021—2022)
- Global Centers: International Research Center for Enhancing Plant Resilience, Office of the Director (2025-01-01—2029-12-31)
- Integrating Computational and Experimental Models to Predict Toxicity of the Pancreas, National Institute of Diabetes and Digestive and Kidney Diseases (2023-02-15—2025-12-31)
- Interactions between PPAR, embryonic nutrition, and the developmental origins of metabolic dysfunction, National Institute of Environmental Health Sciences (2017-05-15—2020-05-14)
- Elucidating the role of PPAR signaling in pancreatic organogenesis and juvenile metabolic syndrome, National Institute of Environmental Health Sciences (2020-08-06—2023-07-31)
- Toxicant disruption of receptor-mediated endocytosis in oogenesis and later life metabolic dysfunction, National Institute of Environmental Health Sciences (2017-09-01—2022-08-31)
- Sunlight and tire wear particles - a toxic combination? Evaluating mechanisms for mobilization and degradation of tire particle compounds, Directorate for Engineering (2023-09-01—2026-08-31)
- RP-Sant/Quintana: Assessment of Exposure to Microbial and Chemical Pollution in US Community Air from the Binational Tijuana River Watershed, National Institute on Minority Health and Health Disparities (2024—2029)
- Hazard assessment of deep ocean DDT disposal: Defining biomagnified DDT+ chemical profiles and investigating the health impacts on sentinel wildlife species and humans, University of Southern California Sea Grant (2023—2025)
- Environmental Toxicity of Electronic Cigarette and Heated Tobacco Product Components and Waste, California Tobacco Related Disease Research Program (2022—2024)
- Surface Water Emissions from Cannabis Cultivation Sites: Quantity, Quality, Toxicity, and Relationships to Farmers' Practices, California Department of Cannabis Control (2021—2023)
Works
- Behavior of compounds leached from tire tread particles under simulated sunlight exposure. Water Research (2025)
- Reproductive toxicity of DDT in the Japanese medaka fish model: Revisiting the impacts of DDT+ on female reproductive health. Chemosphere (2024)
- Novel chemical contaminants associated with thirdhand smoke in settled house dust. Chemosphere (2024)
- Metagenomic analysis of microbial communities and antibiotic resistant genes in the Tijuana river, and potential sources. Environmental Pollution (2024)
- Development of a Dynamic Network Model to Identify Temporal Patterns of Structural Malformations in Zebrafish Embryos Exposed to a Model Toxicant, Tris(4-chlorophenyl)methanol. Journal of Xenobiotics (2023-06-16)
- The Influence of Cannabinoids on Drosophila Behaviors, Longevity, and Traumatic Injury Responses of the Adult Nervous System. Cannabis and cannabinoid research (2023)
- Tris(4‐chlorophenyl)methane and tris(4‐chlorophenyl)methanol disrupt pancreatic organogenesis and gene expression in zebrafish embryos. Birth Defects Research (2023)
- Metagenomic Analysis of Microbial Contamination in the U.S. Portion of the Tijuana River Watershed. International Journal of Environmental Research and Public Health (2022-12-29)
- Detection, Quantification, and Simplified Wastewater Surveillance Model of SARS-CoV-2 RNA in the Tijuana River. ACS ES&T Water (2022-11-11)
- Association between particulate matter air pollution and heart attacks in San Diego County. Journal of the Air & Waste Management Association (2021-12-02)
- Associations between Exposures to Perfluoroalkyl Substances and Diabetes, Hyperglycemia, or Insulin Resistance: A Scoping Review. Journal of Xenobiotics (2021-09-14)
- The Role of Diversity, Equity, and Inclusion in the Future of Toxicology. Toxicological Sciences (2021-08-03)
- Modulation of PPAR signaling disrupts pancreas development in the zebrafish, Danio rerio. Toxicology and applied pharmacology (2021)
- Mathematical modeling of the interaction between yolk utilization and fish growth in zebrafish, Danio rerio. Development (2021-05-01)
- Developmental exposures to perfluorooctanesulfonic acid (PFOS) impact embryonic nutrition, pancreatic morphology, and adiposity in the zebrafish, Danio rerio. Environmental Pollution (2021)
- Maternal preconception PFOS exposure of Drosophila melanogaster alters reproductive capacity, development, morphology and nutrient regulation. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association (2021)
- The ecotoxicological contaminant tris(4-chlorophenyl)methanol (TCPMOH) impacts embryonic development in zebrafish (Danio rerio). Aquatic toxicology (Amsterdam, Netherlands) (2021)
- Embryonic exposures to mono-2-ethylhexyl phthalate induce larval steatosis in zebrafish independent of Nrf2a signaling. Journal of Developmental Origins of Health and Disease (2021-02-17)
- The emerging contaminant 3,3'-dichlorobiphenyl (PCB-11) impedes Ahr activation and Cyp1a activity to modify embryotoxicity of Ahr ligands in the zebrafish embryo model (Danio rerio). Environmental pollution (Barking, Essex : 1987) (2019-08-06)
- The emerging contaminant 3,3″-dichlorobiphenyl (PCB-11) impedes Ahr activation and Cyp1a activity to modify embryotoxicity of Ahr ligands in the zebrafish embryo model (Danio rerio). Environmental Pollution (2019)
- Perfluorobutanesulfonic Acid Disrupts Pancreatic Organogenesis and Regulation of Lipid Metabolism in the Zebrafish, Danio rerio. Toxicological Sciences (2019-01-01)
- Perfluorobutanesulfonic acid disrupts pancreatic organogenesis and regulation of lipid metabolism in the Zebrafish, Danio rerio. Toxicological Sciences (2019)
- Embryonic exposure to Mono(2-ethylhexyl) phthalate (MEHP) disrupts pancreatic organogenesis in zebrafish (Danio rerio). Chemosphere (2018)
- Zebrafish as a Model for Toxicological Perturbation of Yolk and Nutrition in the Early Embryo. Current Environmental Health Reports (2018-02-07)
- Nrf2a Modulates the Embryonic Antioxidant Response to Perfluorooctanesulfonic Acid (PFOS) in the Zebrafish, Danio rerio. Aquatic Toxicology (2018)
- Nrf2a modulates the embryonic antioxidant response to perfluorooctanesulfonic acid (PFOS) in the zebrafish, Danio rerio. Aquatic Toxicology (2018)
- Fumonisin, Folate and other Methyl Donors and Neural Tube Defects. Comprehensive Toxicology: Third Edition (2018)
- Methods for analysis of DNA methylation. Toxicoepigenetics: Core Principles and Applications (2018)
- Pancreatic beta cells are a sensitive target of embryonic exposure to butylparaben in zebrafish (Danio rerio). Birth Defects Research (2018)
- The role of Nrf1 and Nrf2 in the regulation of glutathione and redox dynamics in the developing zebrafish embryo. Redox biology (2017)
- The role of Nrf1 and Nrf2 in the regulation of glutathione and redox dynamics in the developing zebrafish embryo. Redox Biology (2017)
- Novel Epigenetic Biomarkers Mediating Bisphenol A Exposure and Metabolic Phenotypes in Female Mice. Endocrinology (2016-11-08)
- Novel epigenetic biomarkers mediating bisphenol a exposure and metabolic phenotypes in female mice. Endocrinology (2017)
- Embryonic exposures to perfluorooctanesulfonic acid (PFOS) disrupt pancreatic organogenesis in the zebrafish, Danio rerio. Environmental Pollution (2016-10-31)
- Assessment of Toxicological Perturbations and Variants of Pancreatic Islet Development in the Zebrafish Model. Toxics (2016)
- Assessment of toxicological perturbations and variants of pancreatic islet development in the Zebrafish model. Toxics (2016)
- Epigenome-wide DNA methylation analysis implicates neuronal and inflammatory signaling pathways in adult murine hepatic tumorigenesis following perinatal exposure to bisphenol A. (2016)
- Epigenome-wide DNA methylation analysis implicates neuronal and inflammatory signaling pathways in adult murine hepatic tumorigenesis following perinatal exposure to bisphenol A. Environmental and Molecular Mutagenesis (2016)
- Mono-2-ethylhexyl phthalate disrupts neurulation and modifies the embryonic redox environment and gene expression. Reproductive Toxicology (2016-05-07)
- Deviant development of pancreatic beta cells from embryonic exposure to PCB-126 in zebrafish. Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology (2015-09-21)
- Mono-2-ethylhexyl phthalate (MEHP) alters histiotrophic nutrition pathways and epigenetic processes in the developing conceptus. (2015)
- Mono-2-ethylhexyl phthalate (MEHP) alters histiotrophic nutrition pathways and epigenetic processes in the developing conceptus. Journal of Nutritional Biochemistry (2016)
- Regulation of Ahr signaling by Nrf2 during development: Effects of Nrf2a deficiency on PCB126 embryotoxicity in zebrafish (Danio rerio). Aquatic Toxicology (2015-08-13)
- Amino Acid Starvation Induced by Protease Inhibition Produces Differential Alterations in Redox Status and the Thiol Proteome in Organogenesis-Stage Rat Embryos and Visceral Yolk Sacs. Journal of Nutritional Biochemistry (2015-08-11)
- Amino acid starvation induced by protease inhibition produces differential alterations in redox status and the thiol proteome in organogenesis-stage rat embryos and visceral yolk sacs. Journal of Nutritional Biochemistry (2015)
- Ethanol Attenuates Histiotrophic Nutrition Pathways and Alters the Intracellular Redox Environment and Thiol Proteome during Rat Organogenesis. (2015)
- Ethanol attenuates histiotrophic nutrition pathways and alters the intracellular redox environment and thiol proteome during rat organogenesis. Toxicological Sciences (2015)
- Inhibition of glutathione biosynthesis alters compartmental redox status and the thiol proteome in organogenesis-stage rat conceptuses. (2013)
- Inhibition of glutathione biosynthesis alters compartmental redox status and the thiol proteome in organogenesis-stage rat conceptuses. Free Radical Biology and Medicine (2013)
- Inhibition of proteolysis in histiotrophic nutrition pathways alters DNA methylation and one-carbon metabolism in the organogenesis-stage rat conceptus. (2013)
- Inhibition of proteolysis in histiotrophic nutrition pathways alters DNA methylation and one-carbon metabolism in the organogenesis-stage rat conceptus. Journal of Nutritional Biochemistry (2013)
- Nutrition and epigenetics: an interplay of dietary methyl donors, one-carbon metabolism and DNA methylation. (2012)
- Nutrition and epigenetics: An interplay of dietary methyl donors, one-carbon metabolism and DNA methylation. Journal of Nutritional Biochemistry (2012)
- DNA methylation screening and analysis. (2012)
- DNA methylation screening and analysis. Methods in Molecular Biology (2012)
Employment
- Associate Professor, Michigan State University (2024-08-16)
- Associate Professor of Environmental Health, San Diego State University (2022-08-20—2024-08-14)
- Assistant Professor of Environmental Health, San Diego State University (2018-08-16—2022-08-19)
- Postdoctoral Research Fellow, University of Massachusetts Amherst (2015-01-05—2018-08-15)