Rance Nault, PhD

he/his/him
Assistant Professor
Pharmacology & Toxicology

Bio

My lab explores the influence of individual cell types and spatial organization on metabolic disease progression utilizing both cutting-edge technologies and traditional methodologies. Our goal is to reveal the intricate interplay between environmental factors and the specific characteristics of cells and their locations.

Colleges

• College of Osteopathic Medicine

Programs

• Doctor of Philosophy in Pharmacology and Toxicology

Education

• PhD Biochemistry & Molecular Biology and Environmental and Integrative Toxicological Sciences, Biochemistry & Molecular Biology, Michigan State University (2011—2016)
• MSc Biology Specialization in Chemical and Environmental Toxicology, Biology, University of Ottawa (2009—2011)

Works

• 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) elicited dose-dependent shifts in the murine urinary metabolome associated with hepatic AHR-mediated differential gene expression. (2024-10-25)
• Early life adversity promotes gastrointestinal dysfunction through a sex-dependent phenotypic switch in enteric glia. (2024-06-03)
• A cell atlas of thoracic aortic perivascular adipose tissue: a focus on mechanotransducers. American Journal of Physiology-Heart and Circulatory Physiology (2024-05-01)
• Adipocyte stem and progenitor cell subpopulation proportions. (2024-03-18)
• Expression of transient protein channels in taPVAT and BAT. (2024-03-18)
• Gene ontology term definitions and membership. (2024-03-18)
• Piezo1 RNAscope analysis of taPVAT from female Dahl SS rats. (2024-03-18)
• Re-integration and clustering of adipocytes. (2024-03-18)
• Re-integration and clustering of immune cells. (2024-03-18)
• Table of key resources. (2024-03-18)
• UMAP clustering and cell annotation of Leiden clusters. (2024-03-18)
• How single-cell transcriptomics provides insight on hepatic responses to TCDD. Current Opinion in Toxicology (2023)
• A Cell Atlas of Thoracic Aortic Perivascular Adipose Tissue: a focus on mechanotransducers. (2023-10-09)
• Cystine/Glutamate Xc– Antiporter Induction Compensates for Transsulfuration Pathway Repression by 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) to Ensure Cysteine for Hepatic Glutathione Biosynthesis. Chemical Research in Toxicology (2023-06-19)
• A Case for Accelerating Standards to Achieve the FAIR Principles of Environmental Health Research Experimental Data. Environmental Health Perspectives (2023)
• Analysis of Cell–Cell Communication by Single-Nuclei RNA Sequencing Identifies AHR-Mediated Induction of NRG-ERBB Signaling. Receptors (2023-05-11)
• Single-cell transcriptomics shows dose-dependent disruption of hepatic zonation by TCDD in mice. Toxicological Sciences (2023-01-31)
• Generative Modeling of Single Cell Gene Expression for Dose-Dependent Chemical Perturbations. (2022-10-07)
• Dose-dependent disruption of hepatic zonation by 2,3,7,8-tetrachlorodibenzo-p-dioxin in mice: integration of single-nuclei RNA sequencing and spatial transcriptomics. (2022-06-17)
• Benchmarking of a Bayesian single cell RNAseq differential gene expression test for dose–response study designs. Nucleic Acids Research (2022-05-06)
• Genome-Wide ChIPseq Analysis of AhR, COUP-TF, and HNF4 Enrichment in TCDD-Treated Mouse Liver. International Journal of Molecular Sciences (2022-01-29)
• Benchmarking of a Bayesian single cell RNAseq differential gene expression test for dose-response study designs. (2021-09-10)
• Single-Nuclei RNA Sequencing Assessment of the Hepatic Effects of 2,3,7,8-Tetrachlorodibenzo-p-dioxin. Cellular and Molecular Gastroenterology and Hepatology (2021)
• Genetics-Based Approach to Identify Novel Genes Regulated by the Aryl Hydrocarbon Receptor in Mouse Liver. Toxicological Sciences (2021-05-27)
• 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) alters hepatic polyunsaturated fatty acid metabolism and eicosanoid biosynthesis in female Sprague-Dawley rats. Toxicology and Applied Pharmacology (2020)
• Application of single nuclei RNA sequencing to assess the hepatic effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin. (2020-04-08)
• A toxicogenomic approach for the risk assessment of the food contaminant acetamide. Toxicology and Applied Pharmacology (2020)
• 2,3,7,8-Tetrachlorodibenzo-p-dioxin dose-dependently increases bone mass and decreases marrow adiposity in juvenile mice. Toxicology and Applied Pharmacology (2018)
• Loss of liver-specific and sexually dimorphic gene expression by aryl hydrocarbon receptor activation in C57BL/6 mice. PLOS ONE (2017-09-18)
• Lipidomic Evaluation of Aryl Hydrocarbon Receptor-Mediated Hepatic Steatosis in Male and Female Mice Elicited by 2,3,7,8-Tetrachlorodibenzo-p-dioxin. Chemical Research in Toxicology (2017-04-17)

Employment

• Assistant Professor, Michigan State University (2023-11-01)
• Assistant Professor, Michigan State University (2021-01-01—2023-10-31)