Rance Nault, PhD

he/his/him
Assistant Professor
Pharmacology & Toxicology

Bio

The Nault lab's mission is to integrate innovative, emerging, and established methodologies to advance our comprehension of the spatially resolved and cell-specific impacts of chemicals and drugs during the development and progression of liver disease. Through leveraging of innovative experimental techniques and computational approaches, our objective is to gain mechanistic insights into the effects of genetic and environmental factors in the development and progression of disease at an unprecedented level of detail in hopes to support the development of effective personalized strategies to protect human health. More details on our research please go to https://www.rancenault.com/research.

Colleges

• College of Osteopathic Medicine

Programs

• Doctor of Philosophy in Pharmacology and Toxicology

Education

• PhD Biochemistry & Molecular Biology and Environmental and Integrative Toxicological Sciences, Biochemistry & Molecular Biology, Michigan State University (2011—2016)
• MSc Biology Specialization in Chemical and Environmental Toxicology, Biology, University of Ottawa (2009—2011)

Works

• Single-nucleus analysis of thoracic perivascular adipose tissue reveals critical changes in cell composition, communication, and gene regulatory networks induced by a high fat hypertensive diet. (2025-02-14)
• Mechanotransduction in the Perivascular Adipose Tissue. Arteriosclerosis, Thrombosis, and Vascular Biology (2025-02-13)
• 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) elicited dose-dependent shifts in the murine urinary metabolome associated with hepatic AHR-mediated differential gene expression. (2024-10-25)
• Early life adversity promotes gastrointestinal dysfunction through a sex-dependent phenotypic switch in enteric glia. (2024-06-03)
• A cell atlas of thoracic aortic perivascular adipose tissue: a focus on mechanotransducers. American Journal of Physiology-Heart and Circulatory Physiology (2024-05-01)
• Adipocyte stem and progenitor cell subpopulation proportions. (2024-03-18)
• Expression of transient protein channels in taPVAT and BAT. (2024-03-18)
• Gene ontology term definitions and membership. (2024-03-18)
• Piezo1 RNAscope analysis of taPVAT from female Dahl SS rats. (2024-03-18)
• Re-integration and clustering of adipocytes. (2024-03-18)
• Re-integration and clustering of immune cells. (2024-03-18)
• Table of key resources. (2024-03-18)
• UMAP clustering and cell annotation of Leiden clusters. (2024-03-18)
• How single-cell transcriptomics provides insight on hepatic responses to TCDD. Current Opinion in Toxicology (2023)
• A Cell Atlas of Thoracic Aortic Perivascular Adipose Tissue: a focus on mechanotransducers. (2023-10-09)
• Cystine/Glutamate Xc– Antiporter Induction Compensates for Transsulfuration Pathway Repression by 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) to Ensure Cysteine for Hepatic Glutathione Biosynthesis. Chemical Research in Toxicology (2023-06-19)
• A Case for Accelerating Standards to Achieve the FAIR Principles of Environmental Health Research Experimental Data. Environmental Health Perspectives (2023)
• Analysis of Cell–Cell Communication by Single-Nuclei RNA Sequencing Identifies AHR-Mediated Induction of NRG-ERBB Signaling. Receptors (2023-05-11)
• Single-cell transcriptomics shows dose-dependent disruption of hepatic zonation by TCDD in mice. Toxicological Sciences (2023-01-31)
• Generative Modeling of Single Cell Gene Expression for Dose-Dependent Chemical Perturbations. (2022-10-07)
• Dose-dependent disruption of hepatic zonation by 2,3,7,8-tetrachlorodibenzo-p-dioxin in mice: integration of single-nuclei RNA sequencing and spatial transcriptomics. (2022-06-17)
• Benchmarking of a Bayesian single cell RNAseq differential gene expression test for dose–response study designs. Nucleic Acids Research (2022-05-06)
• Genome-Wide ChIPseq Analysis of AhR, COUP-TF, and HNF4 Enrichment in TCDD-Treated Mouse Liver. International Journal of Molecular Sciences (2022-01-29)
• Benchmarking of a Bayesian single cell RNAseq differential gene expression test for dose-response study designs. (2021-09-10)
• Single-Nuclei RNA Sequencing Assessment of the Hepatic Effects of 2,3,7,8-Tetrachlorodibenzo-p-dioxin. Cellular and Molecular Gastroenterology and Hepatology (2021)
• Genetics-Based Approach to Identify Novel Genes Regulated by the Aryl Hydrocarbon Receptor in Mouse Liver. Toxicological Sciences (2021-05-27)
• 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) alters hepatic polyunsaturated fatty acid metabolism and eicosanoid biosynthesis in female Sprague-Dawley rats. Toxicology and Applied Pharmacology (2020)
• Application of single nuclei RNA sequencing to assess the hepatic effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin. (2020-04-08)
• A toxicogenomic approach for the risk assessment of the food contaminant acetamide. Toxicology and Applied Pharmacology (2020)
• 2,3,7,8-Tetrachlorodibenzo-p-dioxin dose-dependently increases bone mass and decreases marrow adiposity in juvenile mice. Toxicology and Applied Pharmacology (2018)
• Loss of liver-specific and sexually dimorphic gene expression by aryl hydrocarbon receptor activation in C57BL/6 mice. PLOS ONE (2017-09-18)
• Lipidomic Evaluation of Aryl Hydrocarbon Receptor-Mediated Hepatic Steatosis in Male and Female Mice Elicited by 2,3,7,8-Tetrachlorodibenzo-p-dioxin. Chemical Research in Toxicology (2017-04-17)

Employment

• Assistant Professor, Michigan State University (2023-11-01)
• Assistant Professor, Michigan State University (2021-01-01—2023-10-31)