James P. Luyendyk, Ph.D.

  • Drug Discovery and Receptor Faculty, Environmental Faculty, Immunopharmacology Faculty

Associate Professor,
Pharmacology & Toxicology

Institute for Integrative Toxicology

253 Food Safety
1129 Farm Lane
East Lansing, MI 48823

Email: luyendyk@msu.edu

Phone: (517) 884-2057 | Fax: (517) 432-3218 | Location:  253 Food Safety

Fields of Interest: Elucidation of the molecular mechanisms for impairment of signal transduction cascades and gene expression during lymphocyte activation by drugs and chemicals; mechanism for immune modulation by cannabinoid compounds

  • 2000 - B.S., Biochemistry - Colorado State University
  • 2004 - Ph.D., Pharmacology & Toxicology-Environmental Toxicology,
    Michigan State University

Research Synopsis:

Our research focus is at the intersection of blood coagulation and liver toxicity/disease. Our long term goal is to understand the mechanisms linking the coagulation cascade to liver injury and disease, and reciprocally, to define mechanisms whereby liver damage affects coagulation activity.

Within this central theme, the team in the laboratory is exploring the mechanisms linking various components of the hemostatic system, including specific coagulation factors, to acute liver injury and liver repair, hepatic fibrosis, autoimmune-mediated liver diseases, and obesity-associated sequelae including non-alcoholic fatty liver diseases. Graduate students and post-doctoral fellows are defining mechanisms driving these processes. Our research capitalizes on our expertise in numerous fields, including hepatology, hematology, investigative pathology and toxicology and the involvement of coagulation factors in liver pathology driven by drugs and environmental chemical exposures is embedded within our central research theme.