James P. Luyendyk, Ph.D.
Pharmacology & Toxicology
Institute for Integrative Toxicology
253 Food Safety
1129 Farm Lane
East Lansing, MI 48823
Fields of Interest: The liver synthesizes numerous coagulation factors, making altered hemostasis a significant concern in patients with end-stage liver disease. Our laboratory approaches this connection early in the pathogenesis of liver disease. The team’s long-term goal is to understand the mechanisms whereby the coagulation cascade contributes to the pathogenesis of liver disease.
- 2000 - B.S., Biochemistry - Colorado State University
- 2004 - Ph.D., Pharmacology & Toxicology-Environmental Toxicology,
Michigan State University
Our research focus is at the intersection of blood coagulation and liver toxicity/disease. Our long term goal is to understand the mechanisms linking the coagulation cascade to liver injury and disease, and reciprocally, to define mechanisms whereby liver damage affects coagulation activity.
Within this central theme, the team in the laboratory is exploring the mechanisms linking various components of the hemostatic system, including specific coagulation factors, to acute liver injury and liver repair, hepatic fibrosis, autoimmune-mediated liver diseases, and obesity-associated sequelae including non-alcoholic fatty liver diseases. Graduate students and post-doctoral fellows are defining mechanisms driving these processes. Our research capitalizes on our expertise in numerous fields, including hepatology, hematology, investigative pathology and toxicology and the involvement of coagulation factors in liver pathology driven by drugs and environmental chemical exposures is embedded within our central research theme.
- Coagulation-driven platelet activation reduces cholestatic liver injury and fibrosis in mice.
Joshi N, Kopec AK, O'Brien KM, Towery KL, Cline-Fedewa H, Williams KJ, Copple BL, Flick MJ, Luyendyk JP. J Thromb Haemost. 2015 Jan;13(1):57-71.
Toxicogenomic analysis reveals profibrogenic effects of trichloroethylene in autoimmune-mediated cholangitis in mice.
Kopec AK, Sullivan BP, Kassel KM, Joshi N, Luyendyk JP. Toxicol Sci. 2014 Oct 1;141(2):515-23.
Fas-induced apoptosis increases hepatocyte tissue factor procoagulant activity in vitro and in vivo.
Lopez M, Kopec AK, Joshi N, Geddings JE, Cline H, Towery KL, Rockwell CE, Mackman N, Luyendyk JP. Toxicol Sci. 2014 Oct 1;141(2):453-64.