Neera Tewari-Singh, PhD
she/her/hers
Associate Professor
Pharmacology & Toxicology
Associate Professor
Pharmacology & Toxicology
Lab Staff
Colleges
Programs
Sections
- PHM 816 Integrative Toxicology: Mechanisms, Pathology and Regulation (in-person) - Fall Odd Years
Funding
- Phosgene Oxime Cutaneous Toxicity and Mechanisms to Identify Therapeutic Targets, National Institute of Arthritis and Musculoskeletal and Skin Diseases (2017-09-21—2020-08-31)
- Targeted Therapeutic Approaches to Counteract Toxicity from Phosgene Oxime Skin Exposure, National Institute of Arthritis and Musculoskeletal and Skin Diseases (2019-09-10—2022-08-31)
- Treatment strategies for ocular toxicity from chloropicrin, National Eye Institute (2021-09-01—2024-08-31)
- Understanding Mustard Vesicants Distribution and Toxicity in the Eye Using In Vivo and In Silico Models, National Eye Institute (2023-09-01—2026-08-31)
Works
- Dermal Exposure to Vesicating Nettle Agent Phosgene Oxime: Clinically Relevant Biomarkers and Skin Injury Progression in Murine Models. The Journal of pharmacology and experimental therapeutics (2024)
- Dexamethasone targets actin cytoskeleton signaling and inflammatory mediators to reverse sulfur mustard-induced toxicity in rabbit corneas. Toxicology and applied pharmacology (2024)
- Establishing a Dexamethasone Treatment Regimen To Alleviate Sulfur Mustard-Induced Corneal Injuries in a Rabbit Model. The Journal of pharmacology and experimental therapeutics (2024)
- Nitrogen Mustard-Induced Ex Vivo Human Cornea Injury Model and Therapeutic Intervention by Dexamethasone. The Journal of pharmacology and experimental therapeutics (2024)
- Metabolomics for identifying pathways involved in vesicating agent lewisite-induced corneal injury. Experimental eye research (2023)
- Ocular injury progression and cornea histopathology from chloropicrin vapor exposure: Relevant clinical biomarkers in mice. Experimental Eye Research (2023)
- A review of chemical warfare agents linked to respiratory and neurological effects experienced in Gulf War Illness. Inhalation toxicology (2022)
- Effect of dexamethasone treatment at variable therapeutic windows in reversing nitrogen mustard-induced corneal injuries in rabbit ocular in vivo model. Toxicology and applied pharmacology (2022)
- Mast Cells Promote Nitrogen Mustard-Mediated Toxicity in the Lung Associated With Proinflammatory Cytokine and Bioactive Lipid Mediator Production. Toxicological sciences : an official journal of the Society of Toxicology (2021)
- Pathophysiology and inflammatory biomarkers of sulfur mustard-induced corneal injury in rabbits. PloS one (2021)
- Effect of supersaturated oxygen emulsion treatment on chloropicrin-induced chemical injury in ex vivo rabbit cornea. Toxicology letters (2021)
- Special issue: emerging chemical terrorism threats. Toxicology mechanisms and methods (2021)
- Phosgene oxime: a highly toxic urticant and emerging chemical threat. Toxicology mechanisms and methods (2020)
- Toxic consequences and oxidative protein carbonylation from chloropicrin exposure in human corneal epithelial cells. Toxicology Letters (2020)
- A Supersaturated Oxygen Emulsion for the Topical Treatment of Ocular Trauma. Military medicine (2020)
- Acute corneal injury in rabbits following nitrogen mustard ocular exposure. Experimental and molecular pathology (2019)
- Histopathological and Molecular Changes in the Rabbit Cornea From Arsenical Vesicant Lewisite Exposure. Toxicological sciences : an official journal of the Society of Toxicology (2017)
- Efficacy of anti-inflammatory, antibiotic and pleiotropic agents in reversing nitrogen mustard-induced injury in ex vivo cultured rabbit cornea. Toxicology letters (2017)
- Phosgene oxime: Injury and associated mechanisms compared to vesicating agents sulfur mustard and lewisite. Toxicology letters (2017)
- Cutaneous exposure to vesicant phosgene oxime: Acute effects on the skin and systemic toxicity. Toxicology and applied pharmacology (2017)
- Corneal toxicity induced by vesicating agents and effective treatment options. Annals of the New York Academy of Sciences (2016)
- Mustard vesicating agent-induced toxicity in the skin tissue and silibinin as a potential countermeasure. Annals of the New York Academy of Sciences (2016)
- Clinical progression of ocular injury following arsenical vesicant lewisite exposure. Cutaneous and ocular toxicology (2016)
- Nitrogen Mustard-Induced Corneal Injury Involves DNA Damage and Pathways Related to Inflammation, Epithelial-Stromal Separation, and Neovascularization. Cornea (2016)
- Nitrogen mustard exposure of murine skin induces DNA damage, oxidative stress and activation of MAPK/Akt-AP1 pathway leading to induction of inflammatory and proteolytic mediators. Toxicology letters (2015)
- Flavanone silibinin treatment attenuates nitrogen mustard-induced toxic effects in mouse skin. Toxicology and applied pharmacology (2015)
- Topical nitrogen mustard exposure causes systemic toxic effects in mice. Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie (2014)
- Catalytic antioxidant AEOL 10150 treatment ameliorates sulfur mustard analog 2-chloroethyl ethyl sulfide-associated cutaneous toxic effects. Free radical biology & medicine (2014)
- Activation of DNA damage repair pathways in response to nitrogen mustard-induced DNA damage and toxicity in skin keratinocytes. Mutation research (2014)
- Myeloperoxidase deficiency attenuates nitrogen mustard-induced skin injuries. Toxicology (2014)
- Cutaneous injury-related structural changes and their progression following topical nitrogen mustard exposure in hairless and haired mice. PloS one (2014)
- Histopathological and immunohistochemical evaluation of nitrogen mustard-induced cutaneous effects in SKH-1 hairless and C57BL/6 mice. Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie (2013)
- Absence of a p53 allele delays nitrogen mustard-induced early apoptosis and inflammation of murine skin. Toxicology (2013)
- Clinically-relevant cutaneous lesions by nitrogen mustard: useful biomarkers of vesicants skin injury in SKH-1 hairless and C57BL/6 mice. PloS one (2013)
- Silibinin attenuates sulfur mustard analog-induced skin injury by targeting multiple pathways connecting oxidative stress and inflammation. PloS one (2012)
- Silibinin, dexamethasone, and doxycycline as potential therapeutic agents for treating vesicant-inflicted ocular injuries. Toxicology and applied pharmacology (2012)
- Mechanisms of sulfur mustard analog 2-chloroethyl ethyl sulfide-induced DNA damage in skin epidermal cells and fibroblasts. Free radical biology & medicine (2011)
- Sulfur mustard analog, 2-chloroethyl ethyl sulfide-induced skin injury involves DNA damage and induction of inflammatory mediators, in part via oxidative stress, in SKH-1 hairless mouse skin. Toxicology letters (2011)
- 2-Chloroethyl ethyl sulfide causes microvesication and inflammation-related histopathological changes in male hairless mouse skin. Toxicology (2011)
- Efficacy of glutathione in ameliorating sulfur mustard analog-induced toxicity in cultured skin epidermal cells and in SKH-1 mouse skin in vivo. The Journal of pharmacology and experimental therapeutics (2010)
- Biological and molecular mechanisms of sulfur mustard analogue-induced toxicity in JB6 and HaCaT cells: possible role of ataxia telangiectasia-mutated/ataxia telangiectasia-Rad3-related cell cycle checkpoint pathway. Chemical research in toxicology (2010)
- Sulfur mustard analog induces oxidative stress and activates signaling cascades in the skin of SKH-1 hairless mice. Free radical biology & medicine (2009)
- Engineering key components in a synthetic eukaryotic signal transduction pathway. Molecular systems biology (2009)
- Inflammatory biomarkers of sulfur mustard analog 2-chloroethyl ethyl sulfide-induced skin injury in SKH-1 hairless mice. Toxicological sciences : an official journal of the Society of Toxicology (2008)
- Tumor necrosis factor-alpha induces endothelial dysfunction in Lepr(db) mice. Circulation (2007)
- A synthetic de-greening gene circuit provides a reporting system that is remotely detectable and has a re-set capacity. Plant biotechnology journal (2006)
- Use of a herbicide or lysine plus threonine for non-antibiotic selection of transgenic chickpea. Plant cell reports (2004)
Employment
- Associate Professor, Michigan State University (2023-07-01)
- Assistant Professor, Michigan State University (2019-01-01—2023-06-30)
- Assistant Research Professor, University of Colorado Denver (2014-01-01—2018-12-31)