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James P. Luyendyk, Ph.D.

Professor, Pharmacology & Toxicology
Institute for Integrative Toxicology

253 Food Safety
1129 Farm Lane
East Lansing, MI 48823

Email: luyendyk@msu.edu

Phone: (517) 884-2057 | Fax: (517) 432-3218 | Location:  253 Food Safety

Fields of Interest: The liver synthesizes numerous coagulation factors, making altered hemostasis a significant concern in patients with end-stage liver disease. Our laboratory approaches this connection early in the pathogenesis of liver disease. The team’s long-term goal is to understand the mechanisms whereby the coagulation cascade contributes to the pathogenesis of liver disease.

  • 2000 - B.S., Biochemistry - Colorado State University
  • 2004 - Ph.D., Pharmacology & Toxicology-Environmental Toxicology,
    Michigan State University

Research Synopsis:

Our research focus is at the intersection of blood coagulation and liver toxicity/disease. Our long term goal is to understand the mechanisms linking the coagulation cascade to liver injury and disease, and reciprocally, to define mechanisms whereby liver damage affects coagulation activity.

Within this central theme, the team in the laboratory is exploring the mechanisms linking various components of the hemostatic system, including specific coagulation factors, to acute liver injury and liver repair, hepatic fibrosis, autoimmune-mediated liver diseases, and obesity-associated sequelae including non-alcoholic fatty liver diseases. Graduate students and post-doctoral fellows are defining mechanisms driving these processes. Our research capitalizes on our expertise in numerous fields, including hepatology, hematology, investigative pathology and toxicology and the involvement of coagulation factors in liver pathology driven by drugs and environmental chemical exposures is embedded within our central research theme.