Drug Discovery

Receptors are the macromolecules on which signaling molecules (such as hormones, neurotransmitters and inflammatory mediators) act. Receptors also represent the largest single family of drug targets – so understanding receptors and how they work is a major focus of pharmacology and toxicology.

We are identifying specific receptors and signaling mechanisms involved in disease processes such as hypertension and heart disease, inflammation and fibrosis, cancer, epilepsy, stroke and neurodegenerative diseases. Employing a rigorous "design-test-learn" approach, we design and optimize promising drug candidates for pre-clinical testing to discover novel therapeutic agents for important unmet medical needs.